剪切波弹性成像与FNA-Tg对甲状腺乳头状癌侧颈部淋巴结转移的诊断价值

目的：探讨剪切波弹性成像(shear wave elastography,SWE)与细针穿刺洗脱液甲状腺球蛋白(fine-needle aspiration washout thyroglobulin,FNA-Tg)对甲状腺乳头状癌侧颈部淋巴结转移的诊断价值。方法：回顾性分析159例经病理证实为甲状腺乳头状癌(papillary thyroid carcinoma,PTC)的患者资料,对颈部211枚可疑淋巴结进行常规超声、SWE参数平均值(E_mean)、FNA-Tg检查,以术后病理结果为金标准,比较各检测方法的诊断效能。结果：(1)SWE E_mean转移组[(50.96±27.66) kPa]高于非转移组[(32.20±17.34) kPa],差异有统计学意义(t=8.761,P<0.01)。受试者工作特征(receiver operating characteristic,ROC)曲线分析表明,SWE E_mean最佳诊断阈值为40.42 kPa时对PTC颈部淋巴结转移预测价值较高,曲线下面积(area under...     

基于实时超声弹性成像技术评价 调经促孕针刺法对卵巢早衰的疗效研究

目的 探讨实时超声弹性成像技术对调经促孕针刺法治疗卵巢早衰疗效的评估价值.方法 选取2019年1月～2020年5月深圳市中医院针灸门诊及病房的60例卵巢早衰患者为研究对象.所有患者均接受调经促孕针刺法治疗,每周3次,连续治疗3个月经周期,对于闭经者,连续治疗3个自然月.观察患者治疗前后血清激素水平变化,并采用实时超声弹...     

N-乙酰-5-羟色胺的电化学检测研究

采用方波溶出伏安法(OSWSV),建立了N-乙酰-5-羟色胺的—种新型快速、灵敏的测定体系。实验研究了富集条件、pH值对方波溶出伏安法对N-乙酰-5-羟色胺的影响。在pH=9.33的硼砂-氢氧化钠缓冲液中,N-乙酰-5-羟色胺在约0.2V(vs.Ag/AgCl)电位处产生一个阳极氧化峰,峰电流与浓度在1.0×10-7~1.0×10-4mol.L-1范围内成线性关系,N-乙酰-5-羟色胺检测限为1.2×10-8mol.L-1。进行尿样样品测定,回收率为81.8%,结果良好。     

Can the unnecessary operations for suspected thyroid nodules be avoided by the combined use of the strain ratio and elastography score?

IntroductionOnly 5%–15% of thyroid surgical specimens are reported as malignant. Most of the operations are performed due to suspicion of malignancy as a result of fine needle aspiration biopsy but invasiveness, non-diagnostic results and potential repeat biopsies are disadvantages of fine needle aspiration biopsy.ObjectiveThe aim of this study was to investigate the effectiveness of simultaneously using both the strain ratio and elasticity score in the differential diagnosis of thyroid nodules, as well as to assess the compatibility of these two methods.MethodsA total of 144 nodules were included in the study. The final histopathologic diagnosis was used as the reference standard. The area under the curve sensitivity, specificity, and cut-off values of the strain ratio and elasticity score were determined using receiver operating characteristic curve analysis. The compatibility and comparison of strain ratio and elasticity score were also performed.ResultsTwenty eight nodules (19.4%) were malignant. The strain ratio and elasticity score results were found to be significantly successful in predicting thyroid malignancy (p < 0.001 for both). Moreover, the area under the curve for the strain ratio and elasticity score were found to be 0.944 and 0.960, respectively. The diagnostic accuracy of the elasticity score was found to be superior to that of the strain ratio, but this difference was not statistically significant (p = 0.456). When the compatibility of the strain ratio and elasticity score was examined, the two evaluations were revealed to be statistically consistent with each other (Kappa = 0.767; p < 0.001). When the strain ratio and the elasticity score were used together, the specificity of capturing the correct diagnosis increased from 84.5% to 93.1%.ConclusionWhen the strain ratio an elasticity score were used together for the differential diagnosis of thyroid nodules, more accurate results were obtained. Thus, combining both methods may be a promising alternative to fine needle aspiration biopsy in order to prevent unnecessary surgical interventions for suspected thyroid nodules.     

