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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
目的:了解近年来泌尿系细菌感染致病菌及耐药性,为合理应用抗生素,提供临床根据。方法:对泌尿系感染患者298株病原菌进行药物敏感试验。结果:大肠埃希菌仍是引发泌尿系感染的主要病原菌,占53%,其次是葡萄球菌属,占19.40%,肠杆菌属占10.06%,肠球菌属占4.70%等,各类菌属耐药情况。结论:临床医师必须关注本地病原菌分布及耐药情况,合理应用抗生素,减少耐药性播散。 相似文献
92.
93.
醋酸棉酚诱导膀胱癌T24细胞凋亡的研究 总被引:3,自引:0,他引:3
目的 研究棉酚对膀胱癌T2 4 细胞的抑制作用和诱导凋亡作用 ,探讨其作用机制。方法 将不同浓度的醋酸棉酚作用于人T2 4 膀胱癌细胞 ,利用MTT法检测其有效作用浓度、瑞氏染色、流式细胞仪 ,观察T2 4 细胞的凋亡情况。结果 MTT法测得其IC50 值为 12 6.3 μmol·L-1,浓度为 5 0~ 3 0 0 μmol·L-1的棉酚具有诱导T2 4 细胞凋亡的作用 ,随着药物作用时间的延长凋亡率增加。结论 棉酚抗癌作用机制之一是诱导人T2 4 膀胱癌细胞凋亡 相似文献
94.
G. M. Brieger M. Mongelli L. Y. Hin T. K. H. Chung 《International urogynecology journal》1997,8(4):191-195
The epidemiology of urinary dysfunction in a Chinese population living in Hong Kong was investigated. Fifteen hundred ethnic
Chinese women answered a telephone questionnaire including symptoms of urinary dysfunction, anthropometric measurements, obstetric
history and place of birth. The relative predictive value of these factors was analyzed using logistic regression. The prevalence
of urinary dysfunction was 13%. Ten percent reported stress incontinence, and 4% had urgency or urge incontinence. The strongest
predictor was place of birth, with women born in mainland China having the highest prevalence of pure stress incontinence
(OR 1.33, CI 1.1–1.6). For the symptoms of detrusor instability age was the strongest predictor, with women over 50 years
being at greater risk (OR 2.8, CI 1.6–5.0). Contrary to earlier beliefs, urinary dysfunction in Chinese women is as common
as in Caucasian women. Place of birth is the strongest predictor for pure stress incontinence, with women born in mainland
China being at greater risk. This suggests that environmental factors in early life have a differential effect on the development
of urinary incontinence.
EDITORIAL COMMENT: Taiwan Chinese women have a comparable prevalence of urinary dysfunction with Hong Kong Chinese women.
A survey representing a multistage sample of 82 678 women aged 18 years or older was conducted in the Taipei area from January
to June 1993. A total of 818 cases were interviewed by trained students. One hundred and eighty-nine (23.1%) of the respondents
reported having had some degree of incontinence in the preceding 12 months, 28 (3.4%) reporting regular incontinence. Most
presented with stress urinary incontinence, whereas urge incontinence and mixed incontinence were more commonly seen in the
elderly group (aged 60 years or older). The risk factors for urinary incontinence included age, number of vaginal deliveries
(>3), number of abortions (>2) and maternal history of incontinence. Voiding symptoms (irritative or obstructive) and constipation
were significantly more prevalent among respondents with incontinence than those without (P<0.001). This evidence also indicates that the long-held belief that Chinese women have a much lower prevalence of urinary
dysfunction than western women has all but ended. 相似文献
95.
Aman SHARMA Susheel KUMAR Ajay WANCHU A. K. MANDAL Surjit SINGH Pradeep BAMBERY 《International journal of rheumatic diseases》2007,10(2):153-155
Inflammatory myopathies like dermatomyositis are associated with increased incidence of malignancies. This association has been commonly reported with malignancies of ovaries, gastro‐intestinal tract, breast and non‐Hodgkin's lymphomas but occurrence of dermatomyositis with bladder cancer has been rarely reported. We report a patient with carcinoma bladder who developed dermatomyositis while being treated for the bladder cancer. 相似文献
96.
膀胱癌组织P-gp,GST-π和TOPO-Ⅱ表达评估灌注化疗 总被引:1,自引:0,他引:1
目的:探讨膀胱癌的多药耐药性(MDR),指导灌注化疗用药。方法:采用免疫组化法检测44例膀胱癌病理标本中P-糖蛋白(P-gp)、谷胱肽S转移酶(GST-π)和拓扑异构酶(TOPO—Ⅱ)的表达,评估肿瘤耐药谱。结果:①P-gp检测显示,54.5%的病例对阿毒索、丝裂毒索、长春新碱等抗生索类和生物碱类抗癌药高耐药。②GST-π检测显示仅34.1%的病例对顺铂、环磷酰胺等高耐药,而反有56.8%的病例对该类药无耐药或低度耐药。③TOPO-Ⅱ检测显示对阿霉索、柔红毒索、VP16等TOPO-Ⅱ抑制剂类抗癌药,仅13.6%的病例高度耐药,29.5%中度耐药。56.8%低度耐药。结论:检测膀胱癌MDR,了解多药耐药谱,可指导灌注化疗用药。 相似文献
97.
