全文获取类型
收费全文 | 255624篇 |
免费 | 23012篇 |
国内免费 | 12023篇 |
专业分类
耳鼻咽喉 | 2897篇 |
儿科学 | 5764篇 |
妇产科学 | 3378篇 |
基础医学 | 40387篇 |
口腔科学 | 7158篇 |
临床医学 | 21803篇 |
内科学 | 37085篇 |
皮肤病学 | 5663篇 |
神经病学 | 16377篇 |
特种医学 | 5349篇 |
外国民族医学 | 142篇 |
外科学 | 21703篇 |
综合类 | 40632篇 |
现状与发展 | 58篇 |
预防医学 | 12943篇 |
眼科学 | 6073篇 |
药学 | 21195篇 |
57篇 | |
中国医学 | 8211篇 |
肿瘤学 | 33784篇 |
出版年
2024年 | 607篇 |
2023年 | 3525篇 |
2022年 | 6674篇 |
2021年 | 9206篇 |
2020年 | 8195篇 |
2019年 | 7755篇 |
2018年 | 7909篇 |
2017年 | 8626篇 |
2016年 | 9174篇 |
2015年 | 9937篇 |
2014年 | 15340篇 |
2013年 | 16972篇 |
2012年 | 15141篇 |
2011年 | 16777篇 |
2010年 | 14065篇 |
2009年 | 13388篇 |
2008年 | 13995篇 |
2007年 | 14179篇 |
2006年 | 12876篇 |
2005年 | 11634篇 |
2004年 | 10149篇 |
2003年 | 8797篇 |
2002年 | 7213篇 |
2001年 | 6251篇 |
2000年 | 5186篇 |
1999年 | 4633篇 |
1998年 | 4217篇 |
1997年 | 3763篇 |
1996年 | 3372篇 |
1995年 | 3004篇 |
1994年 | 2578篇 |
1993年 | 2108篇 |
1992年 | 1766篇 |
1991年 | 1577篇 |
1990年 | 1280篇 |
1989年 | 1122篇 |
1988年 | 1021篇 |
1987年 | 811篇 |
1986年 | 735篇 |
1985年 | 994篇 |
1984年 | 870篇 |
1983年 | 596篇 |
1982年 | 658篇 |
1981年 | 494篇 |
1980年 | 443篇 |
1979年 | 313篇 |
1978年 | 218篇 |
1977年 | 168篇 |
1976年 | 130篇 |
1975年 | 60篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
Rosario Gulias-Cañizo Anell Lagunes-Guillén Arturo González-Robles Erika Sánchez-Guzmán Federico Castro-Muñozledo 《Burns : journal of the International Society for Burn Injuries》2019,45(2):398-412
Background
Since recent reports have shown that (-)-Epigallocatechin-3-gallate (EGCG) could be used for treating proliferative and inflammatory disorders, we explored its use for the management of corneal chemical burns.Materials and methods
Initially, EGCG was assayed on the rabbit corneal epithelial cell line RCE1(5T5) to establish the best testing conditions, and to avoid unwanted outcomes in the experimental animals. Then, we studied its effects on cell proliferation, cell cycle progression and cell differentiation. Afterwards, we instilled EGCG in experimental grade II corneal alkali burns in mice, three times a day up to 21 days, and evaluated by slit lamp examination and histological sections of corneal epithelial, corneal endothelial and stromal edema, as well as the presence of inflammatory cells and neovascularization.Results
EGCG reduced cell growth and led to a decline in the proportion of proliferative cells in a concentration dependent manner. At 10 μM, EGCG promoted cell differentiation, an effect not related with apoptosis or cytotoxicity. When 10 μM EGCG was instilled in corneal alkali burns in mice three times a day up to 21 days, EGCG significantly reduced corneal opacity and neovascularization. The improved clinical appearance of the cornea was associated to a controlled epithelial growth; epithelial morphology was similar to that observed in normal epithelium and contrasted with the hyperproliferative, desquamating epithelium observed in control burn wounds. EGCG reduced corneal, stromal and endothelial edema, and wound inflammation.Conclusion
This work constitutes the first evidence for the use of EGCG in the acute phase of a corneal alkali burn, representing a possible novel alternative to improve patient outcomes as an add-on therapy. 相似文献12.
