全文获取类型
收费全文 | 53385篇 |
免费 | 4337篇 |
国内免费 | 1658篇 |
专业分类
耳鼻咽喉 | 351篇 |
儿科学 | 293篇 |
妇产科学 | 254篇 |
基础医学 | 2836篇 |
口腔科学 | 743篇 |
临床医学 | 5107篇 |
内科学 | 3231篇 |
皮肤病学 | 615篇 |
神经病学 | 1826篇 |
特种医学 | 1563篇 |
外国民族医学 | 8篇 |
外科学 | 2228篇 |
综合类 | 12354篇 |
现状与发展 | 5篇 |
预防医学 | 6547篇 |
眼科学 | 755篇 |
药学 | 10536篇 |
616篇 | |
中国医学 | 7401篇 |
肿瘤学 | 2111篇 |
出版年
2024年 | 240篇 |
2023年 | 769篇 |
2022年 | 1778篇 |
2021年 | 2479篇 |
2020年 | 2613篇 |
2019年 | 1392篇 |
2018年 | 1337篇 |
2017年 | 1952篇 |
2016年 | 2565篇 |
2015年 | 2323篇 |
2014年 | 4993篇 |
2013年 | 4496篇 |
2012年 | 4112篇 |
2011年 | 3810篇 |
2010年 | 2883篇 |
2009年 | 2426篇 |
2008年 | 2251篇 |
2007年 | 2417篇 |
2006年 | 2082篇 |
2005年 | 1784篇 |
2004年 | 1332篇 |
2003年 | 1242篇 |
2002年 | 1043篇 |
2001年 | 926篇 |
2000年 | 690篇 |
1999年 | 634篇 |
1998年 | 502篇 |
1997年 | 439篇 |
1996年 | 402篇 |
1995年 | 380篇 |
1994年 | 339篇 |
1993年 | 276篇 |
1992年 | 274篇 |
1991年 | 236篇 |
1990年 | 221篇 |
1989年 | 213篇 |
1988年 | 205篇 |
1987年 | 152篇 |
1986年 | 153篇 |
1985年 | 187篇 |
1984年 | 145篇 |
1983年 | 98篇 |
1982年 | 115篇 |
1981年 | 78篇 |
1980年 | 60篇 |
1979年 | 79篇 |
1978年 | 55篇 |
1977年 | 60篇 |
1976年 | 45篇 |
1975年 | 38篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
Plasma concentrations and bioavailability of propranolol by oral, rectal, and intravenous administration in man 总被引:2,自引:0,他引:2
E Cid F Mella L Lucchini M Cárcamo J Monasterio 《Biopharmaceutics & drug disposition》1986,7(6):559-566
Eight normal male volunteers received 80 mg doses of propranolol by the oral and rectal routes and 2.2 mg by intravenous administration in a crossover fashion. Plasma concentrations of propranolol were measured by a gas chromatographic method using an electron capture detector. Individual subject concentration-time data were analysed and results indicated that the data fit a two compartment model with first order absorption. An approximately two-fold higher plasma propranolol concentration was observed after rectal administration as compared with oral dosing. Statistical analysis of the difference in the total AUCs indicates a significantly higher bioavailability of propranolol administered by the rectal route. The reduced bioavailability after oral administration indicates a substantial first pass effect but that it is possible to bypass the liver, at least partially, by giving the drug rectally to man. 相似文献
52.
目的了解头孢菌素导致抗生素相关性腹泻的基本情况。方法对64例头孢菌素致抗生素相关性腹泻进行临床观察。结果本组头孢菌素致抗生素相关性腹泻以6个月~3岁年龄组发生率最高。其中第3代头孢菌素所致抗生素相关性腹泻的腹泻程度重于第1代。临床表现和实验室检查均缺乏特异性。结论头孢菌素致抗生素相关性腹泻比较常见,应引起临床医师在用药时的重视。 相似文献
53.
Thomas Abel William C. Cockerham Guenther Lueschen Gerhard Kunz 《Social science & medicine (1982)》1989,28(12):1269-1274
This paper examines whether American males with a high degree of control over their work situation pursue healthy lifestyles and rate their physical health more positively than those who score low on occupational self-direction. That is, are persons who control their work more likely to also try to control their health through living in a particularly healthy manner? We found that there was no support for a spillover effect from high occupational self-direction to enhanced participation in health lifestyles or more positive self-rated health. The findings suggest health lifestyles have spread throughout occupational work groups in the U.S. and support research that maintains such lifestyles have spread across social strata in America. 相似文献
54.
