全文获取类型
收费全文 | 118044篇 |
免费 | 7202篇 |
国内免费 | 2630篇 |
专业分类
耳鼻咽喉 | 1122篇 |
儿科学 | 3710篇 |
妇产科学 | 1751篇 |
基础医学 | 7198篇 |
口腔科学 | 1250篇 |
临床医学 | 14829篇 |
内科学 | 27137篇 |
皮肤病学 | 552篇 |
神经病学 | 4928篇 |
特种医学 | 8164篇 |
外国民族医学 | 5篇 |
外科学 | 15876篇 |
综合类 | 18280篇 |
现状与发展 | 4篇 |
预防医学 | 7886篇 |
眼科学 | 1216篇 |
药学 | 7865篇 |
85篇 | |
中国医学 | 3282篇 |
肿瘤学 | 2736篇 |
出版年
2024年 | 269篇 |
2023年 | 2023篇 |
2022年 | 4142篇 |
2021年 | 5372篇 |
2020年 | 4716篇 |
2019年 | 4207篇 |
2018年 | 4226篇 |
2017年 | 3644篇 |
2016年 | 3744篇 |
2015年 | 3834篇 |
2014年 | 8165篇 |
2013年 | 7662篇 |
2012年 | 6806篇 |
2011年 | 7434篇 |
2010年 | 6233篇 |
2009年 | 6127篇 |
2008年 | 6081篇 |
2007年 | 6263篇 |
2006年 | 5376篇 |
2005年 | 4573篇 |
2004年 | 3631篇 |
2003年 | 3055篇 |
2002年 | 2419篇 |
2001年 | 2335篇 |
2000年 | 1769篇 |
1999年 | 1611篇 |
1998年 | 1470篇 |
1997年 | 1372篇 |
1996年 | 1042篇 |
1995年 | 1097篇 |
1994年 | 907篇 |
1993年 | 766篇 |
1992年 | 730篇 |
1991年 | 597篇 |
1990年 | 530篇 |
1989年 | 459篇 |
1988年 | 425篇 |
1987年 | 378篇 |
1986年 | 302篇 |
1985年 | 372篇 |
1984年 | 338篇 |
1983年 | 177篇 |
1982年 | 264篇 |
1981年 | 202篇 |
1980年 | 173篇 |
1979年 | 153篇 |
1978年 | 123篇 |
1977年 | 87篇 |
1976年 | 79篇 |
1975年 | 34篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
52.
The initial management of bladder outflow obstruction typically related to benign prostatic hyperplasia (BPH) falls to a large extent within the remit of general practice. Referral onwards to secondary care typically arises following the failure to respond to conservative measures or when complications have supervened; the most significant of which is urinary retention. In the hospital setting, anaesthesia, constipation and immobility are the common precipitants. What follows is a practical guide to the management of these situations and provides an overview of the conservative, medical, minimally invasive and surgical treatments available. 相似文献
53.
Could non-HDL-cholesterol be a better marker of atherogenic dyslipidemia in obstructive sleep apnea?
《Sleep medicine》2021
Background/objectiveObstructive sleep apnea (OSA) is independently associated with dyslipidemia, a surrogate marker of atherosclerosis. Low-density lipoprotein (LDL)-cholesterol is accepted as a major independent risk factor for cardiovascular disease. However, non-high-density lipoprotein (HDL)-cholesterol is a better marker of atherogenic dyslipidemia and recommended as a target of lipid lowering therapy. We aimed to assess the prevalence of atherogenic dyslipidemia, and relationship between OSA severity and serum LDL-cholesterol and non-HDL cholesterol levels in OSA patients.MethodsWe retrospectively evaluated treatment naïve 2361 subjects admitted to the sleep laboratory of a university hospital for polysomnography. All subjects’ lipid profile including total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, and non-HDL-cholesterol were measured.ResultsOut of 2361 patients (mean age 49.6 ± 11.9 years; 68.9% male, apnea-hypopnea index 36.6 ± 28.4/h), 185 (7.8%) had no OSA and 2176 (92.2%) had OSA. Atherogenic dyslipidemia prevalence was high (57–66%) in OSA patients, and especially increased in severe OSA compared to other groups (p < 0.05). Though total and LDL-cholesterol did not differ between those with and without OSA, non-HDL-cholesterol (p = 0.020), and triglycerides (p = 0.001) were higher and HDL-cholesterol levels (p = 0.018) were lower in OSA patients than non-OSA. Non-HDL-cholesterol was significantly correlated with OSA severity (p < 0.001) and hypoxia parameters (p < 0.01), whereas LDL-cholesterol showed no correlation.ConclusionsAtherogenic dyslipidemia is highly prevalent and non-HDL-cholesterol levels are significantly increased, predominantly in severe OSA patients. Non-HDL-cholesterol but not LDL-cholesterol, is significantly correlated with OSA severity and hypoxia parameters. Therefore, it could be better to use non-HDL-cholesterol, which is a guideline recommended target of lipid therapy, as a marker of atherosclerotic cardiovascular risk in OSA patients. 相似文献
54.
Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease
Abhinav Sharma Adrian Coles Nishant K. Sekaran Neha J. Pagidipati Michael T. Lu Daniel B. Mark Kerry L. Lee Hussein R. Al-Khalidi Udo Hoffmann Pamela S. Douglas 《Journal of the American College of Cardiology》2019,73(8):893-902
Background
The optimal noninvasive test (NIT) for patients with diabetes and stable symptoms of coronary artery disease (CAD) is unknown.Objectives
The purpose of this study was to assess whether a diagnostic strategy based on coronary computed tomographic angiography (CTA) is superior to functional stress testing in reducing adverse cardiovascular (CV) outcomes (CV death or myocardial infarction [MI]) among symptomatic patients with diabetes.Methods
PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) was a randomized trial evaluating an initial strategy of CTA versus functional testing in stable outpatients with symptoms suggestive of CAD. The study compared CV outcomes in patients with diabetes (n = 1,908 [21%]) and without diabetes (n = 7,058 [79%]) based on their randomization to CTA or functional testing.Results
Patients with diabetes (vs. without) were similar in age (median 61 years vs. 60 years) and sex (female 54% vs. 52%) but had a greater burden of CV comorbidities. Patients with diabetes who underwent CTA had a lower risk of CV death/MI compared with functional stress testing (CTA: 1.1% [10 of 936] vs. stress testing: 2.6% [25 of 972]; adjusted hazard ratio: 0.38; 95% confidence interval: 0.18 to 0.79; p = 0.01). There was no significant difference in nondiabetic patients (CTA: 1.4% [50 of 3,564] vs. stress testing: 1.3% [45 of 3,494]; adjusted hazard ratio: 1.03; 95% confidence interval: 0.69 to 1.54; p = 0.887; interaction term for diabetes p value = 0.02).Conclusions
In diabetic patients presenting with stable chest pain, a CTA strategy resulted in fewer adverse CV outcomes than a functional testing strategy. CTA may be considered as the initial diagnostic strategy in this subgroup. (PROspective Multicenter Imaging Study for Evaluation of Chest Pain [PROMISE]; NCT01174550) 相似文献55.
56.
目的:探讨2型糖尿病(T2DM)患者不同脂质参数与糖尿病肾病(DKD)发生的相关性。方法:检测226例T2DM患者血清TC、TG、LDL-C、HDL-C水平及相关生化指标,计算血浆致动脉硬化指数(AIP)以及脂质三角相关指标(TC/HDL-C、TG/HDL-C、LDL-C/HDL-C)。根据DKD临床诊断标准和Mogensen分期标准分为:Ⅰ~Ⅱ期组136例,Ⅲ期组55例,Ⅳ~Ⅴ期组35例。应用多因素logistic回归分析不同脂质参数与DKD发生的关系。结果:与Ⅰ~Ⅱ期组相比,随着DKD分期加重,TC、TG、LDL-C、LDL-C/HDL-C、AIP水平明显增高(P<0.01)。LDL-C/HDL-C和AIP与24 h尿蛋白水平呈正相关(r=0.724;r=0.769,均P<0.05)。LDL-C/HDL-C和AIP是T2DM合并DKD患者的独立预测因子(P=0.002;P=0.004)。结论:LDL-C/HDL-C和AIP对T2DM合并DKD病情进展有较高的预测价值,可为临床诊治提供参考。 相似文献
57.
目的 了解2009-2019年西安市肺结核的流行特征及治疗转归情况,为完善西安市肺结核防治策略提供依据。方法 收集2009-2019年《传染病信息管理系统》中登记的肺结核患者病案信息数据,通过描述性研究方法对肺结核流行病学特征和治疗转归情况进行分析。结果 2009-2019年间西安市肺结核年平均发病率为49.06/10万。郊县、郊区、城区肺结核年平均发病率分别为54.13/10万、47.46/10万和46.19/10万;男性发病率是女性的1.85倍。职业分布排在前5位的为农民(47.48%),家政、家务及待业(14.65%),离退人员(9.55%),学生(8.63%)和工人(5.23%)。利福平敏感或耐药性未知患者的成功治疗率平均为98.03%,利福平耐药患者治疗成功率为51.47%。结论 西安市近年来肺结核发病率和治疗率呈增长趋势,利福平耐药患者治疗成功率较低,要加强对重点人群的健康促进工作,加大肺结核发现力度及患者治疗管理工作。 相似文献
58.
59.
60.