针刺治疗脑梗死作用机理的研究进展

通过综述近年来针刺治疗脑梗死在临床观察及实验研究对脑梗死损害的保护和修复作用,以及在脑血液动力学、生化与免疫学等方面的变化,来探讨针刺治疗脑梗死作用机理的问题.     

中医药治疗对胃癌血液流变学影响研究简况

中医药治疗能改善胃癌患者血液流变学指标,对全血粘度、红细胞压积、血沉等作用更加明显,能有效改善患者微循环,具有潜在临床意义,值得进一步深入研究。     

Ensemble perception of emotions in autistic and typical children and adolescents

Ensemble perception, the ability to assess automatically the summary of large amounts of information presented in visual scenes, is available early in typical development. This ability might be compromised in autistic children, who are thought to present limitations in maintaining summary statistics representations for the recent history of sensory input. Here we examined ensemble perception of facial emotional expressions in 35 autistic children, 30 age- and ability-matched typical children and 25 typical adults. Participants received three tasks: a) an ‘ensemble’ emotion discrimination task; b) a baseline (single-face) emotion discrimination task; and c) a facial expression identification task. Children performed worse than adults on all three tasks. Unexpectedly, autistic and typical children were, on average, indistinguishable in their precision and accuracy on all three tasks. Computational modelling suggested that, on average, autistic and typical children used ensemble-encoding strategies to a similar extent; but ensemble perception was related to non-verbal reasoning abilities in autistic but not in typical children. Eye-movement data also showed no group differences in the way children attended to the stimuli. Our combined findings suggest that the abilities of autistic and typical children for ensemble perception of emotions are comparable on average.     

八珍汤在骨伤科应用研究进展

八珍汤作为气血双补的经典方,临床多用于治疗气血亏虚证型的疾病。近些年随着八珍汤在抗凝、抗氧化、抗衰老、提高免疫、提高造血等药理研究的深入,其已广泛应用于内外妇儿、肿瘤、骨伤等领域。文章主要从中医理论和西医血液系统、免疫系统等介绍八珍汤在骨伤科应用的研究进展。     

Comparing two botulinum toxin type A formulations using manufacturers' product summaries

Background and objective: Because of the unique pharmacology and clinical versatility of botulinum toxin (BoNT), particularly BoNT serotype A (BoNTA), a need exists for discussion of the current data on similarities and differences between two BoNTA products, BOTOX and Dysport. Methods: We compared the physiochemical and pharmacological properties of BOTOX and Dysport using information from the Summary of Product Characteristics (SmPC) documents from a number of countries around the world. Results and discussion: Our analysis based on the SmPC documents demonstrated distinct differences in physical characteristics, breadth of approved indications, dosing and administration, and the incidence and severity of adverse events. Conclusion: BOTOX and Dysport are not bioequivalent. Many of the differences between BOTOX and Dysport discussed within are probably related to the differences in their physical characteristics.     

神经性厌食患者饮食行为管理的最佳证据总结

目的 检索、评价并整合国内外神经性厌食患者饮食行为管理的相关证据,为临床护理提供参考。方法系统检索国内外数据库中有关神经性厌食患者饮食行为管理的临床决策、推荐实践、证据总结、临床实践指南、系统评价/Meta分析和专家共识。检索时限为建库至2022年2月,由3名研究者对文献进行方法学质量评价,并根据主题对证据进行提取和汇总。结果 共纳入16篇文献,其中临床决策2篇,证据总结2篇,指南9篇,系统评价3篇。从多学科团队、管理目标、评估、管理实践、心理治疗、健康教育6个方面汇总26条最佳证据。结论 该研究总结了神经性厌食患者饮食行为管理的最佳证据,在后续证据转化过程中应结合国内临床具体情境,有针对性地选择证据,以规范患者饮食行为,改善其临床结局。     

Reasons for Distress Among Burn Survivors at 6, 12, and 24 Months Postdischarge: A Burn Injury Model System Investigation

Objective

To identify important sources of distress among burn survivors at discharge and 6, 12, and 24 months postinjury, and to examine if the distress related to these sources changed over time.

成人外科术后患者口渴管理的最佳证据总结

目的 总结成人外科术后患者口渴管理的相关证据,为临床护理人员处理口渴症状提供参考依据。方法 以“6S”证据资源金字塔模型为基础,检索与成人外科术后口渴相关的实践指南、专家共识、证据总结、临床决策、推荐实践和系统评价,检索时限为建库至2022年12月31日,2名研究人员独立开展文献筛选、质量评价和证据综合。结果 共纳入11篇文献,包括1篇实践指南、3篇证据总结、4篇系统评价、3篇专家共识,分别从口渴评估、干预策略、效果评价、教育培训这4个方面归纳出13条证据。结论 该研究总结的成人外科术后患者口渴管理的最佳证据具有一定的科学性和可行性,可以结合患者具体情况针对性地应用证据,最大程度的提高患者舒适度。