全文获取类型
收费全文 | 18719篇 |
免费 | 1440篇 |
国内免费 | 464篇 |
专业分类
耳鼻咽喉 | 197篇 |
儿科学 | 161篇 |
妇产科学 | 221篇 |
基础医学 | 2000篇 |
口腔科学 | 627篇 |
临床医学 | 1313篇 |
内科学 | 1950篇 |
皮肤病学 | 338篇 |
神经病学 | 541篇 |
特种医学 | 1269篇 |
外国民族医学 | 2篇 |
外科学 | 6668篇 |
综合类 | 1886篇 |
现状与发展 | 2篇 |
预防医学 | 605篇 |
眼科学 | 180篇 |
药学 | 955篇 |
21篇 | |
中国医学 | 315篇 |
肿瘤学 | 1372篇 |
出版年
2024年 | 95篇 |
2023年 | 548篇 |
2022年 | 825篇 |
2021年 | 1065篇 |
2020年 | 1028篇 |
2019年 | 861篇 |
2018年 | 731篇 |
2017年 | 602篇 |
2016年 | 607篇 |
2015年 | 718篇 |
2014年 | 1306篇 |
2013年 | 1371篇 |
2012年 | 1074篇 |
2011年 | 1193篇 |
2010年 | 883篇 |
2009年 | 938篇 |
2008年 | 936篇 |
2007年 | 856篇 |
2006年 | 713篇 |
2005年 | 646篇 |
2004年 | 552篇 |
2003年 | 471篇 |
2002年 | 355篇 |
2001年 | 303篇 |
2000年 | 264篇 |
1999年 | 242篇 |
1998年 | 213篇 |
1997年 | 174篇 |
1996年 | 144篇 |
1995年 | 127篇 |
1994年 | 90篇 |
1993年 | 83篇 |
1992年 | 60篇 |
1991年 | 66篇 |
1990年 | 66篇 |
1989年 | 39篇 |
1988年 | 50篇 |
1987年 | 48篇 |
1986年 | 32篇 |
1985年 | 47篇 |
1984年 | 41篇 |
1983年 | 20篇 |
1982年 | 38篇 |
1981年 | 30篇 |
1980年 | 26篇 |
1979年 | 10篇 |
1978年 | 19篇 |
1977年 | 6篇 |
1976年 | 6篇 |
1968年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
Arthroscopic all-inside repair techniques of lateral meniscus anterior horn tear: a technical note 总被引:1,自引:0,他引:1
Choon Key Lee Jeung Tak Suh Chong Il Yoo Hyung Lae Cho 《Knee surgery, sports traumatology, arthroscopy》2007,15(11):1335-1339
Although the conventional outside-in technique is especially useful for repairing tears in the anterior portion of the meniscus,
it has a disadvantage of making an additional 1–2 cm sized skin incision and tying knots subcutaneously over the capsule.
Therefore we devised two all-inside repair techniques of lateral meniscus anterior horn tear according to the site of meniscal
tear, meniscosynovial junction or red–red zone. Because these techniques are modified methods of the outside-in meniscal repair
using a spinal needle, they are as simple as conventional outside-in technique. In addition they have advantages of vertical
mattress suture, which is an important characteristic of the all-inside repair, and no additional incision. We recommend these
techniques as an alternative method for repairing an anterior horn tear of the lateral meniscus. 相似文献
82.
目的 探讨感觉神经肽P物质(SP)对离体培养的肉芽组织成纤维细胞表皮生长因子(EGF)表达的调控作用及特点。方法 采用甲醛注射的方法造成Wistar大鼠局部无菌性炎性反应,提取肉芽组织进行成纤维细胞原代培养;采用逆转录—聚合酶链反应(RT—PCR)方法检测SP对肉芽组织成纤维细胞EGF基因表达的调控作用,观察时间及剂量—效应关系;采用Western-blotting方法检测EGF蛋白表达情况,观察时间及剂量—效应关系。结果 10^-7mol/L SP可诱导成纤维细胞EGF mRNA的表达,在作用后6h与对照组比,差异有显著性(P<0.01);SP在10^-8-10^-6mol/L范围内可以显著促进成纤维细胞EGF mRNA表达,在10^-7mol/L达到峰值,10^-5mol/L时与对照组差异无显著性(P>0.05)。10^-7mol/L SP作用12h后可检测到EGF蛋白明显表达增强(P<0.01),24h达高峰,48h后逐渐有所回落。SP在在10^-8--10^-5mol/L范围可诱导EGF蛋白的表达,均在10^-7mol/L剂量点达到峰值(P<0.01)。结论 SP可诱导肉芽组织成纤维细胞EGF基因和蛋白的表达,且呈现出一定的时间和剂量特点,在SP调控创伤愈合的作用中具有重要意义。 相似文献
83.
