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91.
目的:观察丙氨瑞林对子宫内膜癌的治疗作用。方法:对诊刮确诊的17例子宫内膜癌病人,予丙氨瑞林700μg,im,qd×7d,用药前后作性激素测定及组织学检查。结果:绝经妇女用药后血中FSH和LH下降(P<0.01和<0.05),雌二醇、孕酮及睾丸酮变化不明显。其中13例内膜样腺癌用药后有丝分裂指数明显下降(P<0.01),有丝分裂指数变化与癌周内膜之反应有关。呈增生反应癌周内膜癌组织有丝分裂指数下降值明显高于呈萎缩状态癌周内膜。结论:丙氨瑞林治疗子宫内膜癌后能降低FSH和LH水平,对子宫内膜癌尤其是雌激素依赖性内膜癌有一定疗效。 相似文献
92.
3例前列腺癌施行双侧睾丸节除术后2-12周的患,每天肌注苯甲酸雌二醇1mg,d。治疗前后分别每10min采血一次,作7h LH脉冲分析。结果表明,3例患平均血清LH水平分别由177.58±3.20,138.30±5.83和145.88±3.82IU/LGHBTGC 174.90±7.60,132.02±5.77和142.80±3.65IU/L(P均<0.01),但LH脉冲幅度和频率无明显变化( 相似文献
93.
选择某电子对抗团战士和某坦克旅战士共64人,分别在高温、高湿等因素作用下连续作业1h(摩托小时),观察战士体内激素及电解质的变化情况。结果表明:两部队战士的心钠素、皮质醇、醛固酮水平作业前后有非常显著性以上的差异;血清K~+、Ca~(2+)浓度降低,Na~+浓度升高。以上结果表明:高温环境对战士体内激素水平影响显著,机体出现应激性改变。 相似文献
94.
David Crews 《Psychoneuroendocrinology》1998,23(8):751-764
Behaviors are adaptations to the physical, biotic, and social environments. Great diversity exists among vertebrates in reproductive behaviors and the neuroendocrine mechanisms underlying these behaviors. Study of this diversity illuminates species, population, and sex differences in hormone–brain-behavior relations. It also can provide insights into how and why certain neuroendocrine mechanisms evolved. Discoveries in evolution and ecology, neuroscience and endocrinology, are complementary and interrelated, and when applied in behavioral neuroscience, the investigator's perspective is less constrained by existing dogma. Naturally-occurring organisms not typically studied can be especially useful as their unusual adaptations illustrate alternative solutions to particular problems. Indeed, they ‘often force one to abandon standard methods and standard points of view’ with the result that, ‘in trying to comprehend their special and often unusual adaptation, one often serendipitously stumbles on new insights’ (Bartholomew, 1982). Thus, to ignore comparative research would greatly limit our understanding of the evolution of hormone-behavior relations. As Bullock (1984) admonishes, “without due consideration of the neural and behavioral correlates of differences between higher taxa and between closely related families, species, sexes, and stages, we cannot expect to understand our nervous systems or ourselves”. © 1998 Elsevier Science Ltd. All rights reserved. 相似文献
95.
观察30例正常对照组14例冠心病心衰患者,20例冠心病心功能代偿期患者血清T3,T4,rT3,FT3,FT4,TSH的变化,结果:两组患者与对照组比较,均有T3下降rT3升高,尤以冠心病心衰患者表现更明显,同时伴T4及FT3下降,有显著性差异,3组之间FT4比较无差异。结果提示:测定冠心病患者血清甲状腺激素水平,有助于了解病情的严重程度及判断其预后。 相似文献
96.
Papapoulos S. E.; Berg H. v.d.; Frolich M.; Valentijn R. M. 《Nephrology, dialysis, transplantation》1988,3(5):647-650
The formation of 1.25-dihydroxycholecalciferol (1.25-(OH)2D3after single intravenous injections of 1-hydroxycholecalciferol(1-OHD3) was examined in four patients with chronic renal failureon regular haemodialysis. Following 13µg 1-OHD3administered at weekly intervals, 1.25-(OH)2D3 appeared in thecirculation within 1 h, and peak concentrations were reachedbetween 2 h and 5 h. By 8 h serum 1.25-(OH)2D3 concentrationshad started declining and by 44 h they had returned to baselineafter 1µg 1-OHD3 but they were still above basal after2 and 3 µg by an average of 30 pmol/l. One week afterinjections, concentrations were back to basal in all patientsstudied. The serum 1,25-(OH)2D3 dose response to injected la-OHDwas linear, indicating ample capacity of the liver 25-hydroxylaseto further hydroxylate 1-OHD. However, examination of the individualresponses revealed lower increments in serum 1.25-(OH)3 concentrationsin the patients with the highest basal serum 25-hydroxyvitaminD concen trations. Intravenous 1-OHD3 may be useful in the furtherstudy of the interactions between 1.25-(OH)23 calcium and PTHin chronic renal failure, as well as of the hepatic metabolismof vitamin D. 相似文献
97.
