基于网络药理学探析补中益气汤治疗变应性鼻炎的作用机制

目的：基于网络药理学探析补中益气汤治疗变应性鼻炎的作用机制。方法：通过中药系统药理学数据库与分析平台(TCMSP)筛选得到补中益气汤的化学成分和作用靶点,同时利用GeneCards数据库获得与变应性鼻炎治疗相关的靶基因,利用Cytoscape3.7.1软件将所获得数据进行“药物-成分-疾病-靶点”网络可视化模型构建,使用STRING数据库构建共有靶基因的蛋白质-蛋白质相互作用（ PPI）网络,最后采用R软件以P<0.05、Q<0.05进行关键靶基因本体（GO）富集分析和京都基因和基因组百科全书（KEGG） 功能富集分析。结果：筛选出补中益气汤有效活性成分172个,其治疗变应性鼻炎的机制可能与IL6、VEGFA、JUN、MMP9、MMP2等核心靶蛋白密切相关,推测其主要通过参与IL-17、TNF、HIF-1、Toll样受体、PI3K-AKT、核因子κB、MAPK、Th1和Th2细胞分化、JAK-STAT等信号通路干预调控变应性鼻炎。结论：本研究揭示了补中益气汤治疗变应性鼻炎多基因、多靶点、多通路的网络调节机制,从整体角度阐述了中医药有效的作用机制,为下一步实验研究提供分子层面的思路。     

The study of three-dimensional reconstruction of Chinese adult liver

Purpose  To build a three-dimensional (3D) visible model of human liver and provide visualization of precise anatomical structures for making plans for hepatic operations and obtain accurate simulation of liver on computer. Methods  Based on the Chinese Visible Human data set, the hepatic structures were precisely segmented by Photoshop software. Then the segmented structures were reconstructed in surface rendering method and the hepatic parenchyma and the other parts of upper abdomen were reconstructed with volume rendering method by using our software on personal computer. Results  A 3D model of human liver and its surrounding structures was built. The reconstructed structures can be displayed singly, in small groups or as a whole and can be continuously rotated in 3D space at different velocities. This model can help doctors to understand the spatial structure of the liver and its surrounding organs and also help surgeons to devise a reasonable surgical plan and reduce the risk of surgical malpractice. Conclusion  Combining volume-rendering reconstruction with surface rendering reconstruction can overcome some of the defects of both rendering reconstructions. The reconstructed liver and the main internal structures are realistic, which demonstrate the natural shape and exact position of the structures. They provide an accurate anatomical model for Chinese adult and also provide a basis for performing virtual hepatic operation.     

虚拟人的腰丛神经断层解剖学及可视化研究

目的观测“虚拟中国人”（virtual Chinese human,VCH）女性Ⅰ号、男性Ⅲ号腰丛神经连续横断面的走行,建立腰丛神经的可视化数字模型。方法应用“虚拟中国人”女性Ⅰ号（VCH—FⅠ）和男性Ⅲ号（VCH．Mm）数据集,在薄层断面图像上观察腰丛神经的构成及其与腰大肌和周围血管的关系,应用Amira3．1（WGS）软件对腰丛神经及其周围结构进行计算机三维重建并立体显示。结果在VCH-FⅠ和VCH—MⅢ的薄层断面图像上可以清楚地显示腰丛神经的主要结构,重建的数字化模型可准确地反映腰丛神经解剖学结构特点。结论VCH—FⅠ和VCH—MⅢ数据集能够提供完整精确的腰丛神经断面解剖,重建的数字化模型为腰丛神经损伤的影像诊断和外科治疗提供了良好的形态学依据。     

计算机辅助医学图像三维重建的算法分析

背景：基于三维重建的医学图像可视化技术具有广阔的应用前景，是目前研究的热点内容。 目的：为医学图像三维重建时算法的选择提供帮助。 方法：分析面绘制重置方法和体绘制重置方法的实现原理、实现复杂度、实时显示情况等方面。 结果与结论：在对重建方法分析的基础上，总结出面绘制和体绘制两种方法各自的优势和弱点，分析在不同情况下如何进行算法的选择。     

Three-dimensional ultrasound imaging

The objective of this article is to provide scientists, engineers and clinicians with an up-to–date overview on the current state of development in the area of three-dimensional ultrasound (3-DUS) and to serve as a reference for individuals who wish to learn more about 3-DUS imaging. The sections will review the state of the art with respect to 3-DUS imaging, methods of data acquisition, analysis and display approaches. Clinical sections summarize patient research study results to date with discussion of applications by organ system. The basic algorithms and approaches to visualization of 3-D and 4-D ultrasound data are reviewed, including issues related to interactivity and user interfaces. The implications of recent developments for future ultrasound imaging/visualization systems are considered. Ultimately, an improved understanding of ultrasound data offered by 3-DUS may make it easier for primary care physicians to understand complex patient anatomy. Tertiary care physicians specializing in ultrasound can further enhance the quality of patient care by using high-speed networks to review volume ultrasound data at specialization centers. Access to volume data and expertise at specialization centers affords more sophisticated analysis and review, further augmenting patient diagnosis and treatment.     

基本公共卫生服务文献计量分析

以CNKI为数据源,检索我国公共卫生服务项目相关文献,采用文献计量学方法从发文量、研究层次、作者机构、基金来源、研究热点、合作者等方面进行梳理及分析,将结果做可视化展示,初步揭示我国现阶段基本公共卫生服务研究现状及存在问题,以期为后续研究提供参考。     

交互式医学图像控制系统在正颌外科手术中的应用

目的 探讨交互式医学图像控制系统（MIMICS）在计算机辅助手术中的应用价值,为术前进行精确设计手术方案及达到术后良好效果提供真实可靠依据。方法 对2例正颌外科手术患者的头面部三维CT断层扫描图像,进行识别确定重建对象,对皮肤、皮下组织及骨组织采用灰度阈值法进行自动重建;采用MIMICS软件对获取的医学信息进行分层网格划分,完成建模。根据资深正颁外科医师制订的方案,在模型中完成手术的模拟和软组织形变的预测。结果 完成了包含皮肤、皮下组织和骨组织的患者头面部三维网格模型。模拟了正颌外科手术移动骨质过程,并且以动态动画形式演示,可从任意角度进行观察。实现了正颌外科手术术后软组织形变的可视化预测。结论 利用医学影像资料,采用MIMICS软件可实现人头面部复杂结构的三维重建和分层网格划分,以动态形式完成正颌外科手术的模拟和软组织形变预测。在计算机屏幕前制订手术方案进行医患交流,共同协商,提高了正颌外科手术安全性、精确性和矫治效果。     

超大规模医学图像并行虚拟可视化的仿真研究

在网格计算基础上,研究利用医院内部局域网和普通配置计算机,实现超大规模医学图像并行可视化的关键技术,包括系统硬件构成、软件框架、负载平衡以及虚拟现实可视化等问题。在普通计算机群上,编程实现大规模医学图像的最大密度投影重建算法,并在虚拟现实构造语言(virtual reality modeling language,VRML)基础上,设计人机交互控制面板,实现虚拟可视化操作。仿真结果表明,该方法较好地解决了运算速度和内存空间这两大难题,效果良好,实时性强,对医生诊断治疗具有很好的辅助作用。