Nd—YAG激光在难治喉病中的应用

我科近年来,用Nd-YAG激光在支撑喉镜下,配合手术显微镜治疗了各种不适宜手术或手术疗效不满意的声门上癌、多发性喉乳头状瘤、咽喉部血管瘤等喉部疾患。经观察2年以上疗效均满意,报告如下。病例报告例1 男,56岁,1987年12月2日入院。诊断“声门上癌T_2N_0M_0”,因长期哮喘、肺功能极差,不能接受全麻手术而行激光治疗。方法:采用表面麻醉加基础麻醉。术前半小时注射阿托品0.5mg、     

声带白色样病变45例报告

声带白色样病变并非全部为喉白斑病。本文报告４５例临床诊断为喉白斑病，经病理证实仅３３例。认为，在病检前将本病统称为声带白色病变为宜；白斑病癌变主要在非典型增生的基础上进一步发展所致；非典型增生越严重，癌变的可能性越大。喉显微手术治疗可使部分患者痊愈。     

神经性肌强直症并发喉阻塞临床分析（附1例报告）

目的 探讨神经性肌强直症并发急性喉阻塞的诊断及治疗，并结合文献对此病的病因、发病机制、临床表现及诊治进行复习。方法 回顾性分析我科2000年收治的l例神经性肌强直症并发喉阻塞患者的诊治情况。结果 应用苯妥英钠加气管切开可以防治本病。结论 喉阻塞常首诊于耳鼻咽喉一头颈外科，而以神经性肌强直症并发者易造成误诊或误治，因此，保持病人呼吸道通畅，急诊行气管切开是必要的。     

正常喉区的CT解剖研究

喉的解剖较复杂,从CT图象上分辨更为困难。木文通过比较尸体喉区的断层解剖标本,从4个不同的平面,描述了喉区各结构形态大小的变化,并讨论其分布特征,这将有助于临床CT的诊断。     

光导纤维鼻喉镜检查术（附483例分析）

我院于1986年7月购进光导纤维鼻喉镜(日本町田公司生产,FLT-6型),从那时开始在我科门诊对适应的病人施行光导纤维鼻喉镜检查术,现将门诊记录较完整的483例作一分析。资料与方法 483例中,男310例,女173例。患者年     

喉癌的教学建议

1概述喉位于上呼吸消化道的关键部位,为人体的发音器官,间有呼吸及感觉功能,喉的黏膜为上呼吸道的复层鳞状上皮,受外界刺激容易发生癌变。近年喉癌的发病率有上升的趋势,据北京、上海、天津等城市统计,喉癌的年发病率男性为1.2～3.6/10万,女性为0.7～1.5/10万,我国北方地区发病率较高。中晚期的喉癌往往需要喉全切除,影响患者的生命,同时也导致部分患者丧失语言功能而致残。因此,提高对喉癌的认识,是教学的重点。2临床特点喉在发生学上可分为三部分,即声门上区、声门区、声门下区,三个部位来源于不同的胚胎原基。在肿瘤特性和临床上有不同的…     

去细胞喉支架的制备及喉肌细胞再生的可行性研究

Objective To prepare a deeelhilarized whole laryngeal scaffold by utilizing a perfusion-decellularized technique, reseed cells on it, and construct recellularized laryngeal muscles. Methods Perfusion decelluarized larynxes were obtained by common carotid arterious perfusion with detergents. Then they were performed by macroscopic view, histological examination, scanning electron microscopy (SEM) and cartilage viability. Decellularized laryngeal scaffold were then reseeded with inducted mesenchymal stem cells (MSCs). Composites were transferred into greater omentums of rabbits after one day' s adherence and harvested after eight weeks. Macroscopic view, histological examination and immunohistochemistry were performed. Results Perfusion larynxes became transparent after two hours. Histology and SEM indicated that perfnsion method shewed better deculluarized effect. More ventages and collagen fibers but no intact cell or anclei were retained in the decellularized martrix. Porosity measured by Image pro plus 6. 0 was 80. 4% ± 3.2% (x ± s). Chondrocyte vitality assay indicated chondrocyte vitality rate in the perfusion group was 86. 9% ± 1.5% . After eight weeks, vascularization formed and integrated cartilage frameworks still remained. Histological examination could clearly show the presence of muscle bundles and vessels. Immunohistoehemical examination indicated that sarcomeric-α actin expressed positively in corresponding areas. Conclusions It is feasible to reseed MSCs into the decellularized laryngeal muscle matrix for constructing tissue-engineered laryngeal muscles. This in vivo maturation into the omentum could be the first step before in situ implantation of the construct.