全文获取类型
收费全文 | 36388篇 |
免费 | 2995篇 |
国内免费 | 1037篇 |
专业分类
耳鼻咽喉 | 771篇 |
儿科学 | 634篇 |
妇产科学 | 530篇 |
基础医学 | 3355篇 |
口腔科学 | 693篇 |
临床医学 | 3768篇 |
内科学 | 5188篇 |
皮肤病学 | 396篇 |
神经病学 | 2537篇 |
特种医学 | 1321篇 |
外国民族医学 | 17篇 |
外科学 | 6142篇 |
综合类 | 4041篇 |
现状与发展 | 4篇 |
预防医学 | 1751篇 |
眼科学 | 1280篇 |
药学 | 2067篇 |
13篇 | |
中国医学 | 739篇 |
肿瘤学 | 5173篇 |
出版年
2024年 | 104篇 |
2023年 | 758篇 |
2022年 | 1280篇 |
2021年 | 1703篇 |
2020年 | 1565篇 |
2019年 | 1493篇 |
2018年 | 1413篇 |
2017年 | 1278篇 |
2016年 | 1335篇 |
2015年 | 1306篇 |
2014年 | 2551篇 |
2013年 | 2320篇 |
2012年 | 2163篇 |
2011年 | 2350篇 |
2010年 | 1817篇 |
2009年 | 1784篇 |
2008年 | 1815篇 |
2007年 | 1795篇 |
2006年 | 1516篇 |
2005年 | 1261篇 |
2004年 | 1130篇 |
2003年 | 952篇 |
2002年 | 791篇 |
2001年 | 650篇 |
2000年 | 513篇 |
1999年 | 495篇 |
1998年 | 435篇 |
1997年 | 370篇 |
1996年 | 307篇 |
1995年 | 270篇 |
1994年 | 303篇 |
1993年 | 251篇 |
1992年 | 220篇 |
1991年 | 224篇 |
1990年 | 173篇 |
1989年 | 143篇 |
1988年 | 139篇 |
1987年 | 143篇 |
1986年 | 148篇 |
1985年 | 221篇 |
1984年 | 178篇 |
1983年 | 132篇 |
1982年 | 139篇 |
1981年 | 114篇 |
1980年 | 95篇 |
1979年 | 72篇 |
1978年 | 63篇 |
1977年 | 58篇 |
1976年 | 35篇 |
1975年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
K. OKAMURA I. KOBAYASHI K. MATSUO T. KIYOSHIMA K. YAMAMOTO A. MIYOSHI & H. SAKAI 《Histopathology》1997,31(6):540-548
Aims:
The purpose of this study is to examine the relationship between immunohistochemical localization of cathepsin D (CD), proliferating cell nuclear antigen (PCNA) and epidermal growth factor receptor (EGF-R) in 65 cases of breast carcinoma in Japanese women and traditional prognostic factors such as histological grade, lymph node status, mitotic rate and clinical stage, in order to possibly identify some indicator(s) that may be specifically associated with prognosis.
Methods and results:
Serial sections of 5-μm thick were cut from the archival formalin-fixed, paraffin-embedded tissue blocks, and processed for CD, PCNA and EGF-R immunostaining. The results were analysed by computer-based image analysis system. All samples showed a positive immunoreaction for cathepsin D in both the parenchyma and stroma. However, the staining area and intensity varied from cell to cell in the parenchyma and stroma as well as among samples. Subsequently, the evaluation of immunostaining for CD was separately performed in both the parenchyma and stroma (CDpar and CDstr, respectively) and the combination of both components (CDtotal). PCNA and EGF-R showed positive immunostaining almost exclusively in the parenchymal component of the carcinoma tissue specimens. CDtotal significantly correlated with the histological grade, PCNA index (PI), mitotic rate (MR), EGF-R and lymph node metastasis. Significant correlation was also demonstrated between CDpar and the histological grade, EGF-R and lymph node metastasis, or between CDstr and MR, EGF-R and lymph node metastasis. EGF-R correlated highly with the histological grade, MR score, lymph node metastases and recurrence-free survival.
Conclusions:
Both the CD parameters and EGF-R are valuable indicators for predicting the biological behaviour of human breast carcinoma. 相似文献
22.
