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121.
M. Admiraal W. Medendorp C. Gielen 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2002,142(2):181-192
The three rotational degrees of freedom of the head and the upper arm exceed the number needed in a two-dimensional (2-D) facing or pointing task, respectively. Previous studies reported a reduction of the number of degrees of freedom from three to two, with one degree of freedom being a unique function of the other two (Donders' law). This study investigated whether three-dimensional (3-D) orientations of the head and arm are the same at rest and during movement for corresponding pointing or facing directions. Two separate experiments were performed: one focused on head orientations, the other focused on upper arm orientations. We instructed subjects to direct the nose or to point the extended arm in the direction of targets, which appeared in a quasi-random order at 2-s intervals. The head and upper arm orientations at rest were described by a 2-D surface with a scatter less than 3 or 4 degrees, respectively. Both for the arm and the head, orientations started and ended near the 2-D surface, but for a number of the target pairs, the orientations deviated from those predicted by the 2-D surface during movement in a way that was consistent and reproducible for movements between each target pair. For upper arm movements, we often found that deviations of arm orientations from the 2-D surface increased with increasing movement velocity. Such a positive correlation between deviation and movement velocity was not found for head movements. These results clearly indicate violations of Donders' law during movement and argue against several models for movement control found in the literature. 相似文献
122.
Strategic control and medial frontal negativity: beyond errors and response conflict 总被引:6,自引:0,他引:6
Errors in timed choice tasks typically produce an error-related negativity (ERN) in the event-related potential (ERP). The error specificity of the ERN has been challenged by studies showing a correct response negativity (CRN). Forty-five participants engaged in a flanker task in which both compatibility between flankers and target and the probability of compatible flankers were manipulated. Correct responses elicited a CRN, the amplitude of which increased with the degree of mismatch between the presence of conflict and conflict probability, even on low-conflict (compatible) trials. The fronto-central N2 component was larger on high-conflict (incompatible) correct response trials. However, in contrast to some recent accounts, this N2 was largest for highly probable stimuli. These findings suggest revision to models of the effects of conflict on response-related negativity to account for strategic adjustments made in preparation for the response. 相似文献
123.
To test for metabolic deoxyribonucleic acid (DNA) turnover in differentiating neurons, [methyl-3H]thymidine was injected into the lateral cerebral ventricles of newly born rats, and after 6, 24 and 96 h, neuronal nuclei were prepared from the immature cerebral cortex. Enzymatic treatment converted virtually all of the DNA into soluble deoxynucleosides which were fractionated by high-performance liquid chromatography for determination of specific activity. The specific activity of thymidine was found to decline rapidly with time. The rate of this loss correlated with the radioactivity initially incorporated into the DNA. This suggested that DNA was being replaced by DNA repair as a consequence of radiation damage, rather than by spontaneous metabolic DNA turnover. 相似文献
124.
Jonathan T. Sims Venkatesh Krishnan Ching-Yun Chang Sarah M. Engle Giacomo Casalini George H. Rodgers Nicoletta Bivi Brian J. Nickoloff Robert J. Konrad Stephanie de Bono Richard E. Higgs Robert J. Benschop Silvia Ottaviani Anabela Cardoso Ajay Nirula Mario Corbellino Justin Stebbing 《The Journal of allergy and clinical immunology》2021,147(1):107-111
125.
Dr. M. J. Kelly U. Kuhnt W. Wuttke 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1980,40(4):440-447
Summary Intracellular recordings and injections of procion yellow (PY) were made in parvocellular neurons in hypothalamic slices of female guinea pigs. Eighty-five neurons, with an average resting membrane potential of -35 mV, were recorded in the arcuate (ARC) ventromedial (VM), and in the cellpoor zones between the ARC and VM. Eleven of the ARC neurons and four neurons from the cell-poor zone could be driven antidromically by median eminence (ME) stimulation, nine other neurons from the three areas could be driven orthodromically by stria terminalis (ST) stimulation.Twenty-eight parvocellular neurons were tested with 17 -estradiol (E2), which was applied in the bathing medium as the free steroid. Eleven neurons (nine ARC and two cell-poor-zone neurons) were hyperpolarized 2 to 24 mV by 10–10 M E2 concentrations. 10–8 M estrone concentration was without effect on three of these cells. Through the intracellular injection of PY, the estrogen-sensitive neurons (N = 11) were identified as small fusiform cells with few dendrites. Spine-like appendages were found on only one of these cells. None of the larger pyramidal-like neurons of these areas responded to the application of E2.Postdoctoral research fellow of the National Institute of Neurological and Communicative Disorders and Stroke 相似文献
126.
Johannes Jrhult Jan Holmberg Jan Lundvall Stefan Mellander 《Acta physiologica (Oxford, England)》1976,97(4):470-475
Changes of the arterial plasma osmolality and of the glucose concentration were followed during a 30 min period of graded hemorrhagic hypotension (80, 50, and 30 mmHg) in the cat. Bleeding evoked a significant plasma hyperosmolality at all three hypotension levels and the responses were quantitatively related to the degree of hypotension. An approximate steady state increase in the arterial plasma osmolality was reached about 20 min after the start of the bleeding and it then averaged 8, 20, and 25 mOsm/kg H2O at 80, 50, and 30 mmHg, respectively. Bleeding also evoked an increase in the plasma glucose concentration, which almost entirely accounted for the observed hyperosmolality, especially at 80 and 50 mmHg. In late stages of hypotension at 30 mmHg, elevated plasma lactate and potassium concentrations contributed to the overall hyperosmolality. — Previous hemorrhagic hypotension experiments at 50 mmHg (Järhult 1975 b) have shown that hyperosmolality serves as an important regulator of the plasma and extracellular fluid volumes during bleeding. The present results indicate that such an osmolar compensatory mechanism is operating over wide ranges of hemorrhagic hypotension. 相似文献
127.
