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61.
Chun Yuan Jay S. Tsuruda Kirk N. Beach Cecil E. Hayes Marina S. Ferguson Charles E. Alpers Thomas K. Foo D. Eugene Strandness 《Journal of magnetic resonance imaging : JMRI》1994,4(1):43-49
Atherosclerotic cardiovascular disease is the most common cause of death in the United States. Investigation of atherosclerotic plaque morphology and composition is important because the findings may be useful in predicting prognosis or response to therapy. This study presents high-resolution magnetic resonance (MR) imaging techniques developed on a 1.5-T whole-body imager with a custom-built surface coil, for characterizing the composition and morphology of plaque removed at carotid endarterectomy. The initial comparison of MR imaging and histologic results showed good correlation. In conjunction with MR angiography, these techniques could be used in in vivo imaging to define the size, location, and contents of atherosclerotic plaque at the carotid bifurcation. 相似文献
62.
Sylvie Destian M.D. Howard Tung M.D. Richard Gray M.D. David R. Hinton M.D. John Day M.D. Takanori Fukushima M.D. 《Surgical neurology》1994,41(6):472-476
Infectious intracavernous carotid artery aneurysms usually present with ophthalmoplegia and/or signs of cavernous sinus thrombosis. We report an unusual case in which a patient with AIDS presented with intractable epistaxis secondary to rupture of a giant infectious intra-cavernous carotid artery aneurysm. Culture of the aneurysm grew mycobacterium avium intracellulare (MAI). The patient was treated successfully by excision of the aneurysm and reconstruction of the internal carotid artery with a saphenous vein interposition graft. 相似文献
63.
年轻人冠状动脉壁平滑肌细胞的表型变化及其与巨噬细胞的关系——免疫组织化学研究 总被引:1,自引:0,他引:1
选用年轻人冠状动脉材料,免疫组织化学方法,观察了弥漫性内膜增厚、脂纹、动脉粥样硬化斑块中平滑肌细胞的免疫表型变化,并将这些变化同巨噬细胞进行了联系。结果表明,凡是有巨噬细胞浸润之处,不管何种病变,该处的平滑肌细胞便失去了相应抗体的反应性,但仍能被抗间叶细胞抗体所标记,提示平滑肌细胞已经发生表型转变。这一现象说明巨噬细胞在平滑肌细胞表型转变过程中起重要作用,有助于人们对动脉粥样硬化病变、冠脉成形术后再狭窄病变发生过程的认识。 相似文献
64.
缺血性脑血管病与颈动脉粥样硬化及其危险因素的关系 总被引:17,自引:0,他引:17
目的探讨缺血性脑血管病(ICVD)与颈动脉粥样硬化及其危险因素的关系。方法对186例ICVD患者与194例非脑血管病患者和正常体检者(对照组)行颈部血管超声检查和血液生化检查;比较两组间的颈动脉硬化程度及脑卒中危险因素的差异。结果ICVD组年龄[(69±7)岁]和患有高血压(66.1%)、糖尿病(53.4%)、代谢综合征患者(44.6%)的比率非常明显高于对照组[(61±5)岁、48.8%、15.2%、12.9%](均P<0.001)。ICVD组颈动脉粥样硬化分级计分≥2分(斑块发生率)、≥3分(血管狭窄发生率)分别为69.3%、20.4%,明显高于对照组的33.5%和5.1%(均P<0.05)。结论颈动脉粥样硬化是ICVD的危险因素之一;各种危险因素的聚集对ICVD的发生起重要作用。 相似文献
65.
Louis G. Martin M.D. Randy D. Cork James O. Wells 《Cardiovascular and interventional radiology》1993,16(2):76-80
Two hundred forty-four consecutive patients (mean age 61 years), including 123 who had technically valid renal vein renin
(RVR) analysis and 121 without RVR data, underwent technically successful percutaneous renal artery angioplasty (PTRA). They
were retrospectively examined to evaluate the utility of RVR analysis in identifying renal hypertension (RVH), predicting
benefit from PTRA, and determining if the lack of knowledge of renin levels significantly affected clinical outcome after
PTRA. Abnormal RVR values were associated with clinical benefit after PTRA in 62 of 93 patients (67% sensitivity, 20% specificity,
72% positive predictive value). Clinical improvement following PTRA occurred in 31 of 37 patients with normal pre-PTRA RVR
values (16% negative predictive value). RVR analysis correctly identified 86 of 117 patients with renovascular hypertension
(74% sensitivity, 16% negative predictive value). Improved blood pressure (BP) control occurred in 72% with abnormal RVR analysis
and 66% of the 121 patients without RVR data (p>0.1). We conclude that the very low negative predictive value significantly
limited the use of RVR analysis in this elderly (mean age 60 years) patient population with a high incidence of mild renal
functional impairment (mean serum creatinine 1.4 mg/dl) and bilateral renal artery stenosis (38%). The lack of pre-PTRA renin
data did not significantly affect clinical outcome. If RVR data were relied upon as the exclusive selection criterion in patients
of this type, many would be prevented from having the benefit of cure or improvement by PTRA. 相似文献
66.
大动脉炎颈动脉狭窄球囊扩张和内支架的治疗 总被引:2,自引:1,他引:1
目的:探讨应用球囊扩张和血管内支架治疗大支脉炎、颈动脉狭窄、材料和方法:3例大动脉炎性颈动脉狭窄的患者,狭窄段均超过8cm,1例单纯球囊扩张;2例球囊扩张后植入Wallstent支架。结果:术后狭窄率均为0,达到了良好的治疗效果,单纯球囊扩张的动脉一年后动脉完全闭塞、西入血管内支架的2例,分别是在4.5个月和4个月检查,一例血管内支架的近端出现了再狭窄,另一例未出现再狭窄。结论:对于大动脉炎性长段 相似文献
67.
