Early postoperative fever workup in children: utilization and utility

Background

Early postoperative fever is common. Adult data indicate that workup is unnecessary in the early postoperative period, but comparable data in children is limited. The objectives are to determine the incidence of fever and the utilization and yield of tests ordered in children.

MicroRNA-125b Accelerates and Promotes PML-RARa-driven Murine Acute Promyelocytic Leukemia

ObjectiveMost acute promyelocytic leukemia cases are characterized by the PML-RARa fusion oncogene and low white cell counts in peripheral blood.MethodsBased on the frequent overexpression of miR-125-family miRNAs in acute promyelocytic leukemia, we examined the consequence of this phenomenon by using an inducible mouse model overexpressing human miR-125b.ResultsMiR-125b expression significantly accelerates PML-RARa-induced leukemogenesis, with the resultant induced leukemia being partially dependent on continued miR-125b overexpression. Interestingly, miR-125b expression led to low peripheral white cell counts to bone marrow blast percentage ratio, confirming the clinical observation in acute promyelocytic leukemia patients.ConclusionThis study suggests that dysregulated miR-125b expression is actively involved in disease progression and pathophysiology of acute promyelocytic leukemia, indicating that targeting miR-125b may represent a new therapeutic option for acute promyelocytic leukemia.     

地氟醚与七氟醚对颅脑肿瘤手术患者血糖和乳酸的影响

目的研究地氟醚与七氟醚对颅脑肿瘤手术患者血糖和乳酸的影响。方法选择择期行颅脑肿瘤切除的患者64例,年龄21～62岁,ASA分级Ⅰ～Ⅱ级,体质指数20～25 kg/m2,采用随机数字表法分为地氟醚组(Group Des,n=30)与七氟醚组(Group Sevo,n=34),分别采用地氟醚、七氟醚吸入麻醉。分别于手术前(T0)、手术1小时(T1)、手术2小时(T2)、手术结束(T3)取动脉血1 m L,检测血糖和乳酸水平。结果两组患者血糖均升高,在四个不同时间点的比较差异有统计学意义(P0.01);各组在各时间点的比较无统计学意义(P0.05)。两组患者乳酸无明显升高,在各时间点的比较无统计学意义(P0.05);各组在各时间点的比较无统计学意义(P0.05)。结论地氟醚与七氟醚麻醉均增加颅脑肿瘤患者血糖水平。