后纵隔巨大甲状腺乳头状癌一例

患者女,48岁。两年前无明显诱因出现轻微进食梗噎感,抬头时加重,未予治疗。近半年,梗噎感加重,并出现胸闷、咳嗽,痰中带血,遂来我院就诊。胸部CT显示:左后纵隔食管后方见一长条形低密度影,密度不均,其上方见环形斑     

Quantitative study of the morphological changes in the thyroid gland following IR laser radiation

The morphological changes produced in the thyroid glands of albino rats following radiation with a 904 nm infrared laser were studied. Two different levels of radiation were applied: 46.8 J/cm² and 140.4 J/cm². Evaluation of the changes in the densities of the epithelial, colloidal and follicular volumes and of the activation index revealed that the laser beam produced changes in the thyroid parenchyma. It was observed that there was a direct relationship between the severity of the lesion and the radiation energy applied.     

血清保存方法对促甲状腺激素结果的影响观察

目的 :观察血清保存方法对促甲状腺激素 (TSH)结果的影响。方法 :将甲状腺功能正常、异常患者共 10份血清 ,采用不同血清量、不同条件分组保存后测定 TSH。结果 :保存方法对 TSH结果有一定的影响。结论 :用于 TSH血清的保存量要多、要密封管口、低温保存。     

硫代葡萄糖甙对碘代谢和甲状腺的影响

猪饲喂８％～１６％英籽饼日粮，平均每日从日粮中摄入９１９．４２～１４１６．０２ｍｇ硫代葡萄糖甙。在连续饲喂１２０天后，其甲状腺肿大，甲状腺滤泡和甲状腺上皮细胞显著增生，细胞质内缺乏分泌颗粒和溶酶体，细胞顶端密集微绒毛；滤泡腔内胶质周边部具有大量吸收空泡，分泌功能旺盛。Ｔ＿４和Ｔ＿４／Ｔ＿３比值明显升高，甲状腺功能亢进。若日粮中增加给碘量和服用解毒剂，猪甲状腺的组织形态学和超微结构接近正常，Ｔ＿４和／Ｔ＿４／Ｔ＿３比值亦趋于正常。     

Ag—NOR计数在区分良恶性甲状腺病变中的意义

随机选择经长期随访证实的滤泡性甲状腺癌和腺瘤各10例,正常甲状腺组织5例作为对照。按Ploton的染色方法和Crocker推荐的计数方法分别计算三组每例各50个细胞的Ag-NOR嗜银颗粒平均数,再算出三组各自的AgNOR均数,经统计学检验三者有极显著性差异。可望成为甲状腺滤泡性肿瘤良恶鉴别的一项辅助指标。     

甲状腺滤泡性肿瘤Logistic判别分析及预后分析

本文对８５例滤泡性腺癌（ＦＣ）、６１例滤泡性腺瘤及２３例未定性滤泡性肿瘤的临床病理指标进行了多元分析。选出１２项良恶鉴别的指标，建立了ｌｏｇｉｓｔｉｃ判别方程，判别符合率１００％。１４１例获随访结果，其中１１６例随访达１０年以上。随防结果分析显示ＦＣ微小浸润型和明显浸润型自下而上率差异显著，１１项临床病理指标对ＦＣ有预后意义。     

99mTc-depreotide生长抑素受体显像的临床应用研究

生长抑素受体显像近年来研究较多，depreotide已成为其研究热点之一。Depreotide在诊断与鉴别诊断临床常见的孤立性肺结节方面有其独特优势；此外，^99mTc—depreotide生长抑素受体显像在乳腺癌、甲状腺癌、淋巴瘤等肿瘤及甲状腺相关性眼病等非肿瘤性疾病也有一定应用前景。     

Lack of modifying effects of atrazine and/or tamoxifen on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN)

The modifying effects of atrazine, and/or tamoxifen, on thyroid carcinogenesis were investigated in a rat two-stage carcinogenesis model following N-bis(2-hydroxypropyl)nitrosamine (DHPN) initiation. Five-week-old male F344 rats were given a single subcutaneous injection of DHPN (2800 mg/kg, body weight) or vehicle alone. Starting 1 week later, the animals were fed a diet supplemented with 0, 5, 50 or 500 ppm of atrazine, 500 ppm atrazine plus 5 ppm tamoxifen, or 5 ppm tamoxifen in the DHPN-treated groups, and 0 or 500 ppm of atrazine in the DHPN-untreated groups for 24 weeks. At autopsy major organs, including the thyroid, pituitary, liver, kidney, testis, epididymis, and brain, were collected and histopathologically examined. Body weights were significantly (P<0.05) decreased by the high doses of atrazine or tamoxifen, the effect being enhanced in combination. Relative thyroid weights were significantly increased (P<0.05) only in the tamoxifen-treated group and pituitary weights were elevated with 500 ppm atrazine plus tamoxifen (P<0.05). Relative liver weights were increased by the high dose of atrazine. However, the atrazine and/or tamoxifen treatments did not induce significant histopathological changes in the major organs, including the thyroid, nor cause significant changes in serum TSH levels. These results suggest that neither atrazine nor tamoxifen may promote thyroid carcinogenesis, alone as well as in combination.     

He—Ne激光治疗声带小结的机理研究

我院应用He－Ne激光治疗551例声带小结，取得较好疗效。为研究作用机理，我们进行了免疫功能测定、测温试验、He－Ne激光照射前后的间接喉镜检查、显微结构研究、抑菌试验和过氧化脂质测定。结果提示He－Ne激光照射治疗声带小结的机理为照射后喉部温度升高、血管扩张、血循环加快，从而增强局部营养，促进喉部粘膜生长、消除组织水肿，加速炎性渗出物和毒素的排泄。而He－Ne激光本身没有杀菌和抑菌作用。     

The external laryngeal nerve: surgical and anatomic considerations. Report of 50 total thyroidectomies

This surgical anatomy study aimed to evaluate the possibility of identifying the external laryngeal nerve during thyroid surgery and the possible variations of nerves at risk. Fifty patients underwent total thyroidectomies during a period of 12 months. Using a neurostimulator, the distal motor branch of the external laryngeal nerve was searched. Electrical stimulation of a nervous branch aimed to provoke a global contraction of the cricothyroid in order to identify with certitude the external laryngeal nerve. The external laryngeal nerve was identified in 20% of cases. Its course was, with almost equal frequency, either (1) between the vessels of the superior thyroid pedicle or (2) superficial and anterior to the fascia of the cricothyroid muscle. The external laryngeal nerve is hard to find during thyroid surgery, even with a neurostimulator. It can be vulnerable during thyroid surgery but only in cases of anatomic variations. Searching for the nerve systematically during thyroid surgery does not seem to be useful. Several precautions when dissecting the superior pole of the thyroid gland seem to be necessary and sufficient to respect the external laryngeal nerve.