运动应激试验前后血清皮质醇和IL-6水平与白大衣性高血压的关系

目的探讨运动应激试验前后血清皮质醇和IL-6水平的变化及其与白大衣性高血压的关系。方法选取2014年1月至2016年8月该院收治的白大衣性高血压患者48例作为研究组,选取同期普通高血压患者30例作为普通组和30例健康体检者作为对照组。3组均在空腹状态,在功率200 W的自行车上以蹬车2min后间歇5min再重复运动直至极度疲劳,完成运动应激试验。检测比较3组运动前、运动后即刻及运动后3h的血清皮质醇和IL-6水平及平均动脉压(MAP),分析血清皮质醇和IL-6水平对白大衣性高血压的诊断价值及其与患者MAP的关系。结果与对照组比较,研究组和普通组运动前后的血清皮质醇和IL-6水平及MAP均升高;与普通组比较,研究组运动前后的血清皮质醇和IL-6水平及MAP均升高(P0.05)。研究组运动后即刻及运动后3h的血清皮质醇和IL-6水平及MAP均较运动前升高(P0.05)。ROC曲线分析结果显示,运动应激试验前后血清皮质醇和IL-6水平对白大衣性高血压的诊断价值良好,其中以运动后即刻血清皮质醇和IL-6水平联合诊断白大衣性高血压的价值最优。Pearson线性相关分析结果显示,运动应激试验前后血清皮质醇和IL-6水平与白大衣性高血压MAP均呈正相关(r分别为0.844、0.802,P0.05)。结论运动应激试验前后血清皮质醇和IL-6水平对白大衣性高血压的诊断价值良好且与其血压水平相关,可能作为白大衣性高血压诊断和病情评估的参考指标。     

Therapeutic applications of dental pulp stem cells in regenerating dental,periodontal and oral-related structures

Dental pulp stem cells (DPSCs) have emerged as a promising tool with great potential for use in tissue regeneration and engineering. Some of the main advantages of these cells are their multifaceted differentiation capacity, along with their high proliferation rate, a relative simplicity of extraction and culture that enables obtaining patient-specific cell lines for their use in autologous cell therapy. PubMed, Scopus and Google Scholar databases were searched for relevant articles related to the use of DPSCs in regeneration of dentin-pulp complex (DPC), periodontal tissues, salivary gland and craniomaxillofacial bone defects. Few studies were found regarding the use of DPSCs for regeneration of DPC. Scaffold-based combined with DPSCs isolated from healthy pulps was the strategy used for DPC regeneration. Studies involved subcutaneous implantation of scaffolds loaded with DPSCs pretreated with odontogenic media, or performed on human tooth root model as a root slice. Most of the studies were related to periodontal tissue regeneration which mainly utilized DPSCs/secretome. For periodontal tissues, DPSCs or their secretome were isolated from healthy or inflamed pulps and they were used either for preclinical or clinical studies. Regarding salivary gland regeneration, the submandibular gland was the only model used for the preclinical studies and DPSCs or their secretome were isolated only from healthy pulps and they were used in preclinical studies. Likewise, DPSCs have been studied for craniomaxillofacial bone defects in the form of mandibular, calvarial and craniofacial bone defects where DPSCs were isolated only from healthy pulps for preclinical and clinical studies. From the previous results, we can conclude that DPSCs is promising candidate for dental and oral tissue regeneration.