通过半年对35名7~12岁轻度碘缺乏病儿童进行补碘,并与同龄、同地的正常儿童和缺碘未补碘儿童进行比较,以观察补碘对儿童脑功能及生长发育的影响。结果发现:①补碘可使儿童碘营养状况恢复正常,尿碘值由(83.2±3.5)μg/L上升到(162.2±1.6)μg/L,血清T4、FT4I和rT3:也与正常儿童一致而与未补碘儿童有显著性差异(P<0.05).②轻度碘缺乏病儿童智商低于正常儿童(P<0.01),补碘在一定程度上改善其智商水平。③轻度碘缺乏病及补碘未能明显影响儿童的生长发育,可能与儿童总营养水平较差有关。 相似文献
23.
U. Meyding-Lamadé K. Rieke D. Krieger W. Hacke Michael Forsting Klaus Sartor Christian Sommer 《Journal of neurology》1995,242(5):335-343
Acute ischaemia of the vertebrobasilar circulation leads to a variety of clinical manifestation and is mostly due to cardiogenic or artery-to-artery embolism. We describe four neurological emergency situations involving vertebrobasilar artery aclusion of other origins: basilar migraine, extrinsic compression by rheumatoid inflammatory tissue, generalized vasculitis in subacute rheumatic fever and basilar artery dissection. The differential diagnosis of acute vertebrobasilar artery occlusion may have an important impact on patient management. 相似文献
24.
Beatrix Tirkanits M.D. F.R.C.S.C. Rollin K. Daniel M.D. F.A.C.S. 《Aesthetic plastic surgery》1990,14(1):111-117
A new technique of forehead rhytidectomy is presented that combines the best features of the coronal incision with those of the anterior hairline incision. The plane of dissection is formed by an anterior subcutaneous plane dissecting a lateral subgaleal plane. This approach is particularly valuable in patients with high foreheads, severe static wrinkling, and asymmetrical eyebrows.Presented in part at the Annual Meeting of the American Society of Aesthetic Plastic Surgeons, Boston, MA, 1984 相似文献
25.
26.
27.
Hyun Jik Kim Jinna Kim Joo-Heon Yoon 《European archives of oto-rhino-laryngology》2006,263(8):778-782
Olfactory neuroblastoma is a rare, malignant neoplasm arising from the olfactory epithelium. It has an aggressive biological behavior that is characterized by local recurrence, atypical distant metastasis, and poor long-term prognosis. The incidence of cervical lymph node metastasis in olfactory neuroblastoma is variable, and treatment modalities are controversial. Moreover, few reports have been published concerning retropharyngeal lymph node metastasis from olfactory neuroblastoma. We present two cases of olfactory neuroblastoma with retropharyngeal lymph node metastasis. In addition, we provided a review of the current literature regarding olfactory neuroblastoma and retropharyngeal lymph node metastasis from olfactory neuroblastoma. 相似文献
28.
在53只乌拉坦麻醉家兔身上,观察到延髓孤束核(NTS)区注射γ-氨基丁酸(GABA)使血压显著下降,安定(DZ)有相似的降压效应,荷包牡丹碱(BIC)和印防己毒素(PIC)则使血压升高;促甲状腺素释放激素(TRH)和甲硫脑啡肽(MTP)对血压无明显影响;延髓的另一些区域应用GABA等药物后血压变化不明显;提示GABA能神经递质系统参与心血管活动的抑制性中枢调节,NTS区是其作用部位之一。 相似文献
29.
30.
Yutaka Saito Takahisa Matsuda Tsuyoshi Kikuchi Hisatomo Ikehara Toshio Uraoka 《Digestive endoscopy》2007,19(Z1):S34-S39
Endoscopic submucosal dissection (ESD) for colorectal cancer is not widely accepted because of its technical difficulty and the risk of perforation. In addition, the risk of peritonitis cannot be completely eliminated even if a perforation is closed successfully. Reported here are two cases of early colon cancer in which the patients sustained iatrogenic perforations of the ascending colon during conventional endoscopic mucosal resection and of the sigmoid colon during ESD, respectively, requiring abdominal decompression with an 18 G Medicut needle. Both of these perforations were successfully treated by endoscopic clipping. In conclusion, conservative medical management may be possible in patients who have undergone successful closure of colonic perforations using endoscopic clipping. In order to perform immediate endoscopic closure, abdominal decompression has been useful to decrease patient discomfort and colonic lumen collapse. Now, CO2 insufflation is being used effectively for the prevention of pneumoperitoneum. 相似文献