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41.
42.
胰岛素泵治疗与2型糖尿病第一时相分泌的研究进展 总被引:5,自引:0,他引:5
随着对糖尿病机理研究的深入,发现胰岛β细胞第一时相分泌,对糖尿病的发生、发展有重要影响,新诊断2型糖尿病患者早期予胰岛素泵治疗,模拟生理性胰岛素分泌方式,可改善第一时相分泌,促进胰岛β细胞功能的修复,利于糖尿病的治疗及预后。 相似文献
43.
主动脉内球囊反搏(intraaortic balloon pump,IABP)已广泛应用于成年人心源性休克和围手术期低心排血量综合征的治疗,并取得良好的治疗效果,但在小儿中的应用仍较局限。现就有关IABP在小儿中的应用进行综述,着重分析IABP的适应证和影响在小儿中应用的技术困难和其他因素,介绍小儿IABP应用的技术要点,可能的并发症和治疗效果。在无体外膜式氧合器(ECMO)和左心辅助设备的情况下,小儿心脏直视手术后如不能脱离体外循环机或发生严重低心排血量综合征等,应用IABP治疗可收到较好的效果。 相似文献
44.
Hikaru Matsuda Yoshiyuki Taenaka Nobukazu Ohkubo Masakatu Ohtani Kyouichi Nishigaki Shigeaki Ohtake Takuya Miura Nobuyuki Taenaka† Hisateru Takano Hajime Hirose Yasunaru Kawashima 《Artificial organs》1988,12(5):423-430
Pneumatic ventricular assist device (VAD) was utilized for cardiogenic shock after intracardiac operation in two children with complex cardiac anomalies based with single ventricle. In the first case (a 10-year-old), after a modified Fontan operation, VAD was placed between the functional left atrium and ascending aorta, serving as a "artificial single ventricle" with neither pumping chamber nor artificial support in the right side of the heart. The systemic circulation was maintained by keeping relatively high central venous pressure. In another child (a 3-year-old) who underwent repair of incompetent atrioventricular valve leaving intracardiac lesions, VAD was placed between the common atrium and ascending aorta, serving as a pump for both pulmonary and systemic circulation with regulation of pulmonary blood flow through an aortopulmonary Gore-Tex shunt. The circulatory assist with VAD was utilized for 5 and 6 days, respectively. Although weaning from the device was not feasible in both patients because of the pulmonary dysfunction, these experience showed the possible use of VAD for cardiogenic shock after surgery in patients with complex cardiac anomalies. 相似文献
45.
The effects of vasopressin on membrane potential and tension were studied in isolated segments of basilar arteries from the
University of Iowa colonies of normotensive inbred Kyoto-Wistar rats (WKY) and stroke-prone spontaneously hypertensive rats
(SP-SHR). In the presence of vasopressin (0.01–0.3 IU/ml), basilar arteries from WKY, but not from SP-SHR, developed rhythmic
contractions. These contractions were recorded in 13 of 14 WKY basilar arteries, were unaffected by pretreatment with 6-hydroxydopamine,
and were characterized by 20–100 dyne oscillations in tension, occurring 1–3 cycles/min, and superimposed on the vasopressin-induced
contraction (averaging 60 dynes at 0.01 IU/ml or 160 dynes at 0.3 IU/ml). However, resting membrane potentials were not different
in SP-SHR vs. WKY at 37°C, and both strains showed about the same (11 mV) depolarization by 0.1 IU/ml of vasopressin. The
rhythmic contractions were enhanced by K+-free solution, and abolished in the presence of high K+ solution (30 mM), suggesting that active Na+−K+ transport may be involved in modulating the rhythmic activity. These findings are consistent with the hypothesis that the
vasopressin-induced rhythmic contractions in WKY basilar arteries are at least partly dependent on a reduced activity of electrogenic
Na+−K+ active transport in WKY as compared to SP-SHR.
This research was supported by Grant Nos. HL14388 and HL16328 from the National Institutes of Health. Dr. Rusch is the recipient
of Postdoctoral Fellowship HL06907. 相似文献
46.
目的分析应用Orthofix-微型器治疗第一掌骨基底部Bennett骨折的临床疗效。方法收集2009年1月~2013年1月我院31例采用Orthofix-微型器治疗的第一掌骨基底部Bennett骨折患者。记录患者年龄、性别等基线资料,以及术后上肢臂、肩、手功能调查量表(Disabilities of the arm,shoulder and hand,DASH)评分,随访终末期采用指总关节活动度(Total action movement,TAM)评分。结果随访6~24个月,平均14.4月,手术时间为18~40分钟,平均29.1分钟,术中出血量10~30m L,平均14.5m L。术后3月、术后6月及终末期DASH评分之间比较,差异均有统计学意义(0.05)。随访终末期,其中26例解剖复位,5例骨折对线良好,TAM评分优22例,良7例,差2例。随访期间未发生桡神经浅支损伤、钉道感染等并发症。结论 Orthofix-微型外固定器治疗Bennett骨折操作简单、疗效满意。 相似文献
47.
