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31.
Magnetization prepared segmented acquisition requires a view order that maximizes signal contrast during the acquisition of the central portion of k-space. Steady state free precession (SSFP) acquisition further requires a view order that minimizes changes in phase-encoding gradients from one repetition to the next in order to minimize eddy current artifacts. In this article, optimal view ordering schemes satisfying these two requirements are formulated and applied to inversion prepared 3D SSFP contrast-enhanced MR angiography (MRA). Experiments on phantoms and pigs demonstrated improved background suppression and reduced image artifacts. 相似文献
32.
汉防己甲素抑制三种神经递质引起的新生大鼠脑细胞内游离钙的升高 总被引:1,自引:0,他引:1
《中国药理学通报》1995,(3)
应用Pura-2技术测定游离新生大鼠脑[Ca2+]i浓度的技术、研究了Tet对静息脑[Ca2+]i和3种递质引起的脑[Ca2]i变化的影响。Tet(1,10和20μmol·L-1)对静息脑[Ca2+]i无明显影响。Tet(10μmol·L-1)可降低L-Gln(0.1、1.0和10μmol·L-1)引起的脑(Ca2+)i的升高。在Hank's液Ca2+为1.3mmol·L-1时,Tet10μmol·L-1可降低His(50和100μmol·L-1)和5-HT(0.1、1.0、10和100μmol·L-1)引起的脑[Ca2+]i的升高。但不能降低Hank's液无Ca2+时His和5-HT引起的脑[Ca2+]i的升高。研究表明Tet可阻滞L-Gin、His和5-HT受体调控的钙通道。但对His和5-HT引起的细胞内贮存钙的释放并无明显影响。Tet的这种降低脑[Ca2+]i的作用可能是其治疗脑缺血性疾病的机理之一。P<0.01在Tet10μmol·L-1作用下,相同浓度的细胞外液钙和His(0、50和100μmol·L-1),脑[Ca2+]i分别是221±5、245±5和302±6nmol·L-1。增加了11.8? 相似文献
33.
本文报道1000例正常人发自由基的电子自旋共振波谱饱和功率(ESR-SP)的检测结果。所得正常值的全组中位数为2.496mw;95%上下限分别为2.989及1.720mw。如按性别统计,则女性下限(1.617mw)较男性(1.983mw)为低,(P<0.05)。按年龄分别统计,则40岁以上的中位数(2.376mw)及其下限(2.009mw)高于40岁以下的中位数(2.548mw)及其下限(1.597mw),两者差异有显著性(P<0.05)及极显著性(P<0.01)。因此在使用此正常值指标时,必须注意性别与年龄因素。 相似文献
34.
The effects of combined use of earthworm extract(912)and HpD-laser on the produc-tion of reactive oxygen and the biosynthesis of DNA in S_(180) tumor cells were studied throughchemiluminescence measurement and[~3H]-TdR incorporation assay.The results showed that as com-pared with the control,the intensity of chemiluminescence emitted by tumor cells treatedsimultaneously with 912 and HpD-laser was enhanced more than ten-folds,while that treated with912 or HpD-laser alone was increased only 2~4 folds.The[~3H]-TdR incorporation into tumorcells of the former group was inhibited upto 74.1%,and that of the latter groups decreased onlyby 42.2% and 40.0%,respectively.In accordance with these biochemical changes,the ultrastructuraldamage of tumor cells of the former,combinedly treated group appeared to be the most serious.This suggests an additive effect of 912 with HpD-laser on tumor cells.In addition,if free radicalscavengers,such as catalase and superoxide dismutase,were added to the reaction systembefore chemiluminescence assay,the luminescent enhancement effect mentioned above was dramaticallyalleviated,implying the presence of O_2~ and H_2O_2 in the system.Therefore,as to the toxic effecton tumor cells,912 and HpD-laser are not only additive in efficiency,but also similar in theunderlying mechanism of action. 相似文献
35.
Shun'Ichi Abe Hiroshi Yoshimura Hideki Tabara Mitsuo Tachibana Naomi Monden Teruhisa Nakamura Saburou Nagaoka 《Journal of surgical oncology》1995,59(4):226-229
Patients with stage T3N0~2M0 gastric carcinoma (n = 108) were studied for relevant prognostic factors. Peritoneal lavage cytology (PLC) was performed in all. In univariate analysis, 5-year survival rates were better with smaller serosal invasion (diameter <3.0 cm vs. ≥3.0 cm, 61% vs. 37%, P < 0.05) and fewer metastatic nodes (≤5 vs. ≥6, 57% vs. 29%, P < 0.05). In multivariate analyses, only these two factors were significant. The predictive value of PLC was not shown in both univariate and multivariate analyses. Peritoneal recurrence occured in 14 (22%) of 77 patients with negative PLC, and in 3 (18%) of 17 with positive PLC, the difference being not significant. Our results indicate that PLC is insensitive in predicting the development of peritoneal recurrence. Its role in the estimation of survival is limited, as many will die of visceral or locoregional recurrence if not of peritoneal dissemination. 相似文献
36.
