介入技术在终止剖宫产后子宫下段疤痕早期妊娠的应用

目的:探讨剖宫产后子宫下段疤痕早期妊娠的诊断和处理。方法:回顾分析1994年5月~2004年8月本院收治24例剖宫产后子宫下段疤痕妊娠合并胎盘绒毛植入的临床资料。结果:24例中,9例术前未明确诊断,流产术中大出血,并行子宫动脉栓塞,其中1例栓塞后要求切除子宫;15例术前明确诊断,先行子宫动脉栓塞,而后再行流产术,无一例大出血保留了子宫。结论:有剖宫产史的患者,再次妊娠时有发生子宫下段疤痕妊娠的危险,行流产术时可能出现难以控制的大出血,子宫动脉栓塞是首选的行之有效的治疗方法。     

环氧合酶-2在子宫内膜异位症子宫内膜组织中的表达

目的：研究环氧合酶-2（COX-2）在子宫内膜异位症（内异症）在位子宫内膜组织和异位子宫内膜组织中的表达及意义。方法：采用免疫组织化学方法检测30例卵巢内异症在位内膜、10例卵巢巧克力囊肿壁异位内膜及27例正常子宫内膜中COX-2的分布和表达。结果：COX-2在3组子宫内膜腺上皮细胞和间质细胞中均可见表达。COX-2在正常对照组内膜和卵巢内异症组在位内膜腺上皮细胞中的表达均是分泌期高于增生期（P<0.05)，而在间质细胞中的表达分泌期与增生期比较无统计学差异（P>0.05)。COX-2在卵巢内异症组在位和异位内膜中的表达均高于对照组（P<0.05），而内异症患者在位和异位内膜中COX-2的表达则无统计学意义（P>0.05）。结论：COX-2在卵巢内异症在位和异位内膜中表达增高，可能与卵巢内异症的病理异常有关。     

超选择性血管造影并栓塞治疗空回肠出血灶

目的探讨经皮肠系膜上动脉造影并选择性栓塞术治疗空回肠急慢性出血病灶的可行性。方法对6例空回肠急慢性出血患者进行回顾性分析和总结，其中空肠壁血管畸形2例，空肠间质瘤1例，回盲部溃疡并出血3例。均经皮肠系膜上动脉造影明确诊断及出血部位，超选择微导管插入靶血管注入明胶海绵颗粒栓塞止血，再造影复查显示止血成功。除1例空肠间质瘤未能排除恶性肿瘤，10天后行择期剖腹术外，其余5例均未再行手术，随访至今情况良好。结果5例空回肠及回盲部溃疡出血患者经超选择性动脉造影并栓塞治疗，全部即时止血成功，1例空肠间质瘤明确诊断并及时手术，所有患者均痊愈出院。结论空回肠出血部位性质的确定，特别对出血量大而时间较久的患者，内科疗法效果不理想，剖腹探查有较大的盲目性，经皮肠系膜上动脉超选择性动脉造影并栓塞止血，创伤小、并发症少，可同时进行诊断、治疗，具有其独特的优越性，值得推广。     

产科子宫切除术治疗产科出血45例分析

目的: 探讨降低产科子宫切除术及并发症发生的可能性。方法: 对我院近 24年产科子宫切除术作回顾性分析。结果: 产科子宫切除术发生率为 0 .079%, 其中, 剖宫产子宫切除占 80%, 子宫切除术主要指征为胎盘因素和子宫收缩乏力。结论: 做好孕产妇监测和计划生育, 正确掌握剖宫产手术指征, 可以有效地降低产科子宫切除术发生率和围产儿死亡率。     

电视宫腔镜在临床应用的研究

目的:探讨电视宫腔镜检查在临床诊断及治疗的意义及价值。方法:对在我院作电视宫腔镜检查的患者共540例进行分析总结。结果:子宫内膜增殖112例,子宫内膜息肉94例,子宫黏膜下肌瘤102例,子宫内膜癌19例,宫内节育器异常86例,子宫肌壁间肌瘤向宫腔突出52例,正常子宫内膜50例,其他25例。结论:宫腔镜检查可明确诊断异常子宫出血病因,能了解宫内节育器位置,并协助取出。     

