全文获取类型
收费全文 | 2601篇 |
免费 | 87篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 83篇 |
妇产科学 | 40篇 |
基础医学 | 142篇 |
口腔科学 | 47篇 |
临床医学 | 433篇 |
内科学 | 394篇 |
皮肤病学 | 24篇 |
神经病学 | 114篇 |
特种医学 | 61篇 |
外科学 | 205篇 |
综合类 | 103篇 |
预防医学 | 637篇 |
眼科学 | 17篇 |
药学 | 263篇 |
1篇 | |
中国医学 | 56篇 |
肿瘤学 | 81篇 |
出版年
2024年 | 6篇 |
2023年 | 138篇 |
2022年 | 166篇 |
2021年 | 207篇 |
2020年 | 184篇 |
2019年 | 204篇 |
2018年 | 167篇 |
2017年 | 115篇 |
2016年 | 65篇 |
2015年 | 72篇 |
2014年 | 167篇 |
2013年 | 198篇 |
2012年 | 142篇 |
2011年 | 155篇 |
2010年 | 106篇 |
2009年 | 107篇 |
2008年 | 96篇 |
2007年 | 97篇 |
2006年 | 53篇 |
2005年 | 40篇 |
2004年 | 36篇 |
2003年 | 24篇 |
2002年 | 22篇 |
2001年 | 14篇 |
2000年 | 12篇 |
1999年 | 14篇 |
1998年 | 10篇 |
1997年 | 11篇 |
1996年 | 8篇 |
1995年 | 3篇 |
1994年 | 5篇 |
1993年 | 3篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 2篇 |
1987年 | 2篇 |
1985年 | 9篇 |
1984年 | 5篇 |
1983年 | 1篇 |
1982年 | 6篇 |
1981年 | 4篇 |
1980年 | 5篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 5篇 |
1975年 | 1篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1970年 | 1篇 |
排序方式: 共有2711条查询结果,搜索用时 78 毫秒
111.
任长松 《临床合理用药杂志》2014,(12):24-25
目的:探讨抗生素分级管理制度实施后的应用效果。方法对本院2O11年1-6月即抗生素分级管理制度实施前和2O12年1-6月即抗生素分级管理制度实施后本院住院、门诊抗生素的使用率、Ⅰ类切口手术抗生素预防使用率进行分析,观察变化情况。结果实行抗生素分级管理后,住院、门诊抗生素的使用频率及Ⅰ类切口手术抗生素药物的预防使用率均比前一年降低,差异有统计学意义( P 〈 O. O5)。结论抗生素分级管理应用于医院用药系统中对指导临床合理使用抗生素具有重要的指导意义,值得临床上进行普遍的推广使用。 相似文献
112.
Catton Howard 《International nursing review》2019,66(4):453-455
The World Health Organization has designated 2020 as the Year of the Nurse and Midwife. With a predicted shortfall of more than nine million nurses and midwives by 2030, the World Health Organization has recognized the urgency of tackling the approaching workforce issues head on. The activities planned should provide a once in a generation opportunity to promote the nursing profession and address crucial issues, such as recruitment and retention, professional development and pay and conditions. The International Council of Nurses is working closely with its National Nursing Associations around the world and other key nursing and health organizations, to create a long‐lasting legacy that will raise the profile of the profession with the public, boost its professional status, and make it sustainable in the future. 相似文献
113.
Howard Catton 《International nursing review》2019,66(3):299-301
This year’s International Council of Nurses Congress in Singapore was an opportunity for nurses from around the world to discuss and shape policy and practice around the world. The World Health Organization recognises ICN’s unique ability to influence its policies, represent nursing and help with the challenges that lie ahead, including a potential shortfall of nine million nurses by 2030. All nurses can get involved in efforts to raise the profile of the profession and attract a new generation who will continue to maintain the high standards expected of registered nurses for decades to come. 相似文献
114.