目的:观察高压氧结合针灸治疗脑外伤患者的疗效。方法:对96例脑外伤患者采用高压氧、针灸配合药物进行综合治疗。同时,对83例对照组患者根据病情给予降颅压、抗感染、改善脑供血、保护脑细胞等治疗,有手术指征者行清除血肿、减压和清创术。结果:出院时两组患者功能比较,治疗组明显优于对照组,有显著性差异(P<0.O1),疗效治疗组也明显好于对照组。结论:高压氧结合针灸治疗能够明显提高脑损伤患者疗效,对肢体功能有明显提高。 相似文献
55.
56.
目的 评价善宁对顽固性大咯血的疗效。方法 将55例传统药物抢救无效或有禁忌的大咯血分为治疗组(善宁)与对照组(立止血组),观察24—72h的止血效果。结果 治疗组总有效率为92%,对照组为70%,两组比较有显著差异p〈0.05(x^2=4.125)。结论 善宁治疗大咯血疗效显著,使用安全,不良反应少,值得临床推广应用。 相似文献
57.
Two experiments investigated the effects of haloperidol (0.1 mg/kg) on the partial reinforcement extinction effect (PREE). In experiment 1 two groups of rats were trained to run in a straight alley using six trials/day with an intertrial interval (ITI) of 5–8 min. The continuously reinforced (CRF) group received food reward on every trial. The partially reinforced (PRF) group was rewarded on a quasi-random 50% schedule. All animals were then tested in extinction. Haloperidol was administered in a 2 × 2 design, i.e., drug-no drug in acquisition and drug-no drug in extinction. In experiment 2 two groups of rats were trained to press a lever in an operant chamber using a discrete trial procedure of ten trials/day with an ITI of 60 s. The CRF group was rewarded on each trial and the PRF group was rewarded on a quasi-random 50% schedule. Haloperidol was administered for 22 days prior to the start of the PREE procedure as well as throughout acquisition and extinction. The PREE, i.e., increased resistance to extinction of PRF as compared to CRF animals, was obtained in both experiments in all drug conditions. In both experiments haloperidol increased the rate of extinction. Experiment 1 revealed that this effect was entirely dur to the administration of the drug in extinction, independently of the drug condition in acquisition. In contrast to previous results in a one trial/day procedure, the administration of haloperidol to CRF animals did not increase resistance to extinction, failing to support the notion that neuroleptics attenuate the rewarding properties of reinforcement. 相似文献
58.
C. H. van der Meyden J. F. K. de Villiers B. D. Middlecote J. Terblanchè 《Neuroradiology》1994,36(3):221-223
A 9-year-old boy presented with a subacute history of optic neuritis followed by brainstem involvement, with fever and a lymphocytic pleocytosis in the cerebrospinal fluid. Gadolinium-enhancing ring lesions were demonstrate in the white matter of the cerebrum, brainstem and cerebellum on day 17 of the illness, all appearing simultaneously as part of a monophasic illness. A parietal lesion exerted mass effect. Needling and biopsy yielded no evidence of a pyogenic lesion, tumour or tuberculosis and showed vasculitis. There was insufficient material for myelin staining. Dexamethasone therapy lead to rapid improvement of the radiological lesions: MRI and CT on day 34 of the illness showed complete clearing of the lesions except for residual abnormality at the biopsy site. 相似文献
59.
66例成人原发肾病综合征临床治疗与病理分析 总被引:1,自引:0,他引:1
本对66例原发肾病综合征患进行病理类型与临床疗效分析。最常见病理类型为系膜增殖性肾炎,占42.5%,其次为膜性肾病,占32.5%,IgA肾病占15.0%。微小病变型及系膜增殖性肾炎对激素及免疫抑制剂治疗效果好,膜性肾病治疗效果差。不同病理类型患病理损害程度与疗效相关。伴肾小管间质病变治疗效果差(P〈0.05)。NSⅠ型疗效明显优于NSⅡ型(P〈0.05)。50岁以下原发肾病综合征(PNS) 相似文献
60.
电动秋千的研制及其在前庭功能研究中的应用 总被引:1,自引:0,他引:1
本文介绍了带转椅的电动秋千的研制及其使用,包括其工作原理、结构与控制系统的设计、主要技术性能及其在前庭功能与空间运动病研究中的应用。多年的实验证明,这台电动秋千设计合理,技术指标先进,使用性能良好,是研究前庭功能和空间运动病的实用设备。 相似文献