头风痛胶囊治疗头风病(偏头痛)风瘀证临床观察附:62例病例报告

目的　观察中药四类新药头风痛胶囊治疗头风病 (偏头痛 )风瘀证的临床疗效及安全性。方法　采用随机对照试验 ,将 6 2例病人随机分为治疗组和对照组 ,每组 31例 ,分别服用头风痛胶囊和头风痛丸 ,疗程 1月 ,观察其疗效和副作用。结果　治疗组的头痛疗效为显效率 6 4 5 2 %、有效率 87 10 % ;中医证候疗效为显效率 6 1 2 9%、有效率 90 32 %。两组疗效之差异无统计学意义 (P >0 0 5 )。临床试验期间未发现头风痛胶囊所致的不良反应。结论　头风痛胶囊有较好的祛风止痛作用 ,服用安全 ,与头风痛丸具有相同的疗效 ,是头风痛丸的理想新剂型     

服用左炔诺孕酮滴丸和妈富隆1年对血压、血糖和血脂的影响

目的：观察第二、三代口服避孕药(COC)对育龄妇女体重指数、血压、血糖和血脂的影响。方法：将自愿服用COC避孕1年的妇女105例随机分为两组，其中54例给予第二代COC(EE／LNG组)，51例给予第三代COC(EE／DG组)。并对研究前后所有病例的体重指数(BMI)、血压、血糖和血脂代谢指标进行比较分析。结果：EE／LNG组：BMI、收缩压、舒张压、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)和载脂蛋白B(ApoB)水平均升高，高密度脂蛋白(HDL)水平下降，血糖、载脂蛋白AI(ApoAI)水平无明显改变。EE／DG组收缩压、TG、HDL水平升高，BMI、舒张压、血糖、TC、LDL、ApoAI和ApoB均未发生显著变化。以上所有测量指标均未超出正常范围。结论：使用1年第二、三代COC对妇女BMI、血压和血脂代谢都有微弱的影响，对空腹血糖无明显影响。第三代COC对妇女BMI、收缩压、舒张压、TG、TC、LDL、HDL水平和ApoB的不利影响小于第二代，更加安全可靠。     

复方保元煎对绝经后CHD患者脂代谢和血流变影响的研究

目的:研究复方保元煎对绝经后冠心病(CHD)患者脂代谢、血流变的影响。方法:观察180例患者,随机分为治疗组102例,对照组78例。治疗组采用中药复方保元煎治疗,对照组采用维尼安治疗,分别于治疗前后测定脂代谢、血流变指标。结果:治疗后两组脂代谢、血流变指标均有不同程度的改变。治疗组在降低总胆固醇(TC)、甘油三酯(TG),低密度脂蛋白(LDL-C)、载脂蛋白B(apoB)、血流变指标优于对照组(P<0.05或P<0.01)。结论:复方保元煎能改变血脂代谢、调节血黏度,对预防和逆转绝经后的CHD的发生和发展有积极的治疗作用。     

MRI in subacute combined degeneration

We describe a patient with clear lesions in the spinal cord on MRI due to subacute combined degeneration. T2-weighted images clearly showed abnormal high signals in the posterior columns, which disappeared on recovery from the disease.     

Antibody-dependent neutrophil-mediated parasite killing in non-lethal rodent malaria

The effects of administrating recombinant human granulocyte colony-stimulating factor (rhG-CSF) and passively transferring immune serum on infection with an attenuated variant of Plasmodium berghei XAT (Pb XAT), in severe combined immunodeficiency (SCID) mice were examined. In immune competent (C.B-17) mice, the attenuated parasite infection was inevitably self-resolving and degenerating forms inside erythrocytes appeared, coinciding with the drop in parasitaemia, whereas SCID mice were unable to control parasite growth and all the mice died. Continuous administration with rhG-CSF caused neutrophilic granulocytosis in both SCID and C.B-17 mice. The effect of rhG-CSF on the infection in C.B-17 mice was to suppress the course of the parasitaemia at an early phase whereas it had no effect in SCID mice. When immune serum was transferred on the day of infection, the prepatent period was prolonged two days in both SCID and C.B-17 mice. When administration with rhG-CSF was combined with transfer of immune serum, SCID mice showed four days delay in patency and degenerating parasites were seen during the course of parasitaemia, although the infection was ultimately fatal. C.B-17 mice similarly treated showed a seven day delay in the onset of the patent parasitaemia which was of a lesser magnitude and shorter in duration compared with control mice. On the other hand, when C.B-17 mice were splenectomized three weeks before infection and then treated with rhG-CSF and immune serum, no degenerating parasites were seen during the infection and all mice died with high parasitaemias. These results show that antibody-dependent neutrophil-mediated parasite killing may occur in the spleen of mice infected with P. berghei XAT.     

微波与X线联合辐射对人体血液系统的影响

本文调查了微波与X线同时接触工人49名(联合组)、单微波接触工人48名(微波组)以及两者均不接触的工人46名(对照组)。联合组和微波组工人的微波辐射剂量每日平均约300μw/cm~2,联合组工人接触的X线剂量,每年小于5rem。结果显示:联合组中性粒细胞ACP、AKP活性以及中性粒细胞核棘突出现率均较微波组和对照组明显增高(P<0.01),糖原含量则较其它两组明显下降(P<0.01)。调查表明,低强度微波与低剂量X线联合辐射比单独微波辐射对人体的潜在危害更大。因此,对雷达等发射设备周围的工作人员,除必要的微波防护外。同时需要对X线进行防护。     

中药聪脑汤治疗老年性痴呆的临床研究

目的:比较聪脑汤和双益平(石衫碱甲)片剂治疗老年性痴呆(阿尔茨海默病,Alzheimerdisease,AD)的疗效。方法:35例AD病人随机分为2组,聪脑汤组20例,双益平组15例;分别给予聪脑汤50ml,口服,日3次和双益平片剂0.15mg,口服,日2次,两组疗程均为8w。结果:与治疗前相比,两组长谷川痴呆量表(HDS-R)积分均有显著性改善(P<0.05),聪脑汤组和双益平组总有效率分别为75%和73.4%,两组比较差异无显著性。结论:聪脑汤对AD临床症状有一定改善作用。     

骨盆骨折合并阴道损伤（附5例报告）

报告5例女性骨盆骨折合并阴道损伤，占骨盆骨折41例中的12.2%,均为交通事故伤，都合并有失血性休克，开放伤3例，闭合伤2例，治疗作阴道修补术2例，用碘仿纱条填塞阴道2例。未作处理1例，均治愈，阴道损伤表现为四型；横行撕裂伤，纵行撕裂伤，斜行撕裂伤和刺伤，强调早期诊断，及时治疗以防止合并症。     

211例中晚期肺癌的临床疗效分析

本文总结了211例中晚期肺癌的临床治疗效果。按国际四级标准:1年内近期疗效,电化疗的CR、PR有效率为69.2%,中药组为52.5%,中西医结合组为85.3%,后者的疗效优于前两组,P<0.05;远期随访结果:上述三组的4年生存率分别为46.3%、40.0%、53.8%。临床分析表明,以中西医结合组的疗效为佳。