Stephanie Stewart Brett Scholz Sarah Gordon Brenda Happell 《International journal of mental health nursing》2019,28(1):339-350
Contemporary mental health policies call for increased involvement of consumers in leadership across mental health service design, delivery, and evaluation. However, consumer leadership is not currently well understood within academia or in mental health services themselves. This study investigates how consumer leadership is currently conceptualized by stakeholders at the service delivery level. To this end, semistructured interviews were conducted with 14 mental health organization members identifying as consumer leaders, colleagues supporting consumer leaders, or organization executives. Interview data were analysed using an inductive thematic analysis to develop a broad understanding of participants’ perceptions of consumer leadership. Findings indicate constructions of consumer leadership within mental health organizations can be understood in relation to four themes: consumer leadership roles, requirements, purpose, and process. Inconsistencies across participants’ perceptions of consumer leadership were identified as constituting barriers to its development, highlighting the need to better clarify the nature of consumer leadership. 相似文献
115.
Michihiro Hide Takamasa Suzuki Ayaka Tanaka Hiroshi Aoki 《Allergology international》2019,68(1):59-67
Background
Rupatadine, a novel nonsedating second-generation H1-antihistamine with antiplatelet-activating factor activity, has been used in the treatment of allergic rhinitis and urticaria in European countries since 2003. However, its efficacy and safety in Japanese patients with chronic spontaneous urticaria (CSU) are unknown.Methods
We conducted a prospective, multicenter, randomized, placebo-controlled, double-blind study in adolescent and adult CSU outpatients aged 12 to < 65 years (JAPIC-CTI No. 152786). Overall, 94, 91, and 92 eligible patients orally received placebo, rupatadine 10 mg, and 20 mg once daily for 2 weeks, respectively. The primary endpoint was change from baseline to the second week of treatment in total pruritus score (TPS, sum of daytime and nighttime pruritus scores).Results
The results yielded a least squares mean TPS difference of ?1.956 between rupatadine 10 mg versus placebo, and ?2.121 between rupatadine 20 mg versus placebo (analysis of covariance, both P < 0.001). The incidence of adverse events was 8.5% for placebo, 20.9% for rupatadine 10 mg, and 17.4% for rupatadine 20 mg. Somnolence was the only adverse drug reaction to rupatadine reported in 2 or more subjects. No serious or clinically significant adverse events were observed.Conclusions
The primary and secondary efficacy endpoints consistently favored rupatadine 10 and 20 mg doses over the placebo. No noteworthy dose-related increase in the incidence of adverse drug reactions was observed. Rupatadine is safe and effective at a dose of 10 mg once daily, and can be safely increased to 20 mg once daily, as necessary. 相似文献116.
Takao Fujisawa Terufumi Shimoda Keisuke Masuyama Kimihiro Okubo Kohei Honda Mitsuhiro Okano Toshio Katsunuma Atsuo Urisu Yasuto Kondo Hiroshi Odajima Kazuyuki Kurihara Makoto Nagata Masami Taniguchi Shoichiro Taniuchi Satoru Doi Tomoshige Matsumoto Shoji Hashimoto Akihiko Tanaka Hideki Ozaki 《Allergology international》2018,67(3):347-356
Background
To evaluate the long-term safety of subcutaneous immunotherapy with TO-204, a standardized house dust mite (HDM) allergen extracts, we conducted a multicenter, open label clinical trial.Methods
Japanese patients aged 5–65 years were eligible for the study, if they had HDM-induced allergic rhinitis (AR), allergic bronchial asthma (BA), or both. TO-204 was administered in a dose titration scheme, and the maintenance dose was determined according to the predefined criteria. The treatment period was 52 weeks, and patients who were willing to continue the treatment received TO-204 beyond 52 weeks. This clinical trial is registered at the Japan Pharmaceutical Information Center (Japic CTI-121900).Results
Between July 2012 and May 2015, 44 patients (28 with AR and 16 with allergic BA) were enrolled into the study. All patients were included in the analysis. The duration of treatment ranged from 23 to 142 weeks and the median maintenance dose was 200 Japanese allergy units (JAU). Adverse events occurred in 22 patients (50%). The most common adverse event was local reactions related to the injection sites. Four patients experienced anaphylactic reactions when they were treated with the dose of 500 JAU. Two patients experienced anaphylactic shock with the doses of 1000 JAU at onset. These 6 patients could continue the study with dose reduction.Conclusions
Safety profile of TO-204 was acceptable in Japanese patients with HDM-induced AR or allergic BA. Higher doses should be administered carefully, because the risk of anaphylaxis increased at doses of 500 or 1000 JAU. 相似文献117.