《Mayo Clinic proceedings. Mayo Clinic》2019,94(7):1321-1329
Immune checkpoint inhibitors are molecules that increase the endogenous immune response against tumors. They have revolutionized the field of oncology. Since their initial approval for the treatment of advanced melanoma, their use has expanded to the treatment of several other advanced cancers. Unfortunately, immune checkpoint inhibitors have also been associated with the emergence of a new subset of autoimmune-like toxicities, known as immune-related adverse events. These toxicities differ depending on the agent, malignancy, and individual susceptibilities. Although the skin and colon are most commonly involved, any organ may be affected, including the liver, lungs, kidneys, and heart. Most of these toxicities are diagnosed by excluding other secondary infectious or inflammatory causes. Corticosteroids are commonly used for treatment of moderate and severe immune-related adverse events, although additional immunosuppressive therapy may occasionally be required. The occurrence of immune-related toxicities may require discontinuation of immunotherapy, depending on the specific toxicity and its severity. In this article, we provide a focused review to familiarize practicing clinicians with this important topic given that the use of immune checkpoint inhibitors continues to increase. 相似文献
13.
14.
Very preterm children are at increased risk of reduced processing speed at 5 years of age,predicted by typical complications of prematurity and prenatal smoking 下载免费PDF全文
15.
Using JEG-3 and BeWo cells, we examined the effect of “real life” mixtures of polycyclic aromatic hydrocarbons (PAHs), at doses reported in maternal blood (Mix I) and in placental tissue (Mix II), on human chorionic gonadotropin (hCG), placental lactogen (hPL) and placental growth factor (hPLGF) secretion, protein expression and immunolocalization. Additionally, the action of PAH mixtures on basal and hormone-stimulated matrix metalloproteinase-2 (MMP-2), MMP-9 and vascular endothelial growth factor (VEGF) protein expression was evaluated. Under basal conditions, the PAH mixtures increased hCG and decreased hPLGF levels in both cell lines, while hPL expression was stimulated in JEG-3 and inhibited in BeWo. There was no effect on the MMP-2/MMP-9 ratio or VEGF expression. In hormone-stimulated cells, PAH mixtures changed the MMP-2/MMP-9 ratio in JEG-3 cells in favor of MMP-9, while in BeWo MMP-2 was favored. The effect on VEGF expression was cell specific and dependent on the mixture. In hCG-treated cells, only Mix II inhibited VEGF expression in JEG-3 cells. Neither PAH mixtures affected this protein in BeWo cells. In hPL-treated cells, Mix I had a stimulatory effect in JEG-3 cells, while Mix II exerted an inhibitory effect in BeWo cells. In hPLGF-treated cells, Mix II decreased in JEG-3 cells, but in BeWo cells, both mixtures increased VEGF expression. Considering that the evaluated protein hormones play crucial roles in angiogenesis and neovascularization in the placenta, “real life” PAH mixtures by disrupting protein hormones levels, the MMP-2/MMP-9 ratio and VEGF expression can lead to insufficiency and many pregnancy-related disorders. 相似文献
16.
17.
18.
俞海燕 《浙江中西医结合杂志》2019,29(10)
<正>机体的血钾参与并维持细胞代谢,保持细胞内液渗透压及酸碱平衡,并可维持神经肌肉组织兴奋及心肌功能~([1-2])。中重度低血钾主要表现为肌无力,可延及机体的躯干和呼吸肌,造成呼吸困难,还可引发腱反射减弱或消失、肠麻痹及心脏传导阻滞、节律异 相似文献
19.
20.