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101.
Kuebler JF Kos M Jesch NK Metzelder ML van der Zee DC Bax KM Vieten G Ure BM 《Journal of pediatric surgery》2007,42(1):244-248
Background
Superoxide anions released by activated macrophages during surgery are considered to be responsible for local cellular damage. Application of CO2 pneumoperitoneum during laparoscopy affects superoxide anion release, but the underlying mechanism remains unclear and the data reported are conflicting. We investigated the direct and pH-mediated impact of CO2 and air on macrophage superoxide anion production.Methods
Cells of the NR 8383 rat macrophage cell line were incubated for 2 hours in 5% CO2, 100% CO2, and room air or pH 7.4, pH 6.5, and pH 5.5. The extracellular pH was monitored during incubation. At 0, 2, and 6 hours after incubation, the release of superoxide anions was determined fluorometrically. The mitochondrial activity was determined via the conversion of MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] during and after incubation.Results
Extracellular pH decreased to 6.4 during incubation in a CO2 atmosphere. The release of superoxide anions was significantly reduced immediately after CO2 incubation. It was restored at all other time-points. Decreasing the extracellular pH to 6.5 had no effect on superoxide anion release, whereas acidification of the extracellular milieu to pH 5.5 significantly suppressed subsequent superoxide release. Mitochondrial activity was significantly decreased by CO2 up to 2 hours and by acidic milieu up to 6 hours. Incubation in room air had no effect.Conclusions
Incubation in CO2 can directly suppress macrophage superoxide anion production. This effect is of short duration, fully reversible, and not correlated to changes in extracellular pH or mitochondrial activity. Air contamination does not affect macrophage superoxide anion release. We speculate that CO2 pneumoperitoneum could attenuate the intraoperative free radical production by directly inhibiting superoxide anion release of macrophages without long-lasting suppression of macrophages and their capacity to release superoxide anions postoperatively. 相似文献102.
目的:评估可弯曲内科胸腔镜在恶性胸腔积液诊断中的应用价值。方法:对2007年10月-2010年6月的32例恶性胸腔积液患者行可弯曲内科胸腔镜检查的结果进行回顾性分析。所有患者在行内科胸腔镜检查前,其胸腔积液常规、生化、微生物学及细胞学等实验室检查均未能明确病因。结果:32例恶性胸腔积液患者中肺癌28例(腺癌22例、低分化癌6例),淋巴瘤2例,恶性胸膜间皮瘤2例。术后发热1例,未发生其他严重不良事件。结论:可弯曲内科胸腔镜是一种操作简便、安全而有效的诊断方法。对经其他常规检查无法明确诊断,且临床不能排除恶性胸腔积液时,应及时行内科胸腔镜检查以明确诊断。 相似文献
103.
Extralobar pulmonary sequestrations are most commonly found within the thoracic cavity, but have been described within the abdomen. We present the case of a 16-month-old boy with an intradiaphragmatic pulmonary sequestration and demonstrate a computed tomographic scan finding that might help identify this extremely rare abnormality preoperatively. 相似文献
104.
Marilee Carballo Mary S. Maish Dawn E. Jaroszewski Amy Yetasook Karl Bauer Robert B. Cameron E. Carmack Holmes 《Surgical endoscopy》2009,23(9):1947-1954
Background Adenocarcinomas commonly metastasize to the lungs and can be resected using open thoracotomy or video-assisted thoracic surgery
(VATS). This study reviews metastatic resections in primary adenocarcinoma patients, using both thoracotomy and VATS. We aim
to compare long-term prognoses to test the efficacy and viability of VATS.
Methods A retrospective review of primary adenocarcinoma patients who underwent resection of pulmonary metastases from 1990 to 2006
was carried out. Information was obtained by chart review. Endpoints analyzed were disease-free interval (DFI), survival time,
and recurrence-free survival (RFS).