Iatrogenic secondary post‐partum haemorrhage: Apropos of two uncommon cases

In this article we would like to highlight uterine pseudoaneurysm as a cause of secondary post‐partum haemorrhage following Caesarean section. We would like to stress Doppler ultrasound scan as the initial screening modality for this condition. We also describe angioembolization as the prudent treatment option for this condition rather than resorting to surgery.     

Early gastric cancer located just above Dieulafoy's ulcer, with massive bleeding

In 2003, a 69-year-old man visited our emergency department because of hematemesis and anemia. Emergency gastroscopy revealed massive bleeding from Dieulafoy's ulcer in the upper body of the stomach. The arterial bleeding was successfully controlled by endoscopic clipping. Blood transfusion and a proton-pump inhibitor were administered and his condition recovered smoothly. Two weeks after the treatment, type IIa early gastric cancer was detected at the previous bleeding point by follow-up endoscopy. He underwent distal gastrectomy with systematic lymph node dissection (D2), and he had no sign of recurrence until 2005. Histopathological examination revealed an early gastric cancer with submucosal invasion located just above the Dieulafoy's disease. The characteristic finding of Dieulafoy's disease was an enlarged and tortuous artery arising from the subserosa, penetrating the muscle layer, and spreading in the submucosa. Abnormal Dieulafoy's artery coexisting with gastric cancer has been reported in only 17 cases until now. Our clinical and pathological findings led us to the following speculation on the pathogenesis in our patient. Repeated regeneration of the mucosal membrane would have been caused by circulatory disturbance in Dieulafoy's vessels. This regeneration and mucosal dysplasia may have been a factor in promoting the gastric cancer. In the previously reported cases of the coexistence of abnormal Dieulafoy's artery and gastric cancer, the initial gastroscopic examination rarely diagnosed the gastric cancer. Thus, follow-up gastroscopy is essential, so as not to miss such coexisting diseases.     

论干姜在血证中的运用

从相关本草著作及方剂出发,对干姜在治疗血证方面的功效特点及其炮制、配伍的用法做了整理.研究发现,干姜可以用于出血、血虚等证,分别起到温中止血、温阳引阴生血以退虚热等作用.     

大肿块ⅠB、ⅡA期及局部晚期宫颈癌的治疗

宫颈癌是全球范围内严重威胁人类身体健康的疾病，也是中国最常见的妇科恶性肿瘤之一。在尚未开展宫颈涂片普查的国家和地区，患者就诊时肿瘤通常已发展至大肿块ⅠB/Ⅱ期或局部晚期宫颈癌。宫颈癌最常应用的分期系统是FIGO分期系统。尽管分期为早期，但大肿块ⅠB/Ⅱ期宫颈癌的预后与局部晚期患者类似，且单纯子宫切除术无法治愈这类患者。外放射后继以腔内近距离放射联合同期DDP为主的化疗可有效提高局部晚期宫颈癌的总生存率。本文将就目前支持联合治疗大肿块ⅠB/Ⅱ期或局部晚期宫颈癌的临床试验结果进行全面评估。     

鼠尾藻多糖的制备及其抗凝血活性的初步研究

目的在对鼠尾藻(Sargassum thunbergiiKuntze)多糖进行脱色精制及氧化降解的基础上,研究其抗凝血活性。方法采用硅藻土脱色、次氯酸钠降解制备鼠尾藻多糖(PST)及其3种降解物,采用剪尾法和毛细管法对其进行抗凝血活性初步研究。结果4种鼠尾藻多糖均能显著延长小鼠的出血时间和凝血时间,3种降解物还能使小鼠的出血量显著增加。结论鼠尾藻多糖具有较强的抗凝血作用,且其抗凝血作用与其相对分子质量有关。