目的 探讨颈动脉斑块患者发生前循环缺血性卒中的临床及多模态超声(multimodal ultrasound, MMU)影响因素,构建基于超微血流成像技术(superb microvascular imaging, SMI)的风险分层预测模型。方法 回顾性分析颈动脉斑块患者683例,根据临床表现和多层螺旋电子计算机断层扫描(computed tomography, CT)/核磁共振扫描(magnetic resonance imaging, MRI),分为前循环卒中组(n=301)和非前循环卒中组(n=382)。收集患者颈动脉斑块的MMU特征、临床和实验室检查数据,采用多因素二元Logistic回归分析筛选出前循环缺血性卒中的影响因素。构建列线图风险预测模型,进行模型验证与风险分层。结果 前循环卒中组和非前循环卒中组年龄、体重指数(body mass index, BMI)、饮酒史、吸烟史、脑梗死既往史、高血压、糖尿病、低密度脂蛋白(low-density lipoprotein, LDL)、高密度脂蛋白(high-density lipoprotein, HDL)、同型半胱氨酸(hom... 相似文献
68.
目的 探讨糖尿病肾病(DN)患者血清瞬时受体电位通道7(TRPM7)、沉默调节蛋白-1(Sirtuin-1)与钙磷代谢、颈动脉钙化的相关性。方法 选取2020年12月—2022年11月成都大学附属医院收治的97例DN患者作为DN组,另取同期在该院就诊的120例2型糖尿病患者作为对照组。采用实时荧光定量聚合酶链反应检测血清TRPM7的表达,酶联免疫吸附试验检测血清Sirtuin-1水平。采用Pearson法分析DN患者血清TRPM7、Sirtuin-1水平与钙磷代谢的相关性,并通过多因素Logistic逐步回归模型分析DN患者颈动脉钙化的危险因素。结果 DN组血肌酐、尿素氮、血清TRPM7、血磷、颈动脉钙化率高于对照组(P <0.05)。DN组Sirtuin-1、血钙低于对照组(P <0.05)。Pearson相关性分析结果显示,DN患者血清TRPM7与血钙呈负相关(r=-0.247,P=0.000),与血磷呈正相关(r=0.415,P=0.000);DN患者血清Sirtuin-1与血钙呈正相关(r=0.367,P=0.000),与血磷呈负相关(r=-0.505,P=0.00... 相似文献
69.
目的 探讨血清鸢尾素及脂联素(APN)水平与颈动脉粥样硬化的关系。方法 选取2020年1月—2022年1月海南省人民医院收治的124例H型高血压患者作为研究组,另选取同期来该院体检的健康者112例作为对照组。比较两组血清鸢尾素、APN水平,分析研究组颈动脉粥样硬化斑块形成的影响因素,采用受试者工作特征(ROC)曲线分析血清鸢尾素、APN水平预测颈动脉粥样硬化斑块形成的价值。结果 研究组血清鸢尾素、APN水平低于对照组(P <0.05)。斑块形成组与非斑块形成组性别、年龄、体重指数、吸烟史、饮酒史、收缩压、舒张压、血压控制良好、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、一氧化氮、尿酸、肌酐、内皮素水平比较,差异无统计学意义(P>0.05)。斑块形成组甘油三酯、同型半胱氨酸水平高于非斑块形成组(P <0.05),鸢尾素、APN水平低于非斑块形成组(P <0.05)。多因素一般Logistic回归分析结果显示:同型半胱氨酸水平[■=4.415(95%CI:1.817,10.730)]、血清鸢尾素水平[■=4.027(95%CI:1.657,9.787)]、AP... 相似文献
70.
In humans, electrical, bipolar, bilateral carotid sinus nerve stimulation (CSNS; impulse duration 0.35 ms) was applied, using frequencies between 10 and 110 Hz and voltages between individual thresholds and maximal amplitudes of stimulation. Ten anginal patients and two hypertensive patients were studied at an interval of up to 12 years after implantation of electrodes and a radiofrequency receiver for chronic therapeutic CSNS. In search of combinations of frequency and voltage of CSNS, eliciting largest ("optimal") depressor responses of blood pressure and heart rate in the individual patient, Rechenberg's evolution strategy was applied. This strategy simulates mutation and selection of biological evolution. In each patient and on each test stimulation, a value of quality was computed from actual heart rate and blood pressure values as a selection criterion for the strategy. Either responses to uninterrupted CSNS were investigated, while stimulation parameters were adjusted every 3 min, according to the strategy, or responses to 3 min of CSNS after a change in stimulation parameters were compared to intercalated 3-min control periods. In each patient, one or more combined settings of frequency and voltage elicited "optimal" responses. In principle, "optimal" CSNS frequencies ranged between 35 and 105 Hz with large interindividual differences. Due to chronic implantation of electrodes and technical features of radiofrequency transmitted stimulation energy, interindividually different voltages led to an optimal response to CSNS. Also according to the present results, the frequency of CSNS has to be determined individually. It is concluded that the evolution strategy was applied successfully, because voltage and frequency settings leading to "optimal" responses were found within 90-180 min, whereas intraindividual systematic investigations would not be feasible due to their necessarily very long duration. So far, only short-term responses have been evaluated. A broader use of the strategy in other applications is encouraged, as for example in pacemaker optimization and especially in functional electrostimulation. 相似文献