Results In a total of 42 (16 male, 26 female; median age 58.5 years) primary adenocarcinoma patients, 21 patients underwent first
pulmonary metastatic resection using VATS (7 male, 14 female; median age 57 years) and 21 using thoracotomy (9 male, 12 female;
median age 59 years). Primary adenocarcinomas were mainly 27 colorectal (64%) and 11 breast (26%). Two VATS (10%) and three
open patients (14%) had local recurrences of the original cancer. Median postoperative follow was 13.3 months [interquartile
range (IQR) 4.5–32.8 months] for VATS and 36.9 months (IQR 19.3–48.6 months) after thoracotomy. Median DFI–1 was 22.3 months
(IQR 13.5–40.6 months) for VATS patients and 35.6 months (IQR 26.7–61.3 months) for open patients. Second thoracic occurrences
were noted in six VATS patients (median DFI–2 9.2 months), and in seven open patients (median DFI-2 21.5 months). Third thoracic
occurrences were noted in one VATS patient (DFI-3 18.7 months) and in one thoracotomy patient (DFI-3 21.8 months). Odds ratio
of recurrence showed 12.5% less chance of developing recurrence in VATS patients. Five-year RFS was 53% in VATS and 57% in
thoracotomy patients.
Conclusions VATS has become a viable alternative to open thoracotomy for resection of pulmonary metastases. In cases of primary adenocarcinoma,
VATS showed no increase in number of thoracic recurrences, and comparable RFS. Short-term follow-up is encouraging; long-term
follow-up will be needed to confirm these results. 相似文献
105.
Sohail R. Shah George K. Gittes Katherine A. Barsness Timothy D. Kane 《Surgical endoscopy》2009,23(1):215-215
Purpose Minimally invasive techniques continue to expand in pediatric surgery; however, there has been some debate over the appropriate
operative technique for the management of congenital diaphragmatic hernias in neonates [1–3]. We present a video of a thoracoscopic patch repair of a right-sided Bochdalek congenital diaphragmatic hernia (CDH) in
a 3-day-old male.
Methods Our patient was noted to have a right-sided CDH on chest X-ray following respiratory distress at the time of birth. The patient’s
remaining neonatal workup also confirmed hypoplastic transverse aortic arch with coarctation, ventricular septal defect (VSD),
and patent ductus arteriosus, which were initially diagnosed by prenatal ultrasound. After monitoring the patient for hemodynamic
stability and discussion with the family and involved pediatric cardiothoracic surgeons, the decision was made to proceed
with a thoracoscopic repair of the CDH.
Results The large right-sided CDH was noted to involve herniated small bowel, colon, and liver. The diaphragmatic defect was successfully
repaired thoracoscopically using a 5 × 5 cm polytetrafluoroethylene (PTFE) patch. The patient was extubated on the second
postoperative day and ultimately underwent aortic arch augmentation, VSD closure, and patent ductus arteriosus ligation and
division at 1 month of age. There has been no evidence of CDH recurrence in follow-up.
Conclusions As demonstrated by our video, large right-sided congenital diaphragmatic hernias requiring patch repair can be successfully
repaired thoracoscopically with appropriate surgeon comfort and experience. This minimally invasive approach may also be used
in neonates with associated cardiac defects with appropriate cardiothoracic surgical consultation and support. To our knowledge
this is the first reported case of a thoracoscopic repair of a Bochdalek (posterolateral) hernia with a prosthetic patch in
a neonate with significant congenital cardiac anomalies.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
106.
经右胸前侧入路电视胸腔镜下胸腺切除治疗重症肌无力 总被引:2,自引:0,他引:2
目的 探讨经右胸前侧入路电视胸腔镜手术(VATS)胸腺切除治疗重症肌无力(MG)的可行性及疗效.方法 回顾性分析2001年8月至2007年10月采用经右胸前侧入路VATS胸腺切除治疗MG的56例患者的临床资料.结果 55例患者通过VATS顺利完成胸腺(或胸腺瘤)与前纵隔脂肪切除.平均手术时间(96.2±52.1)min,平均术中出血量(68.7±21.4)ml.2例患者术中发生左头臂静脉损伤;1例术中结扎止血,1例中转开胸止血后完成手术.切除胸腺及纵隔脂肪组织平均(22.1±9.2)g.术后病理检查示胸腺增生38例,胸腺萎缩5例,胸腺瘤12例,胸腺囊肿1例.1例(1.8%)患者因出血于术后第8天死亡.1例(1.8%)患者术后发生重症肌无力危象.平均住院时间(7.9±2.9)d.术后MG完全缓解8例(14.3%),部分缓解39例(69.6%),无变化7例(12.5%),总有效率83.9%.结论 利用VATS经右胸前侧入路行胸腺切除安全可行,治疗MG效果满意. 相似文献
107.
