Jansen type of spondylometaphyseal dysplasia

Metaphyseal dysplasia, type Jansen (JMD), is a rare skeletal dysplasia with characteristic radiographic abnormalities. Of the various types of metaphyseal dysplasia, JMD shows the most severe alteration in metaphyseal architecture. All of the long tubular bones, including those of the hands and feet, show metaphyseal irregularity with a fragmented appearance and slight widening. The adjacent physes are abnormally widened, while the epiphyses tend to be slightly enlarged, rounded but otherwise normal. The spine in infancy and childhood usually appears normal. This report describes a young girl with metaphyseal changes typical of JMD except for the hands and feet, which appeared normal. She also showed very unusual abnormalities of the spine. This appears, therefore, to represent a unique osteochondrodysplasia for which we propose the term spondylometaphyseal dysplasia, type Jansen. Received: 4 April 1999 Revision requested: 6 April 1999 Revision received: 29 November 1999 Accepted: 1 December 1999     

不孕不育者对人工授精技术的伦理态度调查研究

目的：研究不孕不育者对人工授精技术的伦理态度,促进该项技术更好地为患者服务.方法：自制问卷调查了223名不孕不育者.结果：不孕不育者对AIH、AID的态度存在显著差异（P＜0.05）;对婚姻家庭生活选择相对宽容;精子的商品化趋向值得关注;必须采取一定措施以保证精子和人工授精儿的质量.结论：AID会引发许多伦理问题,临床应用时更应遵循有利于患者、知情同意等伦理原则和相关法律规定,以减少纠纷,造福社会.     

不孕不育者与公众对人工授精技术伦理态度的对照研究

目的：研究不孕不育者与公众对人工授精技术的伦理态度的差异,促进该项技术更好地在临床应用.方法：自制问卷分别调查了220名不孕不育者和720名社会各类人员,对调查结果进行对照研究.结果：不孕不育者与公众在对待AIH的态度、AIH对夫妻感情影响的态度、AID中抚养、赡养问题的态度、给供精者提供“营养费”的态度、精子买卖的态度、AID人工授精儿信息告知的态度、单身女子选择人工授精的态度、AID人工授精儿成年后寻找供精者权利的态度、AID是否会造成亲属关系混乱的态度上均存在着显著差异（p＜0.05）.结论：不孕不育者作为人工授精技术的＂潜在主体＂对待该项技术的伦理态度比公众更加理性和谨慎.     

Forensic identification of skeletal remains from members of Ernesto Che Guevara’s guerrillas in Bolivia based on DNA typing

We report the positive identification of several members of the guerrillas led by Ernesto “Che” Guevara on the 1960 s in Bolivia by means of DNA fingerprinting. Successful DNA typing of both short tandem repeat loci and the hypervariable region of the human mitochondrial DNA was achieved after extracting total DNA from bones obtained from two burial sites. Given the size of the Cuban database for the STR allele frequencies, a conservative approach was followed to estimate the statistical significance of the genetic evidence. The estimated probabilities of paternity for the two cases in which the paternity logic was applied were higher than 99%. One case was analyzed using mitochondrial DNA and could not be excluded from the identity proposed by the forensic anthropology team. A fourth case was identified by exclusion, on the basis of the positive identification of the other remains, the historical and other anthropological evidence. Received: 19 January 1999 / Received in revised form: 15 April 1999     

短重建髓内钉在高龄股骨粗隆间骨折的临床应用

目的探讨短重建髓内钉治疗老龄患者股骨粗隆间骨折的临床应用。方法 2006年7月至2010年3月间,使用短重建髓内钉内固定手术治疗56例股骨粗隆间骨折老龄患者,分析评价其特点及治疗效果。结果手术切口平均长度为3.5cm,平均手术时间70min,平均术中出血量60ml;所有患者均获得术后随访。术后无深静脉血栓和伤口感染等并发症,1例术后第5周出现股骨钉松脱;1例术后17个月发生骨不连,需行切开植骨术。结论短重建髓内钉治疗股骨粗隆间骨折具有手术耗时少,组织创伤小,术后内固定稳定性强,围手术期并发症少,患肢功能恢复快等优点,应成为治疗老龄股骨粗隆间骨折的首选内固定方法。     

1237例夫精宫腔内人工授精周期临床妊娠结局探讨

目的:探讨患者年龄,不孕年限,输卵管通畅度和注入宫腔内前向运动精子总数(NMSI)对夫精宫腔内人工授精(AIH)临床妊娠率的影响,旨在更好地指导临床工作.方法:选取835对夫妻1 237个AIH周期,按年龄分为:≤35岁、36～39岁、≥40岁组;按不孕年限分为:＜2年、2～4年及＞4年;按输卵管通畅度分为:双侧输卵管通畅、单侧输卵管通畅和双侧输卵管不全通畅组;按处理后NMSI分为＜2、2～5、5～10及＞10×106组.结果:临床妊娠175例,周期妊娠率为14.1％,夫精宫腔内人工授精临床妊娠的成功率随着患者年龄及不孕年限的增加而降低,差异具有统计学意义(P＜0.05);注入宫腔内前向运动精子总数(NMSI)小于5×106时临床妊娠率低,差异具有统计学意义(P＜0.05);双侧及单侧榆卵管通畅组妊娠率高于双侧输卵管不全通畅组.结论:年龄≥40岁,不孕年限＞4年,处理后注入宫腔内前向运动精子总数(NMSI)小于5×106或双侧输卵管不全通畅的患者,不适合继续尝试IUI治疗.