A M Abdel Gader A A Al-Mishari S A Awadalla N M Buyuomi T Khashoggi M Al-Hakeem 《International journal of gynaecology and obstetrics》2006,95(3):248-253
OBJECTIVE: To clarify the role played by tissue factor pathway inhibitor (TFPI) in pregnancy hypertension. METHODS: Using enzyme-linked immunosorbent assays, hemostatic measurements were obtained for women with pre-eclampsia (n=51), nonproteinuric hypertension of pregnancy (n=62), postpartum pre-eclampsia 24 h after childbirth (n=31), and no hypertension (healthy pregnant controls, n=100). RESULTS: There was a significant increase in circulating free TFPI levels in women with pre-eclampsia (9.7+/-6.2 ng/mL) or nonproteinuric hypertension of pregnancy (8.3+/-5.3 ng/mL) compared with healthy controls (5.3+/-2.1 ng/mL). In women with pre-eclampsia the levels remained elevated after placental delivery (10.6+/-4.0 ng/mL). Free protein S levels were significantly higher in women with pre-eclampsia (40.0%+/-10.7%), nonproteinuric hypertension of pregnancy (37.1%+/-12.5%), or postpartum pre-eclampsia (39.3%+/-9.1%) than in healthy pregnant controls (32.2%+/-8.5%). CONCLUSION: Increased levels of the physiologically active free forms of TFPI and free protein S, 2 coagulation inhibitors, may protect women with pregnancy-induced hypertension from the risks of hemostatic activation. 相似文献
37.
G. Kostopanagiotou A. Pandazi I. Andreadou A. Doufas I. Chondroudaki T. Kotsis D. Rizos C. Costopanagiotou V. Smyrniotis 《European journal of vascular and endovascular surgery》2005,30(6):648-653
OBJECTIVE: We investigated the dose-related effect of dopexamine and dopamine on free radical production and lipid peroxidation estimated by MDA measurements in an ischaemia-reperfusion model of supraceliac aortic repair. DESIGN: Prospective, randomized, blinded experimental study. MATERIALS: Twenty-five healthy pigs. METHODS: All experiments were performed under general endotracheal anaesthesia. Supraceliac aortic cross clamping was performed in all pigs. The pigs were randomly assigned into five groups (n=5 in each group) and received a continuous intravenous infusion of normal saline (CTL), dopamine 2 microg kg(-1)min(-1) (dopa 2), dopamine 8 microg kg(-1)min(-1) (dopa 8), dopexamine 2 microg kg(-1)min(-1) (dopex 2), dopexamine 8 microg kg(-1)min(-1) (dopex 8). Cardiac output, mean arterial pressure, arterial blood gas analysis and blood sampling for plasma MDA measurements (to reveal lipid peroxidation) were recorded after induction of anaesthesia (baseline), 60 and 120 min after cross-clamping of aorta (ischaemia phase), and 60 and 120 min after restoration of flow (reperfusion phase). RESULTS: Dopexamine and dopamine at 8 microgkg(-1)min(-1) reduced MDA at 60 and 120 min after reperfusion. CONCLUSION: Dopexamine seems superior to dopamine in reducing oxygen free radicals and subsequent lipid peroxidation during reperfusion after supraceliac aortic cross clamping in pigs. 相似文献
38.
Evidence to suggest the presence of abnormal metabolism of oxygen free radicals in progressive muscular dystrophy is presented using an animal model. In the superficial pectoral muscles of dystrophic chickens, enzyme activities regulating the metabolism of oxygen free radicals, i.e., catalase, superoxide dismutases and glutathione peroxidase, were significantly elevated within 1 week of hatching. Activities of related enzymes, i.e., glutathione reductase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase were also elevated. In contrast, the specific activity of phosphofructokinase, the rate-limiting enzyme of the glycolytic pathway, was normal during the first 4-week period. These results suggest that there is an increased turnover of oxygen free radicals in the dystrophic muscle. This concept appears important in a further investigation of the pathogenesis and treatment of progressive muscular dystrophies. 相似文献
39.
应用电子自旋共振波谱仪(ESR)直接检测了缺血-再灌注兔心肌肌浆网自由基的变化,以探讨肌质网系统与氧自由基的关系。实验中将20只兔随机分为再灌注对照组、超氧化物歧化酶(SOD)组、ATP-氯化镁组和人参皂甙Re组。实验结果,g值2.0046处为半醌自由基波谱,其相对浓度各组依次为78.94±2.126,14.46±2.86,20.65±7.65,14.66±3.67(x±SD),对照组与用药组均有显著性差异(P<0.05),表明缺血-再灌注兔心肌肌浆网产生大量的自由基,用ESR可以直接检测到半醌自由基,外源性高能磷酸盐制剂ATP-氯化镁及人参皂甙Re与超氧化物歧化酶一样,发挥清除兔心肌肌浆网自由基的作用。 相似文献
40.
The healthy respiratory system has a remarkable capacity for meeting the metabolic demands placed upon it during strenuous exercise. For example, in order to regulate alveolar partial pressure of oxygen and carbon dioxide during heavy workloads, a 20-fold increase in alveolar ventilation can occur. The high metabolic costs and subsequent increased work of breathing associated with this ventilatory increase can result in a number of limitations to the healthy respiratory system. Two examples of respiratory system limitations that are associated with a high work of breathing are expiratory flow limitation and exercise-induced diaphragmatic fatigue. Expiratory flow limitation can lead to an inability to increase alveolar ventilation () in the face of increasing metabolic demands, resulting in gas exchange impairment and diminished endurance exercise performance. Furthermore, the high ventilatory requirements of endurance athletes and the inherent anatomical differences in females could make these groups more susceptible to expiratory flow limitation. Fatigue of the diaphragm has also been documented after strenuous exercise and may be related to a mechanism which increases sympathetic vasoconstrictor outflow and reduces limb blood flow during prolonged exercise. This competition between the muscles of respiration and locomotion for a limited cardiac output may have dramatic consequences for exercise performance. This brief review summarizes the literature as it pertains to the work of breathing, expiratory flow limitation, and exercise-induced diaphragmatic fatigue in healthy humans. 相似文献