开环式微创肛肠吻合器痔切闭术治疗脱垂性痔病的临床研究

目的　探讨开环式微创肛肠吻合器痔切闭术( TST 术)治疗Ⅲ°-Ⅳ°痔的疗效与并发症。方法　将100名Ⅲ°-Ⅳ°痔病患者随机分为实验组( TST 组) 和对照组(PPH 组)各50例 ,治疗后比较疗效与并发症。结果　实验组与对照组疗效差异无统计学意义( P > 0.05);手术时间、住院时间、术后肛门疼痛、肛缘水肿两组间差异无统计学意义( P > 0.05) ;术后肛门坠胀、急便感、尿潴留实验组发生率低,比较差异具有统计学意义( P < 0.05)。结论　TST术治疗脱垂性痔病疗效确切,并发症发生率低,手术对肛门精细控便能力影响小,值得临床推广运用。     

Mycobacterium tuberculosis infection in systemic lupus erythematosus patients

Aim of the work

To estimate prevalence of tuberculosis (TB) infection in systemic lupus erythematosus (SLE) patients; to study its relation to disease duration, activity, damage and treatment as well as to compare the performance of interferon gamma (IFN-γ) release assay and tuberculin skin test (TST) in detection of TB infection.

双TST术治疗环状混合痔的临床疗效

目的观察双TST(Tissue-selecting Therapystapler)术治疗环状混合痔的治疗效果。方法选取2015年2月~2016年6月我院胃肠外科收治的60例环状混合痔患者为研究对象,按住院号单双分为实验组(n=30,采取双TST术式)和对照组[n=30,采取PPH(Procedure for Prolapsing Hemorrhoids)术式]。两组在治愈率、切下组织的量、手术及住院时间、术后切口疼痛、水肿、出血、吻合口狭窄以及复发、肛门坠胀率等方面进行比较。结果两组在手术、住院时间进行比较,差异无统计学意义(P0.05),在切下组织的量、水肿、疼痛、出血及吻合口狭窄、术后复发肛门坠胀率方面实验组明显优于对照组,差异具有统计学意义(P0.05)。结论相对于PPH,双TST术在治疗环状混合痔中具有更好的疗效。     

Utility of a combination of RD1 and RD2 antigens as a diagnostic marker for tuberculosis

We evaluated the diagnostic potential of a cocktail of 4 antigens encoded by regions of difference (RD) 1 and 2 of Mycobacterium tuberculosis, that is, early secretory antigenic target-6, culture filtrate protein-10 (CFP-10), CFP-21, and mycobacterial protein from species tuberculosis-64 (MPT-64) on the basis of antigen and antibody detection by enzyme-linked immunosorbent assay. Parallel detection of antigens and antibodies in the serum samples of pulmonary tuberculosis (PTB) patients resulted in higher sensitivity as compared to either of the single tests in both smear-positive (90%) and smear-negative (60%) PTB patients. In addition, combined detection of antigens and antibodies in the fluids of extrapulmonary tuberculosis (EPTB) patients could detect >90% of the patients with high specificity. These results demonstrate the ability of the combination of antigen and antibody detection assays based on the cocktail of RD antigens to diagnose a substantial number of PTB and EPTB cases with high specificity.     

Antidepressant effect of Yueju-Wan ethanol extract and its fractions in mice models of despair

AIM OF THE STUDY: Yueju-Wan (YJ), a traditional Chinese medicinal formula, is commonly used for the treatment of depression-related syndromes in China. This study was conducted to evaluate the antidepressant activity of YJ ethanol extract (YJ-E) and its four different fractions, the petroleum ether fraction (YJ-EA), ethyl acetate fraction (YJ-EB), n-butanol fraction (YJ-EC) and final aqueous fraction (YJ-ED). MATERIALS AND METHODS: Two experimental despair animal models: the mice tail suspension test (TST) and the mice forced swimming test (FST) were used to evaluate the antidepressant activity of YJ-E and its fractions. These extracts or fractions were administered orally for 7 days, while the parallel positive control was given at the same time using fluoxetine hydrochloride (FLU) in TST and imipramine hydrochloride (IMI) in FST respectively. RESULTS: YJ-E high dose (YJ-E2), YJ-EA, YJ-EC and the positive control groups could decrease the duration of immobility in the TST and FST and have no significant changes in locomotor activity. YJ-E low dose (YJ-E1), YJ-EB, YJ-ED and the vehicle solvent (VEH) control group have no obvious effect on these same tests. CONCLUSIONS: In these despair animal models, YJ ethanol extract, the petroleum ether fraction and n-butanol fraction show potent antidepressant effects. The petroleum ether fraction and n-butanol fraction appear to be the active fractions of YJ-E.     

消痔灵注射液联合选择性痔上黏膜吻合术对混合痔患者肛肠动力及治疗效果的影响

【目的】探讨消痔灵注射液(由五倍子、明矾等组成)联合选择性痔上黏膜吻合术(TST)对混合痔患者肛肠动力及治疗效果的影响。【方法】选取2014年12月~2015年12月接受手术治疗的122例Ⅲ、Ⅳ度混合痔患者为研究对象,采用随机数字表法将患者随机分为观察组和对照组各61例。对照组采用传统外剥内扎术,观察组采用选择性痔上黏膜吻合术,2组均给予直肠黏膜下注射消痔灵注射液。比较2组手术指标、肛肠动力指标及临床疗效指标。【结果】(1)术后6个月,2组临床疗效、肛门狭窄程度及尿潴留评分比较,差异均无统计学意义(P0.05);(2)观察组的手术时间、术中出血量、术后疼痛、肛缘水肿评分、平均住院时间均明显低于对照组(P0.05或P0.01);(3)术后6个月,2组各项肛肠动力指标均明显改善(P0.01),且观察组的肠静息压、直肠感觉阈、直肠耐受量明显低于对照组,肛管静息压、肛管直肠压力差明显高于对照组(P0.01)。【结论】消痔灵注射液联合选择性痔上黏膜吻合术有助于减轻手术创伤,改善肛肠动力,临床疗效值得肯定。     

Ⅱ～Ⅲ度内痔TST手术20例治疗体会

目的：探讨经肛门镜下开环式微创痔上粘膜切除吻合术(Tis ue-Selecting Therapy StaplerTST)的临床效果。方法在2009年9月~2014年4月我院治疗内痔的患者中,用TST手术治疗Ⅱ~Ⅲ度痔病20例的临床资料,分析TST手术的治疗方法。结果手术时间30~50min,平均42 min。大部分患者脱出的内痔、粘膜及皮赘立即回缩到肛管内,便血症状立即消失,术后2d患者均能下床活动,患者5~7d后出院。结论TST手术对于Ⅱ~Ⅲ度内痔的治疗效果明显,属于一种安全、有效的微创疗法。     

Quality of life and mood in children with cystic fibrosis: Associations with sleep quality

Background

We aimed to investigate the relationship between sleep quality, mood and health-related quality of life (HRQOL) in children with CF and controls.