Vascularly isolated hind legs of cold acclimated rats were perfused with arterial blood either without noradrenaline (NA) or with a constant concentration of NA (10 ng·ml–1) at different perfusion rates ranging from 2 to 14l·g–1·min–1. The oxygen consumption of the leg during perfusion both with or without NA was linearly related to the perfusion rate. The linear increase of leg oxygen consumption with respect to the perfusion was steeper after NA, which indicates that the same arterial concentration of NA may produce a greater thermogenic effect at higher blood flow rates (the difference between resting metabolic rate and the thermogenesis stimulated by NA, was 8.20 l O2·g–1·h–1 at a blood flow of 3l·g–1·min–1, compared with 45.02 l O2·g–1·h–1 at a blood flow of 14 l·g–1·min–1). These data confirm the important role of the extravascular influx rate of NA in the control of thermogenesis due to NA in muscles. 相似文献
128.
R. N. Scott R. H. Brittain R. R. Caldwell A. B. Cameron V. A. Dunfield 《Medical & biological engineering & computing》1980,18(1):65-69
Progress in the development of a system to provide sensory feedback of the pinch force of an artificial hand is described.
Design criteria relating to electrocutaneous stimulation and compatibility with myoelectric control are discussed. Details
of a practical system, presently in use by two amputees prior to full-scale clinical evaluation, are presented. 相似文献
129.
Tseng YW Scholz JP Schöner G Hotchkiss L 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2003,149(3):276-288
Given the number of muscles and joints of the arm, more ways are available to produce an identical hand movement when pointing
to a target than are strictly necessary. How the nervous system manages these abundant degrees of freedom was the focus of
this study of pointing to targets of low and high indices of difficulty (ID). Two essential features of movement synergies
were examined. The first reflects the preferred relations among the outputs of each movement element and was studied through
principal component analysis. The second feature of synergy reflects the flexibility of those relationships evidenced by the
use of multiple, goal-equivalent solutions to joint coordination. This second feature, which is the main focus of this report,
was studied using the uncontrolled manifold approach. Motor abundance was defined operationally as the component of variance
of joint combinations that left unchanged the value of important performance variables (goal-equivalent variability, GEV).
This variance component was contrasted with the component of variance leading to a change in the value of these variables
(non-goal-equivalent variability, NGEV). The difference between GEV and NGEV was evaluated with respect to the performance
variables movement extent, movement direction, and path of the arm's center of mass. More than 90% of the variance of joint
motions across the pointing trial were accounted for by one principal component, indicating a consistent temporal coupling
among most joint motions in a single functional synergy. The flexible nature of this synergy was revealed by the variability
analysis. All subjects had significantly higher GEV than NGEV for most of the movement path. Thus, variable patterns of joint
coordination did not represent noise but the use of equivalent coordinative solutions related to stabilizing important performance
variables. Higher GEV than NGEV was present regardless of the task's ID. One exception was at the time of peak velocity, leading
to poorer control of movement extent than movement direction. Increasing the task's ID led to an overall reduction of joint
configuraion variance, particularly GEV. These results support earlier work indicating that the use of goal-equivalent solutions
to joint coordination is a common feature of the control of this and many other motor tasks. Functionally important performance
variables appear to be controlled through flexible but task-specific coordination among the motor elements
Electronic Publication 相似文献
130.
Rats were trained to press a lever under a variable-interval (VI) schedule of water reinforcement. After stable responding had developed, a 4.5-KHz tone (CS) was conditioned classically to a 2.5-mA electric shock (US) in groups of animals which had been given various psychoactive drugs or saline. Twenty-four hours later, a stimulus generalization test was conducted in the absence of drug; during this session, tones that varied in frequency around 4.5 KHz were presented while the animals were responding under the VI schedule. In animals conditioned under saline, all tones (non-differentially) suppressed responding which, however, recovered gradually over time. This suppressive effect was eliminated by lysergic acid diethylamide (LSD; 0.2 and 0.32 mg/kg), cocaine (20 mg/kg), diazepam (2.5 mg/kg), lisuride (0.08 mg/kg), mescaline (20 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (4 mg/kg), and was attenuated by amphetamine (4 mg/kg), pentobarbital (15 mg/kg) and morphine (4 mg/kg). Atropine (10 mg/kg), scopolamine (1 mg/kg), clonazepam (0.5 mg/kg), and chlorpromazine (4 mg/kg) did not alter the suppressive effect of the tone. The serotonin antagonist BC-105 (6 mg/kg) reversed the effect of 0.2 mg/kg of LSD. These results suggest (1) that drug-induced stimuli may overshadow other (e.g., external) stimuli during classical conditioning and, (2) that drugs might affect behavior by altering processes (stimulus control or others) that do not simultaneously involve response or motor control. 相似文献