基于SWE和MRI对临床显著性前列腺癌的诊断价值

目的：探究基于剪切波弹性成像（SWE）和多参数磁共振成像（mpMRI）对临床显著性前列腺癌（csPCa）的诊断价值。方法：回顾性选取2020年10月至2022年1月在延安大学附属医院泌尿外科疑诊为前列腺癌（PCa）并行超声引导下前列腺穿刺活检的患者为研究对象,共纳入患者74例。根据穿刺活检病理结果将患者分为PCa组与非PCa组,csPCa组与非PCa+临床不显著前列腺癌组（cisPCa）,其中PCa组24例,csPCa组17例。采用单因素及多因素logistic逐步回归分析筛选csPCa的独立预测因子,并通过ROC曲线比较预测概率值与各独立预测因子的诊断效能。结果：tPSA、fPSA、PSAD、PV、PIRADS、Emax差、Emean差和Emin差在PCa组与非PCa组,以及非PCa+cisPCa组与csPCa组之间的差异有统计学意义（P＜0.05）。logistic回归结果显示tPSA、PV、Emax差及PIRADS是csPCa的独立预测因子,ROC曲线结果显示logistic回归模型曲线下面积（AUC）为0.954,灵敏度为0.882,特异度为0.947,结果均优于各独立预测因子。结论：Emax差及PIRADS是csPCa的独立预测因子,与tPSA、PV联合具有较好的诊断效能。     

二维剪切波弹性成像技术对血液透析患者肱二头肌受损情况的量化评估

摘 要 目的 探讨二维剪切波弹性成像技术在维持性血液透析患者肱二头肌受损情况中的价值。方法 测量长透组、短透组及对照组各30名患者的肱二头肌肌肉厚度和浅侧脂肪厚度、及其剪切波速度,比较三组间各指标的变化情况。结果 （1）肱二头肌中段肌肉厚度测量中长透组（右1.98±0.35cm,左1.99±0.32cm）厚于对照组（右1.92±0.21cm,左1.94±0.19cm）和短透组（右1.81±0.30cm,左1.82±0.30cm）,其中长透组和短透组间差异有统计学意义（p＜0.05）。（2）肱二头肌中段浅侧脂肪厚度测量中对照组（右0.40（0.34,0.51）cm,左0.40（0.35,0.51）cm）厚于长透组（右0.35（0.30,0.48）cm,左0.37（0.30,0.51）cm）和短透组（右0.30（0.26,0.42）cm,左0.32（0.27,0.46）cm）,其中短透组和对照组间差异有统计学意义（p＜0.05）。（3）肱二头肌及浅侧脂肪剪切波速度测量中对照组速度最高（右3.72±0.25m/s、3.27（3.15,3.38）m/s,左3.76±0.19m/s、3.22（3.14,3.36）m/s）,其次是短透组（右3.47±0.26m/s、3.09（2.97,3.27）m/s,左3.48±0.24m/s、3.08（3.00,3.20）m/s）,再次是长透组（右3.17±0.33m/s,2.85（2.69,3.07）m/s、左3.17±0.27m/s、2.88（2.73,3.07）m/s）,各组间差异有统计学意义（p＜0.05）。结论 超声作为一种无创便捷评估维持性血液透析患者肱二头肌及其浅侧脂肪厚度及弹性模量变化的影像检查方法,可用于肌肉功能受损程度的量化评估。     

剪切波弹性成像参数联合血清中期因子、胸苷激酶1、促甲状腺素与甲状腺球蛋白比值鉴别诊断 甲状腺结节的临床价值

目的 探讨剪切波弹性成像（SWE）参数联合血清中期因子（MK）、胸苷激酶1(TK1)、促甲状腺素与甲状腺球蛋白比值（TSH/Tg）鉴别诊断甲状腺结节良恶性的临床价值。方法 选取我院经术后病理结果或穿刺结果证实的甲状腺结节患者129例,均为单发病灶,其中良性组98例,恶性组31例,均行SWE检查及血清MK、TK1、TSH、Tg检测,比较两组SWE参数[杨氏模量最小值（Emin）、最大值（Emax）、平均值（Emean）],以及血清MK、TK1、TSH/Tg的差异。应用Logistic回归分析建立SWE参数联合血清MK、TK1、TSH/Tg的诊断模型;绘制受试者工作特征（ROC）曲线分析该模型鉴别甲状腺结节良恶性的诊断效能。结果 与良性组比较,恶性组Emax、Emin、Emean及血清MK、TK1、TSH/Tg均升高,差异均有统计学意义（均P<0.05）。应用Logistic回归分析建立SWE参数联合血清MK、TK1、TSH/Tg的诊断模型为：Logit(P)=-0.069+0.101×Emean+0.353×血清MK+0.328×血清TK1+0.882×血清TSH/Tg;ROC曲线...