全文获取类型
收费全文 | 75195篇 |
免费 | 6319篇 |
国内免费 | 3032篇 |
专业分类
耳鼻咽喉 | 880篇 |
儿科学 | 1638篇 |
妇产科学 | 1351篇 |
基础医学 | 6522篇 |
口腔科学 | 1279篇 |
临床医学 | 7037篇 |
内科学 | 8053篇 |
皮肤病学 | 863篇 |
神经病学 | 2355篇 |
特种医学 | 3664篇 |
外国民族医学 | 56篇 |
外科学 | 12900篇 |
综合类 | 12477篇 |
现状与发展 | 19篇 |
预防医学 | 1991篇 |
眼科学 | 732篇 |
药学 | 4937篇 |
64篇 | |
中国医学 | 1971篇 |
肿瘤学 | 15757篇 |
出版年
2024年 | 166篇 |
2023年 | 1175篇 |
2022年 | 2375篇 |
2021年 | 3330篇 |
2020年 | 2723篇 |
2019年 | 2420篇 |
2018年 | 2248篇 |
2017年 | 2509篇 |
2016年 | 2886篇 |
2015年 | 2998篇 |
2014年 | 4885篇 |
2013年 | 4741篇 |
2012年 | 4329篇 |
2011年 | 4773篇 |
2010年 | 3818篇 |
2009年 | 3848篇 |
2008年 | 3846篇 |
2007年 | 4059篇 |
2006年 | 3599篇 |
2005年 | 3175篇 |
2004年 | 2717篇 |
2003年 | 2269篇 |
2002年 | 2083篇 |
2001年 | 1842篇 |
2000年 | 1492篇 |
1999年 | 1387篇 |
1998年 | 1176篇 |
1997年 | 1084篇 |
1996年 | 952篇 |
1995年 | 859篇 |
1994年 | 735篇 |
1993年 | 564篇 |
1992年 | 456篇 |
1991年 | 392篇 |
1990年 | 306篇 |
1989年 | 296篇 |
1988年 | 286篇 |
1987年 | 236篇 |
1986年 | 203篇 |
1985年 | 228篇 |
1984年 | 224篇 |
1983年 | 127篇 |
1982年 | 177篇 |
1981年 | 141篇 |
1980年 | 97篇 |
1979年 | 99篇 |
1978年 | 74篇 |
1977年 | 51篇 |
1976年 | 42篇 |
1975年 | 16篇 |
排序方式: 共有10000条查询结果,搜索用时 234 毫秒
31.
32.
33.
《Journal of the American College of Surgeons》2020,230(4):363-370
- Download : Download high-res image (207KB)
- Download : Download full-size image
34.
35.
《European journal of surgical oncology》2022,48(5):1062-1067
BackgroundSurgical resection is recommended for patients with resectable acinar cell carcinoma (ACC). The aim of this study was to investigate the clinical characteristics and surgical outcomes of resectable ACC in comparison to pancreatic ductal adenocarcinoma (PDAC).MethodA retrospective analysis was performed on all patients who consecutively underwent radical resection with pathologically confirmed ACC and PDAC from December 2011 to December 2018. Clinicopathologic characteristics and follow-up information were analyzed. A 1:3 propensity score matching (PSM) method was used to minimize the bias between ACC and PDAC.ResultsA total of 26 patients with ACC and 1351 with PDAC were included. Compared to PDAC, ACC tended to be larger (4.5 vs. 3.0 cm; p < 0.001) and more frequently located in the pancreatic body/tail (61.5% vs. 36.6%, p = 0.009), with lower total bilirubin levels, lower neutrophil lymphocyte ratio (NLR) levels and lower carbohydrate antigen 19-9 (CA19-9) levels and carcinoembryonic antigen (CEA) levels. There was no difference in postoperative morbidities in patients with ACC and PDAC. The median OS and RFS were longer in ACC when compared to PDAC (OS: 43.5 mo vs. 19.0 mo, p = 0.004; RFS: 24.5 mo vs. 11.6 mo, p = 0.023). After the 1:3 PSM, ACC remained to be a better histological type for OS (p = 0.024), but had comparable RFS with PDAC (p = 0.164).ConclusionPatients with ACC after radical resection had better OS than that with PDAC. However, ACC is also an aggressive tumor with a similar trend of RFS with PDAC after the matching, necessitating the multidisciplinary treatment for resectable ACC disease. 相似文献
36.