飞行员配穿两种囊式抗荷服在不同环境温度和代谢水平时的热应激 总被引:4,自引:0,他引:4
目的 探讨飞行员配穿囊式抗荷服在不同环境温度、不同代谢水平条件下的热应激 ,为评价囊式抗荷服的热负荷和制定相应的保障措施提供理论依据。方法 6名受试者分别配穿KH - 3抗荷服及配套装备和KH - 7抗荷服及配套装备 (以下分别简称为“KH - 3”和“KH -7”) ,以不同代谢水平暴露于 2 0℃、2 5℃和 35℃环境。每次试验 70min。测量了受试者配穿KH- 3和KH - 7时的卫生学参数、皮肤温度、直肠温度、心率等 ,并以综合热应激指数 (CIHS)评定了热应激防护等级。结果 KH - 3和KH - 7的各项卫生学参数 (clo值、im、im/IJ)均无显著差别。KH - 3对照Ⅲ组和KH - 7对照Ⅳ组 (2 5℃ ,1178~ 132 5kJ·h- 115min ,36 8kJ·h- 15 5min)的CIHS均未超过生理安全限的 6 0 % (分别为 3.5 4和 3.4 6 ,属轻度热应激 ) ;KH - 3高代谢组和KH- 7高代谢组 (2 0℃ ,84 6~ 10 30kJ·h- 170min)的CIHS在生理安全限的 6 0 %~ 95 %之间 (分别为4 .2 4和 4 .6 0 ,属中度热应激 ) ;KH - 3高温组和KH - 7高温组 (35℃ ,1178~ 132 5kJ·h- 115min ,36 8kJ·h- 15 5min)的CIHS却超过生理安全限的 95 % (分别为 7.31和 7.87,属重度热应激 )。结论 受试者配穿KH - 3与KH - 7时的各项卫生学参数、热应激等均无显著差别 ,但配穿后者比 相似文献
98.
目的:明确辣椒素对正常大鼠和慢性脊髓损伤(SCI)大鼠排尿功能的影响和作用的可能机制。方法:建立SCI的动物模型,实验大鼠和正常大鼠分别全身给药或膀胱内灌注辣椒素,记录膀胱内压力变化图(CMG)和尿道外括约肌肌电图(EUS-EMG)的改变。结果:正常大鼠辣椒素全身用药后出现非排尿性膀胱收缩,排尿效率下降,但排尿压不受影响。膀胱内灌注辣椒素亦会导致排尿效率降低而不影响排尿压。SCI大鼠全身用药后非排尿性膀胱收缩消失,残余尿量减少,排尿压下降,但排尿效率提高,膀胱内用药则可完全阻断排尿反射。结论:对辣椒素敏感的膀胱感觉传入神经参与正常大鼠和SCI大鼠的排尿反射。对正常大鼠起稳定膀胱逼尿肌的作用,而对SCI大鼠则是引起膀胱灌注时非排尿性收缩的原因,因此,阻滞感觉传入神经纤维是治疗SCI后膀胱高反射的有效方法。 相似文献
99.
G. D'Agostino M. C. Chiari E. Grana 《Naunyn-Schmiedeberg's archives of pharmacology》1989,340(1):76-81
Summary The inhibitory effects of some muscarinic agonists on tritiated acetylcholine release evoked by field stimulation were investigated in the rat urinary bladder strip. The acetylcholine stores of the preparation were labelled with 3H-choline. Electrical field stimulation caused an outflow of tritium, reflecting the release of 3H-acetylcholine. The release of 3H-acetylcholine was decreased in a concentration-dependent manner by all the agonists tested: oxotremorine, muscarone, muscarine, carbachol and methylfurtrethonium. On the contrary, only muscarine and muscarone enhanced the basal efflux of tritium in a concentration-dependent fashion. Concentration-response curves were determined both at 2 Hz and at 1 Hz by using intermittent administration of the drugs. Maximal depression in release (by 78 – 82%) was observed in experiments at 1 Hz. A similar inhibition was obtained at 2 Hz frequency only when a low concentration of calcium (0.6 mM) in the medium was used. Oxotremorine was the most potent among the tested compounds with the same intrinsic activity as the other drugs. In contrast to the other agonists investigated, oxotremorine showed in about 10-fold greater potency at pre- than at postjunctional muscarine receptors in the rat urinary bladder. This difference might depend either on heterogeneity of muscarine receptors or on different mechanism(s) relating to the transducing properties of receptors at the pre- and postjunctional level. A comparison between the relative prejunctional potencies in the rat urinary bladder and in the guinea pig myenteric plexus (data from the literature) suggests that prejunctional muscarine receptors are similar in these tissues. Furthermore, the findings obtained with a low concentration of calcium in the medium may support the view that intraneuronal availability of calcium plays a significant role in modulating the prejunctional negative feed-back mechanism in the rat urinary bladder.Send offprint requests to Dr. G. D'Agostino at the above address 相似文献
100.
Pat D. O'Donnell 《Neurourology and urodynamics》1989,8(5):505-511
Urinary incontinence is a serious management problem among elderly patients. The care and management of chronic care patients is more difficult in those having urinary incontinence. The level of care required is dependent on both the continence and incontinence behavior of the patient. The continence behavior in this study is presented as the time interval between episodes of involuntary urine loss. The continence interval in elderly inpatient men having severe incontinence was found to be significantly longer in patients having a larger measured cystometric bladder capacity as well as in patients having greater independence in activities of daily living. Significant variability in the continence interval was measured for each patient over a wide range of continence intervals and resulted in an irregular pattern of time between episodes of incontinence. The irregular continence intervals suggest an instability of the central nervous system sensory-motor regulatory mechanism of bladder control in the elderly. 相似文献