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51.
52.
本文用胶固素酶联免疫吸附试验检测了16例缺血性脑血管病(ICD)患者,14例出血性脑血管病(HCD)患者和20例健康正常人的血清IgE型循环免疫复合物(CID)水平。结果显示ICD组和HCD组IgE-CIC水平明显高于正常组(分别为P<0.001和P<0.05)。ICD组与HCD组间没有显著差异(P>0.02)。提示脑血管病的发生与IgE-CIC的形成有关。 相似文献
53.
对沈阳市某幼儿园99例3~6岁锌缺乏儿童的营养调查和生物样品(血液、尿液和毛发)的分析发现:同对照组儿童相比,锌缺乏儿童除Fe、维生素A外,其他主要营养素的摄入明显不足;缺锌儿童的发锌、RBC锌水平、血清ALP活性、尿锌/尿肌酐比值均明显低于对照组。经补锌治疗后血浆锌水平、血清ALP活性、尿锌/尿肌酐比值显著升高。应用临床诊断实验的评价方法分析发现结合血浆锌水平,联合使用发锌,血清ALP和尿锌/尿肌酐比值3项指标可以准确判断儿童边缘性锌缺乏,这时并联的灵敏度为96.18%,串联的特异度可高达到100%(血清ALP活性<104IU/L,同时发锌含量<110ppm.尿锌/尿肌酐比值<0.3μg/g)。 相似文献
54.
目的 探讨N -乙酰半胱氨酸 (NAC)治疗不同病期慢性阻塞性肺疾病 (COPD)的疗效。方法 49例稳定期、急性发作期COPD患者 ,随机分为观察组 (2 5例 )和对照组 (2 4例 ) ,观察组除给予常规治疗外 ,加用NAC(每次 2 0 0mg ,3/d ,连用 2个月 ) ;对照组仅给予常规治疗。治疗前后观察所有患者外周血淋巴细胞DNA损伤程度。结果 治疗前后比较 ,观察组稳定期、急性发作期DNA损伤明显降低 ,差异有显著性 (P <0 .0 5)。对照组稳定期DNA损伤程度亦有一定程度的改善 ,但差异无显著性 (P >0 .0 5) ,急性发作期DNA损伤程度降低 ,差异有显著性 (P <0 .0 5)。结论 COPD患者体内存在氧化 -抗氧化失衡 ,抗氧化治疗可降低COPD患者外周血淋巴细胞DNA损伤程度 ,急性发作期出现氧化应激。 相似文献
55.
目的探讨电离辐射诱发的基因组不稳定性效应。方法采用^60Co γ射线照射人正常肝细胞,检测克隆形成率和微核发生率,利用单细胞凝胶电泳(SCGE)技术检测DNA损伤情况。照射2、4、6、8和10Gy后传代培养,在40代后各剂量组再次统一照射2Gy,进行辐射损伤的检测。结果首次照射后,克隆形成率随受照剂量的增大而降低。存活细胞经二次照射后,SCGE结果和微核发生率结果表明,首次照射剂量与子代二次照射后的损伤程度存在剂量效应关系。结论γ射线不仅在肝细胞中产生直接的生物效应,而且还可以诱发产生可遗传的基因组不稳定性,使子代细胞中的突变频率增加,表现出滞后的遗传改变。二次事件的放大作用是研究基因组不稳定性的一种较好方法。 相似文献
56.
Twenty-six patients diagnosed as chronic schizophrenics were given injections of zuclopenthixol decanoate (cis(Z)-clopenthixol decanoate) 200 mg every 3 weeks for at least 6 months. Before treatment and on each day of injection the
patients' mental state was assessed by Brief Psychiatric Rating Scale (BPRS), 18 items. A registration of side effects and
basal laboratory data was also performed. Blood samples were drawn on each day of injection before injection and 3–7 days
after injection (time of maximum concentration). Neuroleptic activity, which was considered equivalent to the concentration
of zuclopenthixol, was determined in serum by radio-receptor assay (RRA). Based on amelioration scores ≥50% on the BPRS, 15
patients were characterized as responders and 11 as non-responders. The responder group showed a statistically significant
reduction in BPRS score, whereas this was not the case for the non-responders. Apart from a few patients, the serum concentrations
showed a low intra-individual variation, but a relatively high inter-individual variation. The responder group had a significantly
higher mean preinjection concentration than the non-responder group, whereas no significant difference was found in day 3–7
concentrations. The fluctuation of the serum concentration expressed as the ratio between maximum (days 3–7) and minimum (pre-inj.)
was found to be significantly lower for responders than for non-responders. Thus although the present study did not demonstrate
a clear relationship between serum level and clinical effect, it indicates that the best antipsychotic effect is obtained
with a serum concentration which fluctuates only slightly (the ratio max/min concentration not exceeding 2.1). 相似文献
57.
Objective: To evaluate the diagnostic value of serum neuron specific enolase and Video EEG inFebrile Convulsion of childen. Method:Serum NSE was detected by RIA on the first day and the seventh day afterseizure in 40 children with simple febrile convulsion and 18 with complex febrile convulsion. Video EEG was per-formed at 1st, 7th and 30th day in all the patients. Results: There were significant differences between NSE levels at24th hour and on 7th day after convulsion (P<0.01). NSE concentrations in patients with SFC and CFC were also 相似文献
58.
神经活素对Pc12细胞作用的初步观察 总被引:1,自引:0,他引:1
从胎脑、颌下腺、肌肉组织中制备神经活素。其性能同脑活素一样:可促进Pc12细胞的突起生长,提高其胞浆内乳酸脱氢酶活性,电泳显示二者有相同的三条带。提示:神经活素有可能替代脑活素应用于临床。 相似文献
59.
Summary A rapid and quantitative method for the determination of benzodiazepines using high-performance liquid chromatography (HPLC)
with diode-array detection (DAD) is reported. The drugs were extracted from serum, blood or post-mortem blood using C18 extraction columns. Brotizolam was used as internal standard. Experiments with spiked serum/blood samples resulted in recoveries
between 75% and 94% for all investigated benzodiazepines. Excellent linearity was obtained over the concentration range 5–1500
ng benzodiazepine/ml. The limit of detection was approximately 2 ng/ml. The detection of low therapeutic serum levels of highly
potent benzodiazepines is also possible.
相似文献
60.
A number of factors affecting the stability of propranolol HC1 during electrophoretic control were investigated. It was found that significant degradation of propranolol HC1 and hydrolysis of water occurred when a current of 15 mA was used with platinized electrodes. This degradation was thought to be due to decomposition of propranolol HC1 at the electrodes. Degradation could be significantly reduced by using uncoated platinum electrodes and currents in the range of 0 to 2.5 mA, while still allowing control of drug delivery rates. Electrode reaction processes were found at high ionic strengths and high drug concentrations but were not thought to be associated with drug decomposition. 相似文献