Regional gene therapy for full-thickness articular cartilage lesions using naked DNA with a collagen matrix. 总被引:3,自引:0,他引:3
Paul E Di Cesare Sally R Frenkel Cathy S Carlson Carrie Fang Chuanju Liu 《Journal of orthopaedic research》2006,24(5):1118-1127
A novel gene therapy approach for treating damaged cartilage is proposed that involves placing endotoxin-free cDNA containing the gene for bone morphogenetic protein-2 (BMP-2) in type I collagen sponges and then transferring the naked plasmid DNA construct to the injury site. A full-thickness cartilaginous defect in rabbits implanted with plasmid containing a marker gene (beta-galactosidase) showed expressed protein as detected by immunostaining. At 1 week postimplantation, mesenchymal cells subjacent to the defect had incorporated the implanted naked plasmid DNA and, once transfected, served as local bioreactors, transiently producing the gene product. Plasmids containing the gene for BMP-2 implanted in collagen sponges in cartilage lesions stimulated hyalinelike articular cartilage repair at 12 weeks postimplantation, nearly equivalent in quality to that induced by collagen sponges with recombinant BMP-2 protein. Our approach circumvents the risks of inflammation and immunogenic response associated with the use of viral vectors. Naked plasmid DNA as a vehicle for transferring therapeutic genes has been shown to be effective in a therapeutic model within rabbit articular cartilage and appears to be safe and cost effective. 相似文献
84.
85.
86.
Inflammation and the Aging Process: Devil or Angel 总被引:1,自引:0,他引:1
Inflammation is often viewed as a pathologic mechanism leading to tissue damage and interference with function, such as the process of chronic tissue scarring or fibrosis. However, it is important to note that inflammation is a crucial component of normal tissue repair as well as being fundamental to the body's defense against infection. Considering inflammation as a "causative agent in aging" belies the underlying mechanisms whereby the acute inflammatory response is necessary for survival, and efforts to reduce and control the inflammatory response leave the host susceptible to infectious agents and improper healing. Chronic inflammation inevitably has initiating mechanisms that include immune, autoimmune, and metabolic pathways, leading to the activation and presence of the host-protective response. It is more appropriate to target the underlying initiating conditions than the inflammatory process that ensues and treat the basic mechanisms of disease rather than interfere in a very important protective mechanism of the host. 相似文献
87.
Kamran Sardari Ehsan Galedar Kakhki Mehrdad Mohri 《Comparative clinical pathology》2007,16(3):197-200
Ten bulls (age 7 months, weight 302 ± 15 kg) were used in this study. After sterile preparation of skin, a full thickness
wound (20 × 20 mm) was created in each bull. The bulls were randomly assigned into two groups: group 1 received 6 ml Theranekron
subcutaneously and group 2 penicillin banzatine 10,000 IU/kg IM. These doses were repeated 6 days after initial wounding.
At days 0, 3, 6, 10 and 14, digital photographs were taken from the wounds to calculate wound contraction and epithelialization
using geometry. Chi-square test was performed for statistical analysis using SPSS 9 for Windows. There was no significant
differences in wound contraction between trial groups (P > 0.05) but a statistical difference was seen in epithelialization between groups (P < 0.05). Epithelialization is one of the most important factors in wound healing. According to the results of the present
study, Theranekron can significantly stimulate epithelialization in full thickness wounds in cows during the first 14 days
of healing. 相似文献
88.
Dr. Flemming Moesgaard M.D. Mogens Lykkegaard Nielsen M.D. Ph.D. Allan Hjortrup M.D. Peter Kjersgaard M.D. Carsten Sørensen M.D. Peter Nørgaard Larsen M.D. Steen Hoffmann M.D. 《Diseases of the colon and rectum》1989,32(1):36-38
One hundred ninety patients with peritonitis at the time of abdominal surgery were allocated at random to systemic antibiotic
treatment alone or systemic antibiotic treatment combined with topical application of antibiotics in the wound at the time
of wound closure. The overall wound infection rate was 17 percent without significant difference between the two treatment
groups (P>0.80). 相似文献
89.
Parapubic hernia: case report and review of the literature 总被引:1,自引:0,他引:1
Parapubic hernia is considered rare, with 18 hernias described in five articles published since 1971. The hernia results
from iatrogenically or traumatically detached rectus abdominis muscles at the pubic bone and presents a therapeutic challenge
because there is no strong aponeurotic anchoring structure in the defect's caudal aspect. We describe a patient with a large
parapubic hernia repaired by a combined preperitoneal and onlay prosthetic method. This report adds another dimension to the
prosthetic repair options in parapubic hernias and illustrates the effectiveness of the tension-free repair principle in their
definitive management.
Electronic Publication 相似文献
90.
Stephen S. Burkhart MD 《Operative Techniques in Sports Medicine》1997,5(4):204-214
Arthroscopic repair of rotator cuff tears is now possible. By using the biomechanical principles of margin convergenceand the balance of force couples, even large cuff defects can be repaired. Suture anchors are particularly suitable for arthroscopic repairs, and a corkscrew anchor design lends itself to a trans-tendon approach 相似文献