Sherif Emil Geoffrey Blair Jacob C. Langer Grant Miller Ann Aspirot Guy Brisseau B.J. Hancock 《Journal of pediatric surgery》2014
Background
There is significant lack of information regarding the Canadian pediatric surgery workforce.Methods
An IRB-approved survey aimed at assessing workforce issues was administered to pediatric surgeons and pediatric surgery chiefs in Canada in 2012.Results
The survey was completed by 98% of practicing surgeons and 13 of the 18 division chiefs. Only 6% of surgeons are older than 60 years, and only a fifth anticipate retirement over the next decade. The workforce is stable, with 82% of surgeons unlikely to change current positions. Surgical volume showed essentially no growth during the 5-year period 2006–2010. The majority of surgeons felt they were performing the right number or too few cases and anticipated minimal or no future growth in their individual practices or that of their group. Based on anticipated vacancies, the best estimate is a need for 20 new pediatric surgeons over the next decade. This need is significantly surpassed by the current output from the Canadian training programs.Conclusions
The Canadian pediatric surgery workforce is currently saturated. The mismatch between the number of graduating trainees and the available positions over the next decade has significant repercussions for current surgery and pediatric surgery residents wishing to practice in Canada. 相似文献118.
119.
Recent global debates on the research and development (R&D) of health technologies, such as drugs, diagnostics and vaccines, can be seen as a microcosm of discussions on the role of the World Health Organization (WHO) in the global health system more broadly. The global R&D system has come under heightened scrutiny with the publication of a 2012 report by the WHO Consultative Expert Working Group on Research and Development (CEWG), which made a number of recommendations to more equitably meet global health needs. The CEWG report followed a decade-long process of debate at the WHO on the weaknesses of the global R&D system, which include problems of affordability, limited research where market returns are small or uncertain (such as the ‘neglected diseases’ that predominantly affect the world's poorest), inefficient overlap of research efforts, and overuse of medicines such as antibiotics. The CEWG report called on WHO Member States to develop a global framework to improve monitoring, coordination and financing of R&D efforts through the establishment of a Global Health R&D Observatory and the negotiation of a binding treaty on R&D. While the treaty option has been put on the back-burner for several years, Member States nevertheless agreed at the 2013 World Health Assembly (WHA) on concrete steps towards a global framework. Progress at the 2013 WHA reaffirmed the central role of WHO as a convener, and the WHA's decision to create the Observatory within the WHO Secretariat underscored the organization's role as a source of strategic knowledge in the global health system. However, despite WHO's constitutional mandate as the ‘directing and coordinating authority on international health work’, in reality it faces major challenges in coordinating autonomous R&D actors such as states, firms and foundations in the global system. Strengthening its ability to do so requires, at a minimum, reforming its financing arrangements to provide it with a greater degree of independence from its largest donors. In addition, WHO may seem to be the natural arena for negotiating a binding R&D treaty, but negotiating new global agreements in other arenas such as the WTO, WIPO, or plurilateral fora offer the possibility of more enforceable and stronger public health norms. Nevertheless, no single arena in the existing system of global governance is perfectly suitable for the negotiation of progressive, inclusive, binding, enforceable, global health rules. While tradeoffs are inherent in the choice of any particular arena, leadership from either the multilateral institutions or influential governments can make a key difference in how beneficial any R&D treaty may be for health. In the coming years, global R&D debates will remain a critical issue to watch. The evolution of the global R&D system will be a harbinger not only of WHO's place in a rapidly-changing global health system, but also of our collective capacity to strengthen institutions of global governance for health. 相似文献
120.
Giovana Dorneles Callegaro Higashi Alacoque Lorenzini Erdmann 《Revista latino-americana de enfermagem》2014,22(2):269-276