Rothenberg SS 《Journal of pediatric surgery》2008,43(1):40-45
Purpose
This study evaluates the safety and efficacy of thoracoscopic lobectomy in infants and children.Methods
From January 1995 to March 2007, 97 patients underwent video-assisted thoracoscopic lobe resection. Ages ranged from 2 days to 18 years and weights from 2.8 to 78 kg. Preoperative diagnosis included sequestration/congenital adenomatoid malformation (65), severe bronchiectasis (21), congenital lobar emphysema (9), and malignancy (2).Results
Of 97 procedures, 93 were completed thoracoscopically. Operative times ranged from 35 minutes to 210 minutes (average, 115 minutes). There were 19 upper, 11 middle, and 67 lower lobe resections. There were 3 intraoperative complications (3.1%) requiring conversion to an open thoracotomy. Chest tubes were left in 88 of 97 procedures for 1 to 3 days (average, 2.1 days). Hospital stay ranged from 1 to 12 days (average, 2.4 days).Conclusions
Thoracoscopic lung resection is a safe and efficacious technique. It avoids the inherent morbidity of a major thoracotomy incision and is associated with the same decrease in postoperative pain, recovery, and hospital stay as seen in minimally invasive procedures. 相似文献108.
目的探讨围术期护理干预在电视胸腔镜手术(VATS)肺部感染预防中的应用效果。方法回顾性分析本科2009年5月2013年3月开展的50例胸腔镜手术资料及随访情况,总结围术期护理干预对并发症的预防作用。结果本组50例患者手术均获成功,术后发生肺不张1例,肺部感染4例,胸腔积液2例,持续肺漏气(肺泡胸膜瘘)3例,低氧血症1例,无胸内活动性出血。术后发热4例,痰培养阳性6例。随访1~3个月,生活质量恢复良好。结论围术期护理干预对保证VATS效果及预防术后并发症有重要作用。 相似文献
109.
电视胸腔镜(VATS)治疗自发性气胸患者的健康教育 总被引:1,自引:0,他引:1
目的 探讨对自发性气胸患者实施健康教育的护理经验。方法 将100例自发性气胸患者在入院时随机分为观察组和对照组各50例,其中观察组实施全程健康教育;对照组不实施全程健康教育。通过电话随访比较2组患者术后满意度的差别。结果 观察组满意率为93.8%,高于对照组的72.9%,差异有显著性(P〈0.05)。结论 通过有针对性的健康教育,不仅有利于患者的康复,更有利于患者自护能力的培养。 相似文献
110.
Mohsen Karami Brice Ilharreborde Etienne Morel Franck Fitoussi Georges-François Penneçot Keyvan Mazda 《European spine journal》2007,16(9):1373-1377
A retrospective study of 21 patients with idiopathic scoliosis who underwent endoscopic thoracoplasty was done. The objective
of the study was to report and assess the morbidity and mid term outcomes of video-assisted thoracoplasty in idiopathic scoliosis.
Patients with idiopathic scoliosis often present cosmetic complaints due to their rib deformity. This deformity may still
exist after surgical correction of the main scoliotic curve. Endoscopic thoracoplasty has been reported as a safe method in
limited cases of idiopathic scoliosis. Between 2002 and 2004, 21 patients underwent endoscopic anterior release and thoracoplasty
for significant rib hump deformity associated with idiopathic scoliosis. Patients were operated on lateral position, with
two endoscopic ports. Anterior release and rib resection were performed during the first stage, and instrumented posterior
fusion was performed in a second stage. Patients were evaluated preoperatively, 1 week after surgery, 6 months after surgery
and at their most recent follow-up with clinical and radiological measurement of the rib deformity. The mean age at surgery
was 14.9 years old (range 13–17 years). The average Cobb’s angle of the main scoliotic curve was 70° (range 60°–85°). Average
follow-up was 25 months (range 23–32 months). The mean number of resected ribs was five ribs (range 4–7) and the mean length
of the resected rib was 4.2 cm (range 2.2–7 cm). Average operating time of endoscopic thoracoplasty (including anterior release)
was 65 min (range 45–108 min). The mean preoperative height of rib hump deformity was 3.6 cm (range 2.5–5.5 cm). It was reduced
to 1.5 cm at most recent follow-up. There was no significant thoracic pain necessitating medication postoperatively. No complications
related to endoscopic anterior release and rib hump resection occurred in the series. Endoscopic thoracoplasty is a safe and
reliable technique in idiopathic scoliosis. If indicated, the anterior release can be performed with video-assistance and
the thoracoplasty can be performed on the same stage. 相似文献