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991.
Effect of some new thioglycosides on endotoxin-induced disseminated intravascular coagulation in rabbits 总被引:1,自引:0,他引:1
Disseminated intravascular coagulation (DIC) is a systemic thrombohemorrhagic disorder seen in association with many clinical situations, e.g. sepsis, malignancy, obstetrical complications and intravascular hemolysis. In our model, disseminated intravascular coagulation was induced in rabbits by two consecutive intravenous bolus injections of endotoxin from Escherichia coli, 80 and 40 μg/kg. The control group was treated with 0.9% saline. The activity of thioglycosides was compared to unfractionated heparin (UFH) and efegatran with and without administration of endotoxin. Drugs were administered in the following doses: heparin 50 and 100 IU/kg/h i.v. infusion; efegatran 0.25 and 0.5 mg/kg/h i.v. infusion; GYKI 39521 (RGH-1875) as well as GYKI 39541 (RGH-1962) 12.5 and 25 mg/kg per os. Thioglycosides did not modify coagulation parameters in this model [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT)] as compared with endotoxin/vehicle group. The changes in TFPI level after administration of thioglycosides and heparin were similar in the mentioned model to those without endotoxin. Endotoxin-induced changes of leukocyte count were not affected by GYKI 39521 and GYKI 39541 treatment in our model. Diminution of fibrinogen level and platelet count was prevented by GYKI 39521 and GYKI 39541. Fibrin degradation products and fibrinolysis were significantly decreased by GYKI 39521 and GYKI 39541. The thioglycosides may have a lower risk of bleeding in the treatment of disseminated intravascular coagulation than heparin. 相似文献
992.
Bajanowski T Fürst P Wilmers K Beike J Köhler H Brinkmann B 《International journal of legal medicine》2002,116(1):27-32
The concentrations of the most common dioxin and dibenzofuran congeners were measured in different tissues (e.g. liver, kidneys,
subcutaneous fatty tissue and spleen) from 27 infants who died suddenly and unexpectedly. The cases could be subdivided into
2 groups consisting of 15 infants who died in 1991/1992 and in 12 infants who died in 1996/1997. The autopsies were carried
out using a standardised protocol and additionally the parents were asked to supply details of the nutritional conditions.
The age of the mother and the birth order of the infants were also recorded. From the results obtained by correlating these
parameters with the dioxin concentrations three main factors could be established: 1) there was a significant decrease in
the total dioxin concentration in infant tissues from 1991/1992 to 1996/1997 indicating a decrease in the environmental dioxin
levels due to a decrease in dioxin emission, 2) the birth order was inversely and the duration of breast feeding directly
proportional to the dioxin concentrations thus showing that the mothers can decontaminate themselves by breast feeding and
3) an accumulation of specific dioxin congeners was observed in the liver tissue but the pathophysiological significance of
these observations is not yet fully understood. Because of the well-known beneficial effects of breast feeding and considering
the results of the present study, this type of infant nutrition can be recommended without any restrictions.
Received: 23 March 2001 / Accepted: 25 July 2001 相似文献
993.
994.
目的探讨金属蛋白酶组织抑制剂-1(TIMP-1)在进行性肌营养不良(PMD)发病中的作用。方法中国医科大学附属第一医院等单位于2002年4月至2003年3月,借助免疫组织化学、双免疫荧光标记和Western印迹分析的方法,检测Duchenne型肌营养不良(DMD)、Becker型肌营养不良(BMD)和先天性肌营养不良(CMD)患儿活检肌肉标本中TIMP-1的表达和细胞定位。结果免疫组织化学和双免疫荧光标记结果显示TIMP-1在正常肌肉的血管内皮细胞处表达;免疫组织化学和Western印迹分析均显示在PMD萎缩的肌肉中TIMP-1的表达明显增强;双免疫荧光标记进一步显示TIMP-1在再生肌肉纤维、巨噬细胞和巨噬细胞浸润的坏死纤维中明显表达,DMD和CMD肌肉中的肌内膜和肌束膜中某些激活的成纤维细胞也强烈表达TIMP-1。结论在PMD病变部位TIMP-1产生增多及其分布类型提示TIMP-1可能参与了PMD的发病。 相似文献
995.
996.
目的:运用组织芯片及常规病理切片检测活化的细胞毒性细胞在各型淋巴瘤中的表达分布情况,为临床治疗和判断预后提供依据。方法:运用免疫组化方法检测60份淋巴瘤标本制成的组织芯片中穿孔素、颗粒酶B的表达和分布情况,同时选择10份鼻自然杀伤细胞(NK)/T细胞淋巴瘤常规标本与组织芯片进行比较研究,10份淋巴组织反应性增生标本作为对照。结果:在60份淋巴瘤组织芯片中,发生在淋巴结内者48份,淋巴结外者12份。B细胞淋巴瘤42份,T细胞淋巴瘤16份(外周T细胞淋巴瘤10份、NK/T细胞淋巴瘤2份、T淋巴母细胞瘤2份及问变性大细胞淋巴瘤2份),2份霍奇金淋巴瘤。42份B细胞淋巴瘤的瘤细胞均不表达穿孔素和颗粒酶B。10份外周T细胞淋巴瘤中8份表达穿孔素,9份表达颗粒酶B,阳性表达细胞均为非肿瘤细胞。芯片中的2份和常规10份鼻NK/T细胞淋巴瘤中均见穿孔素和颗粒酶B过度表达。T、B细胞淋巴瘤与NK/T细胞淋巴瘤比较有显著性差异(P〈0.01)。结论:穿孔素和颗粒酶B是鉴定活化的细胞毒性细胞的免疫标志物,可作为NK/T细胞淋巴瘤的诊断性标志物;其在T细胞淋巴瘤中的表达反映了机体的抗肿瘤免疫反应机制。组织芯片技术具有高信息量、简捷、高效、实验误差小、重复性好等优点,可作为研究淋巴瘤的有用工具。 相似文献
997.
998.
999.
组织工程化神经研究进展 总被引:1,自引:0,他引:1
近年来,组织工程化周围神经研制工作取得了很大的进展。自体神经、同种异体神经和合成材料均可作为桥接神经缺损的神经导管,以化学萃取的同种异体神经及可降解的生物材料导管较为理想。同时,经培养和纯化后的雪旺细胞具有分泌多种神经营养因子活性,是提高修复神经损伤效果的关键。 相似文献
1000.