国际生物医学大数据研究可视化分析

以WOS数据库为数据源,全面采集生物医学大数据相关文献,以CiteSpace和VOSViewer软件绘制科学知识图谱,对当前生物医学大数据研究力量、研究热点及演进趋势进行分析。     

我国军事医学发展态势文献计量分析

运用文献计量和可视化研究方法,以中国知网数据库期刊为数据来源,对我国军事医学相关文献从年度发文趋势、主要研究机构、研究机构合作网络、关键词、重点研究领域等方面进行深入分析,提出应加强军民融合、注重技术性和前沿性研究等建议。     

基于共词分析的循证心血管可视化研究

目的通过关键词共现分析和作者共现分析的方式,研究国内外循证心血管领域的研究热点、学科分支和发展趋势。方法通过检索中国生物医学数据库和Medline数据库,分别收集相关研究文献,并提取关键词词频、作者发文数和核心研究单位,对核心关键词和核心发文作者建立共现矩阵,使用Ucinet绘制可视化网络图。结果成功得到核心关键词和核心作者可视化网络。中文可视化网络包括循证医学、治疗和护理3个方面,英文可视化网络包括evidence-based medicine、therapy和treatment outcome 3个方面。而在作者合作可视化网络中,国内作者合作关系较为松散,合作团体较小,国外作者合作关系较为紧密,合作团体较大。国内核心研究机构分布于循证研究重点高校,国外则以发达国家为主。结论国内循证心血管研究领域总体发展趋势较好,但较国外相比仍存在一些不足,需要进一步加强重点研究,调整研究规划。     

近5年国内外图书情报学发展现状与研究热点

目的：梳理国内外图书情报学领域的发展现状与研究热点，为图书情报学领域的深入研究提供参考。方法：以Web of Science及《中文核心期刊要目总览》与“中文社会科学引文牵引”（CSSCI）收录的高影响力图书情报学期刊在2016-2020年所刊载的论文为数据源，通过可视化软件CiteSpace对作者、国家、机构、关键词等进行分析。结果：国内外均没有形成大范围相互联系的作者合作网络。西方发达国家在该领域的研究优势比较明显，形成了以美国为中心的世界范围内的合作网络。国外研究机构主要集中在高等院校和医院，国内集中在高等院校和科研院所。国外文献计量学研究、知识管理研究和医学信息学研究等越来越受到学者们的关注，国内研究仍处于探索阶段，与国外还存在较大差距。结论：未来应该加强该领域学者和机构间的交流与合作，丰富研究主题，提升我国在该领域的学术影响力。     

国内外ICU获得性衰弱干预研究的文献计量学与可视化分析

目的 通过梳理目前国内外有关ICU获得性衰弱干预的研究现状、热点与趋势,为后续该方面的研究提供思路。方法 检索中国知网及PubMed中ICU获得性衰弱干预的相关文献,运用CiteSpace、BICOMB软件对其进行数据的提取与分析。结果 纳入有效文献中文83篇、英文164篇；国内ICU获得性衰弱干预研究的数量呈大幅上升趋势,国外较平稳；国内热点干预措施主要为早期活动、中医穴位刺激、电刺激、胰岛素疗法、康复,国外主要为物理疗法、神经肌肉电刺激、康复。结论 英美两国于该研究领域中占主导地位；国内华东地区的研究力量最强。建议国内在该领域增强多中心合作意识、探索国外的类似干预在中国人群中的作用、增加不同干预之间的对比分析、基于循证构建干预策略、在继续探索中医干预对ICU-AW的影响的同时也要深剖其机制。     

基于科学知识图谱的针灸专利计量可视化研究＊

目的 运用专利计量可视化方法探索针灸技术热点及发展趋势，为针灸技术领域创新研究提供参考，提高针灸技术临床应用，加快针灸技术发展。方法 利用文献计量软件Citespace 5.5.R2对从建库以来至2020年收录在德温特专利数据库（Derwent Innovations Index，DII）的27177篇针灸相关专利文献进行总结、分析，并以可视化图谱的形式展现出针灸专利的申请量、学科分布，专利权人、发明人合作网络，专利技术热点、发展趋势等指标特征。结果 针灸专利申请量呈现逐年上升趋势；学科涉仪器、内科医学、工程学、化学、药物药剂学等方面；中国为发明人和专利权人最多的国家，成都中医药大学、湖南中医药大学、上海中医药大学、河南中医药大学是针灸技术创新的主要创新机构；热点技术领域集中在针灸治疗仪器设备创新、中医经络理论指导下的养生保健设备创新；技术创新的趋势是诊疗一体化、数字化、智能化。结论 运用专利计量可视化方法发现目前针灸专利技术发展较快，探测到目前针灸技术领域的热点及趋势，可为针灸技术创新研究提供参考。     

Phase-amplitude coupling of ripple activities during seizure evolution with theta phase

ObjectiveHigh-frequency activities (HFAs) and phase-amplitude coupling (PAC) are key neurophysiological biomarkers for studying human epilepsy. We aimed to clarify and visualize how HFAs are modulated by the phase of low-frequency bands during seizures.MethodsWe used intracranial electrodes to record seizures of focal epilepsy (12 focal-to-bilateral tonic-clonic seizures and three focal-aware seizures in seven patients). The synchronization index, representing PAC, was used to analyze the coupling between the amplitude of ripples (80–250 Hz) and the phase of lower frequencies. We created a video in which the intracranial electrode contacts were scaled linearly to the power changes of ripple.ResultsThe main low frequency band modulating ictal-ripple activities was the θ band (4–8 Hz), and after completion of ictal-ripple burst, δ (1–4 Hz)-ripple PAC occurred. The ripple power increased simultaneously with rhythmic fluctuations from the seizure onset zone, and spread to other regions.ConclusionsRipple activities during seizure evolution were modulated by the θ phase. The PAC phenomenon was visualized as rhythmic fluctuations.SignificanceRipple power associated with seizure evolution increased and spread with fluctuations. The θ oscillations related to the fluctuations might represent the common neurophysiological processing involved in seizure generation.     

Three-dimensional coronary angiography of the perfused rat heart

The purpose of this work was to visualize the whole three-dimensional coronary artery tree of the perfused beating rat heart using three-dimensional MRI. The spatial resolution amounts to 140 μm. Also, vessels having smaller diameters could be detected. Different strategies for the visualization of the three-dimensional coronary angiograms including maximum intensity projection, data thresholding, and segmentation, were shown. The coronary artery tree was best visualized by hysteresis threshold segmentation and subsequent surface reconstruction.     

Methods for spherical data analysis and visualization

A systematic analysis of the localization of objects in extra-personal space requires a three-dimensional method of documenting location. In auditory localization studies the location of a sound source is often reduced to a directional vector with constant magnitude with respect to the observer, data being plotted on a unit sphere with the observer at the origin. This is an attractive form of data representation as the relevant spherical statistical and graphical methods are well described. In this paper we collect together a set of spherical plotting and statistical procedures to visualize and summarize these data. We describe methods for visualizing auditory localization data without assuming that the principal components of the data are aligned with the coordinate system. As a means of comparing experimental techniques and having a common set of data for the verification of spherical statistics, the software (implemented in MATLAB) and database described in this paper have been placed in the public domain. Although originally intended for the visualization and summarization of auditory psychophysical data, these routines are sufficiently general to be applied in other situations involving spherical data.