Hydrophobicity of β-adrenoceptor blocking agents: Study of correlations between retention in reversed-phase HPLC systems and octanol-water partition constants

The capacity factors (k′) of seven β-adrenoceptor blocking agents in six different reversed-phase HPLC systems have been determined. Octanol-aqueous buffer (pH 7.4) partition constants (P) for these blocking agents were also obtained. By using target factor analysis (TFA), good empirical correlations between the log k′ and log P were derived. The resulting hydrophobicity order agrees well with the metabolic elimination pathways of these drugs.     

胃癌病人NK细胞活性变化机理的初步研究

应用~(51)Cr释放试验和效靶结合试验,同时测定了正常人和胃癌病人外周血NK细胞活性与靶结合细胞数(TBC),研究了正常人及病人血浆对NK细胞功能的影响。发现正常人NK细胞活性与靶结合细胞数之间的关系呈直线正相关,但在NK活性降低的病人中靶结合细胞数却无明显改变,二者无相关性,而病人的血浆对正常人外周血NK活性则有明显的抑制作用(P<0.05),且抑制率与胃癌人NK细胞活性存有着负相关的关系,提示胃癌病人血浆具有抑制NK细胞活性的物质。     

选择性靶动脉栓塞在骶骨肿瘤切除术中的价值

目的 探讨和评估选择性靶动脉栓塞骶骨肿瘤后对外科切除肿瘤的价值和方法。方法 运用Seldinger技术，对9例骶骨肿瘤患者进行肿瘤供血动脉及肿瘤内血管全部彻底栓塞，栓塞材料应用明胶海绵，栓塞后1周内行手术切除术。结果 彻底的术前栓塞手术中失血量明显减少，9例骶骨肿瘤均得到彻底切除，平均失血量为1090ml。术后平均随访15个月，未见肿瘤局部复发。结论 骶骨肿瘤切除术前选择性靶动脉栓塞可有效减少术中出血，有利于肿瘤的彻底切除，为顺利切除骶骨肿瘤提供了有价值的方法。     

立体定向治疗中靶心定位的算法

本文介绍了在立体定向放射神经外科中，根据病人配戴头环和ＣＴ定标架作ＣＴ扫描所得的ＣＴ断层图像或配戴ＡＶＭ定位箱做血管造影得到的两张Ｘ光片确定病人颅内病灶的三维坐标的方法。     

Effects of ethanol on murine aggression assessed by biting of an inanimate target

The effects of acutely administered ethanol (0, 0.5, 1.0 and 2.0 g/kg, IP) were studied in a tube-restraint/target biting model of aggressive responding using naive group-and individually-housed male Swiss mice. Behavioural measures were the latency to the first bite and the biting frequency. In saline-injected control animals, the levels of responding were significantly higher in group-housed than isolated mice. Animals given alcohol exhibited a dose-dependent suppression of biting frequency, and an increase in biting latency. Mice experienced in the tube-testing situation showed reduced baseline levels of biting, but alcohol produced similar effects to those in naive mice. There was no evidence of a biphasic action of alcohol.     

目标管理在医疗设备维修管理中的应用与效果分析

分析目标管理在医疗设备维修管理中的应用效果,选取2019年1月至2020年12月医疗设备维修数据,对比分析实施目标管理前后的设备整体平均维修时长、维修关单良好率、基础性设备(病床、监护仪及泵类)平均维修时长和工程师维修关单良好率,为医院维修管理精细化实践提供参考。     

神经系统轴突三维定向生长的数值模拟

目的研究轴突在三维组织中的定向生长问题,探讨轴突沿非平坦基底定向生长时基底的低起伏程度对轴突的生长速率、成束和解束速率的影响。方法根据实验观察,设轴突生长的牵引力与靶细胞分泌的可扩散吸引分子的浓度梯度成正比,轴突成束和解束的侧向力与生长锥分泌的可扩散吸引分子和排斥分子的浓度梯度成正比,并且,吸引力指向浓度高的方向,排斥力指向浓度低的方向,浓度满足扩散方程。对于非平坦基底,有效力为沿基底轮廓线的切向分量。数值计算采用三维有限差分法和改进的Euler法。结果(1)轴突在三维组织中定向生长的基本特征与在二维培养基实验中的观察是一致的,只是在形态上有三维与二维之分;(2)非平坦基底的低起伏程度影响轴突的生长,随着起伏加剧,生长锥的前进速率减小、侧向速率增加。结论(1)许多基于二维培养实验所揭示的轴突生长的基本规律在三维情况下仍然是成立的;(2)基底的几何性质是影响轴突生长速率的重要因素之一。     

神经系统轴突生长的数值模拟

目的数值模拟神经系统在发育过程中轴突的生长情况。方法根据神经发育原理,建立具有一定刚性的非线性混合抛物型偏微分方程组,运用ADI差分格式和改进的欧拉法作数值分析。结果 (1)在一个正方形平面区域内有10个轴突以相等的间距围成圆形,当中心有1个靶细胞时,轴突生长路径的数值模拟结果与前人所做的有关结果一致;(2)轴突的初始位置同(1),当中央有4个两两上下并排分布的靶细胞时,数值模拟结果很好地反映了轴突生长时的趋化性;(3)在区域的近上、下边界分别有一串靶细胞和一串轴突时,数值模拟结果较好地反映了轴突结集生长时的成束和解束现象。结论本文给出的数学模型和数值主法能够较好地模拟有关实验所观测到的主要现象。     

动态血压正常高限者的左室肥厚

目的：观察动态血压为正常高限者的左室肥厚情况,为该患者群靶器官损害的防治策略提供依据。方法：根据２４小时动态血压监测结果将病人分为３组：Ｎ组（正常血压组）、ＮＨ组（血压正常高限组）和Ｈ组（高血压组）。以超声心动图检测左室舒张末期内径,舒张末期室间隔和左室后壁厚度等,计算左室重量指数（ＬＶＭＩ）。结果：Ｈ组（１２９±４１）和ＮＨ组（１１５±３２）的ＬＶＭＩ明显高于Ｎ组（９７±２３,Ｐ＝０．００００１和０．００５）,Ｈ组和ＮＨ组间无统计学差异。结论：动态血压正常高限者左室肥厚程度明显重于血压完全正常者。对该人群亦应积极采取措施预防和治疗靶器官损害     

Development and inhibition of the target phenomenon in tenotomized rat muscle

Summary The sequence of development of the target phenomenon in tenotomized gastrocnemius muscle was studied: the presence of target fibres was preceded by the occurrence of contraction bands and of moth eaten appearance of the fibres. This phenomenon was far more pronounced and occurred earlier in type II than in type I fibres.This target phenomenon and the contraction artefacts could be inhibited in the tenotomized muscles by simultaneous neurotomy or immobilization of the muscle with a plaster cast. Delayed denervation inhibited also the target phenomenon, if performed less than 5 days after the tenotomy. These series of experiments seem to indicate that the target phenomenon occurs in more irritable muscle fibres and that muscular activity is needed for its development.