分子吸附再循环系统对冠心病并发重度脓毒症患者心率和动脉压的影响

目的研究分子吸附再循环系统(MARS)对冠心病并发重度脓毒症患者心率和动脉压的影响.方法对2002年11月至2004年2月在ICU治疗的冠心病并发重度脓毒症患者所进行的12次床边MARS治疗有关资料进行回顾性分析和探讨.结果MARS治疗4 h后患者心率显著减慢,收缩压、舒张压和平均动脉压明显升高.结论MARS可改善MODS患者血流动力学指标.     

Ungewöhnliche Strahlenreaktion nach Röntgenweichstrahltherapie bei einer Patientin mit Pemphigus vulgaris

Zusammenfassung Bei einer 71j?hrigen Frau trat nach R?ntgenweichstrahltherapie an der Nase (Gesamtdosis 28 Gy, Gewebehalbwerttiefe 10,5–11,5 mm) eine ausgepr?gte Strahlenerosion auf. Diese zeigte 5 Wochen nach Ende der Bestrahlung noch keine Tendenz zur Abheilung. Ursache dieses ungew?hnlichen Verlaufes war ein gleichzeitig bestehender Pemphigus vulgaris. Dieser hatte sich nach der Strahlentherapie, vermutlich als Folge einer Freisetzung epidermaler Antigene, verschlimmert. Da? der Pemphigus in diesem Fall durch die Bestrahlung ausgel?st wurde – wie mehrfach in der Literatur berichtet – ist unwahrscheinlich, aber nicht sicher auszuschlie?en. Eingegangen am 11. April 1994 Angenommen am 10. Juni 1994     

内毒素核心糖脂单克隆抗体的血清学反应性及保护作用的初步研究

以S.minnesota R595菌为免疫原,通过细胞融合获得8株分泌抗核心糖脂单抗的杂交瘤细胞系。对其中的两株代表性单抗2D6E7和3H4 2F7的血清学反应性以及在小鼠Hb/Mu腹腔感染模型中的保护作用进行了初步研究。菌体吸收试验和间接免疫荧光试验(ⅡF)表明,单抗能与多种革兰氏阴性杆菌(GNB)产生交叉反应,并且光滑型GNB的煮沸菌体荧光染色呈阳性,活菌染色呈阴性。保护性试验结果表明,3H4 2F7单抗能显著提高S.minnesota(野生菌株),鼠伤寒杆菌和E.Coli等光滑型GNB攻击的小鼠存活率(P<0.05),显示出抗核心糖脂单抗的良好交叉保护作用。若攻击前、后2h或攻击同时输入单抗3H4 2F7,对光滑型GNB的感染均有明显保护效果(P<0.05);2D6 E7单抗未表现有保护活性。     

职业性接触苯、甲苯、二甲苯对子代行为影响的初步探讨

为探讨职业性接触苯、甲苯、二甲苯对子代行为的影响，以４６名父母生育期接触苯、甲苯、二甲苯的儿童为暴露组；抽取与暴露组同年龄、同性别、同班级、其父母无任何职业有害因素接触史的５８名儿童为对照组，用ＷＩＣＳ－Ｒ（韦克斯勒儿童智力量表）对研究对象进行智力测验，用ＮＢ－Ｉ型视运动反应仪测试视简单反应时。结果显示，接触组各智力测验的得分均低于对照组，视反应时指标慢于对照组，差异有显著意义；进一步的分层分析结果显示，母接触组的各项得分均低于对照组，而父接触组的各项得分与对照组之间差异无显著意义。     

Mechanisms of pinacidil-induced vasodilatation

The mechanism of the vasodilator effect of pinacidil was examined. Pinacidil (0.1–100 μM) inhibited the increases in cytosolic Ca²⁺ ([Ca²⁺]_i) and muscle tension due to norepinephrine in rat aorta. In contrast, a Ca²⁺ channel blocker, verapamil, inhibited the norepinephrine-stimulated [Ca²⁺]_i more strongly than the contraction. Higher concentrations of pinacidil (3–100 μM) inhibited the verapamil-insensitive portion of the contraction and [Ca²⁺]_i. An inhibitor of ATP-sensitive K⁺ channels, glibenclamide, antagonized the inhibitory effect of low concentrations ( 10 pM) of pinacidol. Pinacidil did not change the contraction induced by Ca²⁺ in vascular smooth muscle permeabilized with Staphylococcus aureus -toxin. Norepinephrine (in the presence of GTP), 12-deoxyphorbol 13-isobutyrate (in the absence of GTP), and treatment with GTP_γS potentiated the contraction of permeabilized smooth muscle induced by the addition of Ca²⁺. Pinacidil (100 μM) inhibited the potentiation due to GTP_γS or noepinephrine but not to phorbol ester. These results suggest that pinacidil has dual effects on vascular smooth muscle contraction. At lower concentrations (>0.1 μM), it decreases [Ca²⁺]_i, possibly by activating ATP-sensitive K+ channels. At higher concentrations (> 3 μM), it may additionally inhibit the receptor-mediated, GTP-binding protein-coupled phosphatidyl inositol turnover.     