目的 探究原发灶定位与甲状腺乳头状微小癌(PTMC)颈侧区淋巴结转移的关系,评估超声检查预测颈侧区淋巴结转移的准确率。方法 回顾性分析2014年1月至2015年12月天津医科大学肿瘤医院收治的134例PTMC病人的临床资料,均行中央区淋巴结清扫+改良颈侧区淋巴结清扫。依据超声定位分组,分析癌灶位置与颈侧区淋巴结转移的关系。结果 颈侧各分区淋巴结转移发生率分别为:Ⅱ区30.6%、Ⅲ区50.7%、Ⅳ区57.5%、Ⅴ区11.3%。癌灶位于中上极者颈侧区淋巴结转移发生率高于癌灶位于下极者(89.7% vs. 75.7%,P=0.038),靠近外侧者较内侧者更易出现颈侧区淋巴结转移(93.7% vs. 81.4%,P=0.049)。超声检查判定Ⅱ、Ⅲ、Ⅳ、Ⅴ区淋巴结转移的敏感度分别为43.9%、85.3%、85.7%、14.3%;特异度为91.4%、57.6%、35.1%、99.1%。超声预测Ⅲ、Ⅳ区淋巴结转移敏感度较高,Ⅱ、Ⅴ区淋巴结转移特异度较高。结论 癌灶位置与甲状腺微小癌颈侧区淋巴结转移密切相关,超声可为临床确定颈侧区淋巴结的清扫范围提供依据。 相似文献
37.
舌癌患者手术及放化疗后会出现构音障碍、吞咽困难、口腔黏膜炎、口干、营养不良等并发症,使患者生存质量下降,甚至导致肿瘤的复发转移,影响生存期,单一方法往往顾此失彼。依托于中国中医科学院西苑医院肿瘤康复基地,杨宇飞教授在国内外调研考察基础上,结合中国国情,构建了一种“门诊多学科肿瘤康复模式”,在舌癌康复方面,以患者为中心,以中医肿瘤内科为主导,多学科共同参与,结合康复科、口腔科、营养科、药剂科等各科优势,形成全程个体化规范序贯康复方案,对患者及早进行康复,在放疗前进行预防性干预尤其重要,使患者能够快速缓解手术和放疗的不良反应,患者获益明显。现取两个典型案例总结其舌癌多学科康复的经验,以期为舌癌的康复提供借鉴。 相似文献
38.
Shafqat R. Chaudhry Ilana S. Lendvai Sajjad Muhammad Philipp Westhofen Johannes Kruppenbacher Lukas Scheef Henning Boecker Dirk Scheele Rene Hurlemann Thomas M. Kinfe 《Brain stimulation》2019,12(3):643-651
Objective
To assay peripheral inter-ictal cytokine serum levels and possible relations with non-invasive vagus nerve stimulation (nVNS) responsiveness in migraineurs.Methods
This double-blinded, sham-controlled study enrolled 48 subjects and measured headache severity, frequency [headache days/month, number of total and mild/moderate/severe classified attacks/month], functional state [sleep, mood, body weight, migraine-associated disability] and serum levels of inflammatory markers [inter-ictal] using enzyme-linked immunoassays at baseline and after 2 months of adjunctive nVNS compared to sham stimulation and suitably matched controls.Results
No significant differences were observed at baseline and after 2 months for headache severity, total attacks/month, headache days/month and functional outcome [sleep, mood, disability] between verum and sham nVNS. However, the number of severe attacks/month significantly decreased in the verum nVNS group and circulating pro-inflammatory IL-1β was elevated significantly in the sham group compared to nVNS. Levels of anti-inflammatory IL-10 were significantly higher at baseline in both groups compared to healthy controls, but not at 2 months follow-up [p?<?0.05]. Concentrations of high-mobility group box-1 (HMGB-1), IL-6, tumor-necrosis factor-α (TNF-α), leptin, adiponectin, ghrelin remained unchanged [p?>?0.05]. No severe device-/stimulation-related adverse events occurred.Conclusion
2 months of adjunctive cervical nVNS significantly declined the number of severe attacks/month. Pro-inflammatory IL-1β plasma levels [inter-ictal] were higher in sham-treated migraine patients compared to verum nVNS. However, pro- [IL-6, HMGB-1, TNF-α, leptin] and anti-inflammatory [IL-10, adiponectin, ghrelin] mediators did not differ statistically. Profiling of neuroinflammatory circuits in migraine to predict nVNS responsiveness remains an experimental approach, which may be biased by pre-analytic variables warranting large-scale biobank-based systematic investigations [omics]. 相似文献39.
40.
Toshiro Hara Rony Chanoch-Myers Nathan D. Mathewson Chad Myskiw Lyla Atta Lillian Bussema Stephen W. Eichhorn Alissa C. Greenwald Gabriela S. Kinker Christopher Rodman L. Nicolas Gonzalez Castro Hiroaki Wakimoto Orit Rozenblatt-Rosen Xiaowei Zhuang Jean Fan Tony Hunter Inder M. Verma Kai W. Wucherpfennig Itay Tirosh 《Cancer cell》2021,39(6):779-792.e11
- Download : Download high-res image (228KB)
- Download : Download full-size image