J. L. Borke A. Caride A. K. Verma J. T. Penniston R. Kumar 《Pflügers Archiv : European journal of physiology》1990,417(1):120-122
We used a monoclonal antibody (5F10) specific for the human erythrocyte plasma membrane Ca++-pump to demonstrate the presence and distribution of Ca++-pump epitopes in rat intestine. In paraffin embedded tissue sections, antibody 5F10 binds to epitopes in the basolateral membranes of absorptive cells in rat duodenum and portions of jejunum but not ileum. Western blot analysis of intestinal mucosal proteins with antibody 5F10 shows binding of antibody to major bands of Mr 135,000 and Mr 72,000, and to lesser bands of Mr 125,000 and Mr 27,000. This pattern was seen in mucosal homogenates of rat duodenal and jejunal cells and to a lesser extent in ileal cells. The Mr 135,000 band corresponds to the molecular weight of Ca++-pumps in other tissues. The other bands correspond in size to known proteolytic fragments of the Ca++-pump. Slot-blot analysis of nitrocellulose immobilized mucosal homogenates shows binding of 5F10 to be greatest in duodenum and least in ileum. Ca++- transport studies by the everted gut sac technique show a correlation between vitamin D induction of active Ca++-transport and the segmental distribution of Ca++-pump epitopes. 相似文献
48.
Stéphane Genet Raymond T. Kado 《Pflügers Archiv : European journal of physiology》1997,434(5):559-567
The contribution of the Na/K ATPase (pump) current to the polarization of the Purkinje cell has been studied using slices
of the rat cerebellum by blocking the pump with dihydro-ouabain (DHO) while recording the membrane potential with microelectrodes
in the somata. From our recordings, it appeared that blocking the pump depolarized the Purkinje cells more rapidly than might
be expected from shifts in Na+ and K+ concentrations, suggesting the removal of a hyperpolarizing current. Application of DHO, in the presence of tetrodotoxin (TTX),
led to calcium spike firing and plateau-like discharges suggesting activation of voltage-dependent calcium channels in the
dendrites. Adding 2 mM Co2+ to the medium did not prevent the depolarizations. Removing calcium from the bathing medium containing 2 mM Co2+ blocked the spiking activity but DHO application still produced a depolarization. Experiments to measure the current inhibited
by DHO indicated that the Na/K pump supplies a constant current of 240 pA. Substitution of the sodium with choline produced
a hyperpolarization, during which DHO had no effect on the membrane potential. Substitution of the sodium with lithium produced
only a slowly developing depolarization. It is concluded that in the cerebellar Purkinje cell, a continuous sodium ion influx
activates the pumps which produce a current that directly contributes to the membrane polarization. Possible pathways for
this sodium influx are discussed.
Received: 3 April 1997 / Received after revision and accepted: 12 May 1997 相似文献
49.
Influence of vascular parameters on the effectiveness of intra-aortic balloon pumping: A model study
The intra-aortic balloon pump has been widely used as a temporary heart-assist device. In this investigation, a nonlinear
mathematical model of the arterial system and intra-aortic balloon pump was studied analytically. Thus, the influences of
a number of vascular parameters on the effectiveness of intra-aortic balloon pumping (IABP) were determined. The effects of
changes in vascular parameters of the model on a number of performance indexes were investigated. These performance indexes
(aortic mean diastolic pressure, aortic end diastolic pressure, cardiac output, coronary flow and phase differences between
the fundamental Fourier components of aortic root pressure and flow) were used as the criterion for an evaluation of the effectiveness
of the assist pump. The following vascular parameters were perturbed by four steps (±10%, ±20%) from the values in the standard
model: heart rate, peripheral resistance, left ventricular pressure, aortic elastance, aortic radius, arterial wall thickness,
and aortic length. This model was evaluated for a wide range of balloon-pump phase-control settings (assisted case) and for
the unassisted case (when the pump is disabled). It is concluded that changes in heart rate, peripheral resistance and left
ventricular pressure cause the most significant changes in pump performance.
Dr. Ohley is with the Datascope Corporation
Dr. Kao is with the Technicare Corporation 相似文献
50.
Simeon P. Cairns John A. Flatman Torben Clausen 《Pflügers Archiv : European journal of physiology》1995,430(6):909-915
An increased extracellular K+ concentration ([K+]0) is thought to cause muscle fatigue. We studied the effects of increasing [K+]0 from 4 mM to 8–14 mM on tetanic contractions in isolated bundles of fibres and whole soleus muscles from the rat. Whereas there was little depression of force at a [K+]0 of 8–9 mM, a further small increase in [K+]0 to 11–14 mM resulted in a large reduction of force. Tetanus depression at 11 mM [K+]o was increased when using weaker stimulation pulses and decreased with stronger pulses. Whereas the tetanic force/resting membrane potential (E
M) relation showed only moderate force depression with depolarization from –74 to –62 mV, a large reduction of force occurred whenE
M fell to –53 mV. The implications of these relations to fatigue are discussed. Partial inhibition of the Na+-K+ pump with ouabain (10–6 M) caused additional force loss at 11 mM [K+]0. Salbutamol, insulin, or calcitonin gene-related peptide all stimulated the Na+-K+ pump in muscles exposed to 11 mM [K+
0] and induced an average 26–33% recovery of tetanic force. When using stimulation pulses of 0.1 ms, instead of the standard 1.0-ms pulses, force recovery with these agents was 41–44% which was significantly greater (P < 0.025). Only salbutamol caused any recovery ofE
M (1.3 mV). The observations suggest that the increased Na+ concentration difference across the sarcolemma, following Na+-K+ pump stimulation, has an important role in restoring excitability and force. 相似文献