神经系统疾病患者血小板参数的变化及临床意义

目的 探讨神经系统疾病患者血小板参数的变化。方法 测定神经系统疾病患者血小板数(PLT)和平均血小板体积(MPV)，并与对照组作比较。结果 与对照组比较，脑梗死、椎-基底动脉供血不足患者PLT明显减少，MPV明显增大；脑出血组MPV、PLT均减少。结论 血小板参数的变化对神经系统疾病的诊断、预防和治疗有重要的参考价值。     

Distribution of calbindin D-28K and parvalbumin immunoreactivities in the nucleus olfactorius anterior of the rat

The distributions of calbindin D-28K (CaBP) and parvalbumin (PV) in the rat nucleus olfactorius anterior (NOA) were described using monoclonal antibodies and the avidin-biotin-peroxidase method. The NOA showed a high immunoreactivity for CaBP, with a rostrocaudal increase in the positive neurons and fibres. Pars externa (NOAe) was the only subdivision which showed a low CaBP immunostaining. PV-positive elements were less abundant than those CaBP immunostained. The main difference in the distributions for both proteins was observed in the pars medialis which was practically PV negative. PV- and CaBP-stained neurons showed similar morphologies in the subdivisions where they were present. In NOAe, we observed a characteristic PV- and CaBP-positive neuronal type, with an oriented dendritic pattern. Transition areas were clearly observable in both CaBP- and PV-labelled sections.     

北京、广州、上海城市居民营养知识、态度、行为的调查

对北京、广州和上海三大城市随机抽取的９６５名年龄在２０～５０岁的城市居民进行有关营养知识、态度和行为（Ｋ－Ａ－Ｐ）的调查。结果显示，三地区调查对象的营养知识水平不高。营养知识的得分与其自身受教育程度有相关性（ｒ＝０．３０１１，Ｐ＜０．０１）。年龄在３５岁以上的对象，营养知识的得分高于年轻人；三地区调查对象对营养知识的获取，合理的膳食模式，卫生的饮食习惯均持有积极、肯定的态度。食物消费频度调查结果表明，米／面、肉／禽、蔬菜、水果、奶及奶制品的消费量较高。此外，８９．５％，７８．８％和４７．８％的调查对象分别选择报纸、电视、广播作为其主要营养信息来源。本次调查为将来的营养宣教的内容和方法提供依据。     

Aktuelle und effektive bildgebende Diagnostik von Sprunggelenk und Fuß

Projection radiographic techniques have been used in a standardized manner for decades for the diagnosis of conditions of the foot and ankle; the indications for them and the pattern of findings useful in the initial diagnosis and monitoring of the course are generally known to clinical radiology staff. Computed tomography has been introduced as an extension of the basic procedures performed for diagnosis in the ankle and the hindfoot. In the case of complex fractures, however, specialist experience is essential. CT is an easily accessible investigative procedure and is meanwhile economical and very powerful. Magnetic resonance imaging supplements the range of investigations in special cases when there are particular problems. Microfractures, findings indicative of inflammation and/or dystrophy and, in particular questions concerning the musculoligamentous support system are the situations in which such investigations are needed. Ultrasound has an additive value vis-à-vis magnetic resonance imaging and is an easily accessible and highly effective examination procedure both for the primary diagnosis and for serial monitoring. Financial constraints in the healthcare sector are increasingly limiting purely medical indications. Regardless of this development, the retention of projection radiography, computer tomography, and magnetic resonance imaging must be demanded for the initial diagnosis in the care of foot and ankle injuries. The earliest possible implementation of all these techniques for the initial diagnosis is the first step towards effective treatment. Cafrefully chosen and, if appropriate, complementary strategies are needed for monitoring of the course and for assessment.