术前玻璃体腔注射康柏西普联合25G+玻璃体切割术治疗增殖性糖尿病视网膜病变

目的：探讨术前玻璃体腔注射康柏西普联合25G+玻璃体切割术(PPV)治疗增殖性糖尿病视网膜(PDR)病变的疗效。

方法：回顾性分析。收集2019-01/2021-06我院收治的PDR患者154例176眼临床资料。根据治疗方法分为联合治疗组80例92眼采用术前玻璃体腔注射康柏西普联合25G+PPV治疗，对照组74例84眼仅采用25G+PPV治疗。比较两组患者治疗后临床疗效，手术前后血清脂肪因子\〖脂联素(APN)、视黄醇结合蛋白4(RBP4)\〗水平。

结果：术后1mo联合治疗组临床疗效优于对照组(P<0.05)。术后3mo，两组RBP4水平低于术前(P<0.05)，且联合治疗组术后低于对照组(P<0.05)； 两组血清APN显著高于术前(P<0.05)，联合治疗组高于对照组(P<0.05)。随访3mo，联合治疗组视网膜增殖、术后并发症发生率低于对照组(P<0.05)。

结论：术前玻璃体腔注射康柏西普联合25G+PPV有利于提高PDR治疗效果，降低并发症发生率，可能与调控脂肪因子的表达有关。     

5-氨基酮戊酸光动力疗法在扁平疣患者中的应用效果

探讨5-氨基酮戊酸光动力疗法在扁平疣患者中的应用效果。方法 选取我院皮肤科2020年 5月-2023年5月收治的扁平疣患者160例为研究对象，采用随机数字表法分为对照组和观察组，各80例。对 照组予以维A酸乳膏治疗，观察组予以5-氨基酮戊酸光动力疗法，比较两组临床疗效、满意度及不良反应 发生情况。结果 观察组治疗总有效率为96.25%，高于对照组的58.75%，差异有统计学意义（P ＜0.05）； 观察组治疗满意度为88.75%，高于对照组的48.75%，差异有统计学意义（P ＜0.05）；两组不良反应发生率 比较，差异无统计学意义（P＞0.05）。结论 5-氨基酮戊酸光动力疗法可提升扁平疣治疗效果，且患者对 治疗满意度较高，安全性良好。     

Topical garlic treatment for verruca plana triggers Koebner phenomenon: A case report

Background

Verruca plana is a benign proliferation of the skin caused by human papilloma virus (HPV) infection. Fresh garlic can serve as an alternative therapy, and it has shown considerable effectiveness as a topical treatment for verruca plana. However, topical garlic treatment for verruca plana triggered Koebner phenomenon (KP), which has not been previously reported.

Aim

The aim of our report is to explore the possible causes of this adverse reaction.

Method

We here describe a 20-year-old female patient who developed a beaded rash after garlic treatment for facial wart plana, known as autoinoculation or KP.

Results

Garlic may have caused damage to the surrounding normal skin through primary irritation or allergic reactions. Then, the HPV virus on the primary verruca plana took the opportunity to spread to the surrounding skin injured by garlic stimulation, triggering the KP.

Conclusion

When using garlic to treat verruca plana, the operator needs to precisely apply the mashed garlic to the warts, and this treatment is strictly prohibited for patients who are allergic to garlic. Avoid such adverse reactions.