HucMSC-Derived Exosomes Mitigate the Age-Related Retardation of Fertility in Female Mice

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Biological and radiological exploration and management of non-functioning pituitary adenoma

Non-functioning pituitary adenoma may be totally asymptomatic and discovered “incidentally” during radiological examination for some other indication, or else induce tumoral signs with compression of the optic chiasm and pituitary dysfunction. Non-functioning adenomas are mainly gonadotroph, but may also be “silent”. Treatment strategy depends on initial clinical, biological, ophthalmological and radiological findings. The present French Society of Endocrinology Consensus work-group sought to update the pitfalls associated with hormone assay and outline a hormonal exploration strategy for diagnosis and follow-up, without overlooking the particularities of silent adenoma. We also drew up basic rules for initial exploration and radiological follow-up of both operated and non-operated pituitary adenomas.     

Use of volume-targeted non-invasive bilevel positive airway pressure ventilation in a patient with amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which most patients die of respiratory failure. Although volume-targeted non-invasive bilevel positive airway pressure (BPAP) ventilation has been studied in patients with chronic respiratory failure of various etiologies, its use in ALS has not been reported. We present the case of a 66-year-old woman with ALS and respiratory failure treated with volume-targeted BPAP ventilation for 15 weeks. Weekly data downloads showed that disease progression was associated with increased respiratory muscle weakness, decreased spontaneous breathing, and increased use of non-invasive positive pressure ventilation, whereas tidal volume and minute ventilation remained relatively constant.     

The retrospective study for effectiveness of cervical cerclage in preventing recurrent preterm birth

ObjectiveThis study aimed to clarify the effectiveness of cervical cerclage in preventing recurrent preterm births.Materials and methodsA retrospective study was conducted using the perinatal registration database of the Japan Society of Obstetrics and Gynecology for the Perinatal Center from 2014 to 2016. The efficacies of history-indicated, ultrasound-indicated, and physical examination-indicated cerclage as preventive treatments for women with a history of preterm birth were evaluated by comparing cerclage and non-cerclage cases. Fisher's exact test was performed to evaluate any significant differences in patient backgrounds. Prior to the evaluation, propensity score matching was performed for history-indicated and ultrasound-indicated cerclage patients.ResultsFor this study, 6060 multiparous women with a history of preterm birth were reviewed. After excluding 17 patients with unknown indications for cervical cerclage, 6043 patients were included in the study. History-indicated and ultrasound-indicated cerclage did not reduce the risk of preterm birth in subsequent pregnancies for any of the pregnancy periods (p = 0.413, p = 1.000). In contrast, physical examination-indicated cerclage significantly reduced the risk of subsequent preterm births for all pregnancy periods (p < 0.001).ConclusionSubsequent preterm births were effectively prevented only in physical examination-indicated cerclage cases. For history- or ultrasound-indicated cerclage, statistically significant differences in subsequent preterm births were not evident.     

慢性阻塞性肺疾病合并呼吸衰竭临床治疗效果分析

目的 探究慢性阻塞性肺疾病（COPD）合并呼吸衰竭临床治疗效果分析.方法 选择我院2011年2月-2012年2月收治的120例COPD合并呼吸衰竭患者,随机分为对照组和观察组,各60例.对照组给予常规治疗,观察组在此基础上联合无创正压机械通气治疗,治疗1d,观察两组患者各临床检验结果、临床疗效及不良反应.结果 两组患者治疗1d后氧分压（PaO2）、二氧化碳分压（PaCO2）、pH、心率（HR）、呼吸（R）等临床检验结果均较治疗前好转,但观察组的治疗效果优于对照组,差异有统计学意义（P＜0.05）.观察组的总有效率（91.7%）高于对照组（76.7%）,差异有统计学意义（P＜0.05）.两组均未发生不良反应.结论 对慢性阻塞性肺疾病合并呼吸衰竭患者应用无创通气法治疗效果显著,且不良反应少,值得临床应用.