目的 探讨不同生长激素分泌状态下矮身材儿童血脂水平的差异,为生长激素缺乏对儿童体脂代谢的影响提供理论依据。方法 收集矮身材儿童188例,依据生长激素药物激发试验峰值分为生长激素完全缺乏(cGHD)组、生长激素部分缺乏(pGHD)组、非生长激素缺乏性(nGHD)组,研究对象均禁食禁水10 h后空腹测定总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL)和高密度脂蛋白胆固醇(HDL)4项血脂水平。结果 3组儿童HDL水平比较差异无统计学意义(P>0.05);3组儿童TC、TG、LDL、non-HDL水平比较差异均有统计学意义(P<0.05);组间两两比较,cGHD组TC、LDL、non-HDL水平较其他组明显升高(P<0.05),cGHD组TG水平较nGHD明显升高(P<0.05),与pGHD组比较差异无统计学意义(P>0.05)。pGHD、nGHD组高TC、高LDL及高non-HDL的发生率明显低于cGHD组(P<0.05),nGHD组临界高LDL的发生率明显低于cGHD组(P<0.05)。而3组间TG、HDL的异常发生率及TC、TG... 相似文献
98.
Dominique Chesnoy-Marchais Janine Fritsch 《Pflügers Archiv : European journal of physiology》1990,415(1):104-114
In primary cultures of rat osteoblasts, studied with the whole-cell configuration of the patch-clamp technique, 8-bromo-cyclic AMP (8BrcAMP) forskolin (FS) and 1–34 parathyroid hormone (PTH) were shown to activate a Cl conductance. This conductance shows a pronounced outward rectification, even with symmetrical Cl concentrations. It is blocked partially and reversibly by 4,4-diisothiocyanatostilbene 2,2-disulfonic acid (DIDS) or diphenylcarboxylate (DPC). The blockade induced by DIDS is time-and voltage-dependent. The Cl responses to FS and PTH develop slowly, after a delay of several seconds and are very slowly reversible. These responses were observed only in a fraction of the cells tested and their detection was favoured by cell dialysis. This Cl current should be taken into account for studying possible modulations of the voltage-gated Ca currents of osteoblasts. It is suggested that its physiological role may be related to the well-known morphological changes induced by PTH in osteoblasts. The cyclic AMP-sensitivity, the outward rectification and the sensitivity to dialysis of this Cl current are reminiscent of the properties of the cystic fibrosis-sensitive Cl channels of epithelial cells. 相似文献
99.
100.
Crosignani Pier Giorgio; De Cecco Luigi; Gastaldi Attilio; Venturini Pier Luigi; Oldani Sabina; Vegetti Walter; Semino Antonio; Commare Paolo La; Vercellini Paolo 《Human reproduction (Oxford, England)》1996,11(12):2732-2735
An open-label randomized pilot study was conducted to evaluatethe efficacy and acceptability of 6 months treatment with leuprolidein a 3-monthly versus a monthly i.m. depot injection for therelief of chronic pelvic pain in women with endometriosis. Atotal of 30 women aged 18-38 years were allocated to the 3-monthlydepot arm (n = 15) or to the monthly depot arm (n = 15) afterlaparoscopic diagnosis of pelvic endometriosis. Mean (SD) deepdys-pareunia scores according to a 03 point verbal ratingscale decreased from 1.8 (0.9) at baseline to 1.3 (0.7) at theend of treatment in the 3-monthly depot group and from 2.1 (1.2)to 13 (0.7) in the monthly depot group. Correspondingvalues in non-menstrual pain scores fell from 2.1 (0.6) to 1.1(03), and from 2.1 (0.8) to 1.2 (0.4) respectively, withoutstatistically significant differences between the groups. Serumluteinizing hormone (LH) and 17-oestradiol concentrations weresignificantly suppressed at 12 and 24 weeks compared with baselinevalues, without differences between the groups. The monthlydepot caused a slightly more marked inhibition of serum folliclestimulating hormone (FSH) levels with respect to the 3-monthlypreparation. Mean (SD) endometriosis scores at baseline andat 6-month follow-up laparoscopy were respectively 32.8 (25.1)and 12.2 (9.3) in the 3-monthly depot group and 29.0 (22.7)and 13.1 (15.3) in the monthly depot group (paired Mest, P 0.05). Mean percentage decrease in lumbar spine bone mineraldensity was 5.2% in the former and 4.9% in the latter subjects.In the 3-monthly depot group, 13 women graded the tolerabilityof their treatment schedule as good compared withseven in the monthly depot group (2 = 5.40, P = 0.02). 相似文献