全文获取类型
收费全文 | 2661篇 |
免费 | 517篇 |
国内免费 | 215篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 7篇 |
妇产科学 | 10篇 |
基础医学 | 448篇 |
口腔科学 | 80篇 |
临床医学 | 124篇 |
内科学 | 360篇 |
皮肤病学 | 28篇 |
神经病学 | 228篇 |
特种医学 | 41篇 |
外科学 | 148篇 |
综合类 | 452篇 |
现状与发展 | 2篇 |
预防医学 | 69篇 |
眼科学 | 82篇 |
药学 | 497篇 |
中国医学 | 269篇 |
肿瘤学 | 546篇 |
出版年
2024年 | 57篇 |
2023年 | 183篇 |
2022年 | 290篇 |
2021年 | 376篇 |
2020年 | 294篇 |
2019年 | 247篇 |
2018年 | 204篇 |
2017年 | 226篇 |
2016年 | 232篇 |
2015年 | 287篇 |
2014年 | 259篇 |
2013年 | 218篇 |
2012年 | 168篇 |
2011年 | 105篇 |
2010年 | 86篇 |
2009年 | 59篇 |
2008年 | 36篇 |
2007年 | 16篇 |
2006年 | 9篇 |
2005年 | 3篇 |
2004年 | 9篇 |
2003年 | 3篇 |
2002年 | 2篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1989年 | 4篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 3篇 |
1984年 | 2篇 |
1978年 | 1篇 |
排序方式: 共有3393条查询结果,搜索用时 62 毫秒
61.
The health benefits of specific fatty acids and physiological roles of fat metabolism are important subjects that are still poorly understood. In this issue of Genes & Development, O''Rourke and colleagues (pp. 429–440) uncovered a role for lipase-generated ω-6 fatty acids in promoting autophagy and, consequently, life span extension under both fed and fasting conditions. The impact of this finding is discussed with regard to the nutritional value of ω-6 fatty acids and regulatory functions of fat metabolism beyond its well-known role in energy storage. 相似文献
62.
Karla Consort Ribeiro Roberto Perez Campelo Daniela del Rosário Flores Rodrigues Elisabete C. Mattos Izaira Trincani Brandão Célio Lopes da Silva 《Autoimmunity》2013,46(5):245-257
AbstractAutoantibodies against the M2 subtype of muscarinic acetylcholine receptors with functional activities have been found in the sera of patients with dilated cardiomyopathy (DCM), and the second extracellular loop has been established as the predominant epitope. However, it has been shown that the third intracellular loop is recognized by Chagas disease patients with severe cardiac dysfunction. In this work, BALB/c mice were immunized with plasmids encoding these two epitopes, and a control group received the empty plasmid (pcDNA3 vector). Serum from these DNA-immunized animals had elevated and persistent titres of antibodies against respective antigens. Heart echocardiography indicated diminished left ventricular wall thickness and reduced ejection fraction for both epitope-immunized groups, and ergospirometry tests showed a significant decrease in the exercise time and oxygen consumption. Transfer of serum from these immunized mice into naïve recipients induced the same alterations in cardiac structure and function. Furthermore, electron microscopy analysis of donor-immunized animals revealed several ultrastructural alterations suggestive of autophagy and mitophagy, suggesting novel roles for these autoantibodies. Overall, greater functional and structural impairment was observed in the donor and recipient epitope groups, implicating the third intracellular loop epitope in the pathological effects for the first-time. Therefore, the corresponding peptides could be useful for autoimmune DCM diagnosis and targeted therapy. 相似文献
63.
64.
Michael Feyder PhD Carina Plewnia BSc Ori J. Lieberman BSc Giada Spigolon PhD Alessandro Piccin PhD Lidia Urbina BSc Benjamin Dehay PhD Qin Li PhD Per Nilsson PhD Mikael Altun PhD Emanuela Santini PhD David Sulzer PhD Erwan Bezard PhD Anders Borgkvist PhD Gilberto Fisone PhD 《Movement disorders》2021,36(5):1137-1146
65.
66.
Enriched environment boosts the post-stroke recovery of neurological function by promoting autophagy
Autophagy is crucial for maintaining cellular homeostasis, and can be activated after ischemic stroke. It also participates in nerve injury and repair. The purpose of this study was to investigate whether an enriched environment has neuroprotective effects through affecting autophagy. A Sprague-Dawley rat model of transient ischemic stroke was prepared by occlusion of the middle cerebral artery followed by reperfusion. One week after surgery, these rats were raised in either a standard environment or an enriched environment for 4 successive weeks. The enriched environment increased Beclin-1 expression and the LC3-II/LC3-I ratio in the autophagy/lysosomal pathway in the penumbra of middle cerebral artery-occluded rats. Enriched environment-induced elevations in autophagic activity were mainly observed in neurons. Enriched environment treatment also promoted the fusion of autophagosomes with lysosomes, enhanced the lysosomal activities of lysosomal-associated membrane protein 1, cathepsin B, and cathepsin D, and reduced the expression of ubiquitin and p62. After 4 weeks of enriched environment treatment, neurological deficits and neuronal death caused by middle cerebral artery occlusion/reperfusion were significantly alleviated, and infarct volume was significantly reduced. These findings suggest that neuronal autophagy is likely the neuroprotective mechanism by which an enriched environment promotes recovery from ischemic stroke. This study was approved by the Animal Ethics Committee of the Kunming University of Science and Technology, China(approval No. 5301002013855) on March 1, 2019. 相似文献
67.
68.
69.