全文获取类型
收费全文 | 10952篇 |
免费 | 1301篇 |
国内免费 | 649篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 77篇 |
妇产科学 | 43篇 |
基础医学 | 991篇 |
口腔科学 | 223篇 |
临床医学 | 666篇 |
内科学 | 1197篇 |
皮肤病学 | 85篇 |
神经病学 | 432篇 |
特种医学 | 210篇 |
外国民族医学 | 4篇 |
外科学 | 625篇 |
综合类 | 2191篇 |
现状与发展 | 3篇 |
预防医学 | 1268篇 |
眼科学 | 170篇 |
药学 | 2063篇 |
7篇 | |
中国医学 | 2211篇 |
肿瘤学 | 399篇 |
出版年
2024年 | 121篇 |
2023年 | 352篇 |
2022年 | 791篇 |
2021年 | 885篇 |
2020年 | 716篇 |
2019年 | 516篇 |
2018年 | 423篇 |
2017年 | 455篇 |
2016年 | 423篇 |
2015年 | 408篇 |
2014年 | 693篇 |
2013年 | 742篇 |
2012年 | 735篇 |
2011年 | 759篇 |
2010年 | 563篇 |
2009年 | 497篇 |
2008年 | 491篇 |
2007年 | 502篇 |
2006年 | 383篇 |
2005年 | 332篇 |
2004年 | 275篇 |
2003年 | 249篇 |
2002年 | 202篇 |
2001年 | 134篇 |
2000年 | 138篇 |
1999年 | 98篇 |
1998年 | 78篇 |
1997年 | 85篇 |
1996年 | 66篇 |
1995年 | 71篇 |
1994年 | 63篇 |
1993年 | 58篇 |
1992年 | 60篇 |
1991年 | 44篇 |
1990年 | 53篇 |
1989年 | 35篇 |
1988年 | 44篇 |
1987年 | 33篇 |
1986年 | 38篇 |
1985年 | 43篇 |
1984年 | 35篇 |
1983年 | 24篇 |
1982年 | 32篇 |
1981年 | 26篇 |
1980年 | 18篇 |
1979年 | 24篇 |
1978年 | 20篇 |
1977年 | 11篇 |
1976年 | 17篇 |
1975年 | 15篇 |
排序方式: 共有10000条查询结果,搜索用时 218 毫秒
41.
M. Fujioka M.D. K. Okuchi S. Miyamoto T. Sakaki S. Tsunoda S. Iwasaki 《Acta neurochirurgica》1994,131(3-4):265-269
Summary The authors describe a 66-year-old man with progressive gait disturbance caused by bilateral organized chronic subdural haematomas. The characteristics of these lesions on magnetic resonance (MR) images have not yet been clarified. The organized haematoma in our patient exhibited slight hypo-intensity on T 1-weighted MR images and marked hypo-intensity on T 2-weighted MR images obtained at 1.5 T. Preoperative MR imaging may give us useful information about surgical strategy in the case of chronic subdural haematoma with an unusual appearance on computed tomographic (CT) scans. 相似文献
42.
43.
The ionic mechanisms of the effect of extracellularly ejected recombinant human tumor necrosis factor-alpha (rhTNF-alpha) on the membrane of identified neurons R9 and R10 of Aplysia kurodai was investigated with conventional voltage-clamp, micropressure ejection, and ion substitution techniques. Micropressure-ejected rhTNF caused a marked hyperpolarization in the unclamped neuron. Clamping the same neuron at it resting potential level (-60 mV) and reejecting rhTNF-alpha with the same dose produced a slow outward current [Io (TNF)] associated with a decrease in input membrane conductance. Io (TNF) was decreased by depolarization and increased by hyperpolarization. The extrapolated reversal potential of Io (TNF) was approximately +10 mV. Ion substitution and pharmacological experiments suggest that Io (TNF) in identified neurons R9 and R10 of A. kurodai is due to a decreased Na+ conductance but not due to an activation of the Na(+)-K+ pump. Our results demonstrate that the immunomodulator TNF can act directly on the nervous system as well as on the immune system. 相似文献
44.
精神分裂症患者心理防御机制与人格特征的相关性分析 总被引:7,自引:1,他引:6
目的 探讨精神分裂症患者心理防御方式和人格特片的特点及二者的相关性。方法 分别运用防御方式问卷 (DSQ)和艾森克个性问卷 (EPQ)对 10 1名精神分裂症患者和 30例正常人群进行防御方式评定和人格测定。结果 与正常对照组相比 ,精神分裂症患者更多采用不成熟和中间型防御方式 (P <0 0 5 )。防御方式与人格特征存在着一定的关联性 (P <0 0 5 )。不成熟型防御方式和中间型防御机制与EPQ的精神质 (P)得分和神经质 (N)得分呈显著正相关 (P <0 0 1) ,成熟防御机制与内外向(E)得分呈显著正相关 (P <0 0 5 )。结论 精神分裂症患者更多地使用不成熟防御机制 ,存在病态人格 ,且者之间存在明显相关性 ,有关结果 ,对于探讨精神分裂症患者的病理心理机制和开展心理治疗有指导意义。 相似文献
45.
病理性近视眼的研究进展 总被引:5,自引:4,他引:1
通过复习近年来相关文献,对近视眼发生发展机制与形觉剥夺之间的关系进行综合评述。认为近视眼的发生及眼轴延长与形觉剥夺有一定关系,深入研究其相关机制,对近视眼的早期防治具有重要意义。 相似文献
46.
Vera S. Donnenberg Gilbert J. Burckart Albert D. Donnenberg 《Clinical and Applied Immunology Reviews》2003,4(1):15-30
P-glycoprotein (P-gp), a member of the adenosine triphosphate (ATP)-binding cassette (ABC) family of transporter molecules, is responsible for maintaining low intracellular concentrations of a variety of extracellular compounds and xenobiotics, and for transport of various intracellular molecules. Many drugs are P-gp substrates and intracellular concentrations of these agents may be critical for drug action. Experience in oncology indicates that repeated exposure to P-gp substrate cytotoxic drugs leads to the selection of drug-resistant tumor cells that overexpress P-gp. Since immunosuppressive agents such as cyclosporine, tacrolimus, sirolimus and corticosteroids are substrates for P-gp and since T-cells also express P-gp, it is conceivable that an analogous mechanism exits for therapy-resistant graft rejection. As will be discussed in this article, P-gp may interfere with the response to immunosuppressive therapy through several distinct mechanisms, and as such may represent an attractive therapeutic target. 相似文献
47.
浅析《内经》之闭经证治 总被引:1,自引:1,他引:0
收集了《内经》有关闭经方面的相关阐述从而探讨闭经的病因病机、诊断与治疗,并详细记述了《内经》对血滞经闭和血枯经闭这两类型经闭的不同治疗法度。 相似文献
48.
J. P. Neary T. P. Martin D. C. Reid R. Burnham H. A. Quinney 《European journal of applied physiology》1992,65(1):30-36
Summary The influence of tapering on the metabolic and performance parameters in endurance cyclists was investigated. Cyclists (n = 25) trained 5 days · week–1, 60 min·day–1, at 75–85% maximal oxygen consumption (VO2max) for 8 weeks and were then randomly assigned to a taper group: 4D (4 days;n = 7), 8D (8 days;n = 6), CON (control, 4 days rest;n = 6), NOTAPER (non-taper, continued training;n = 6). Muscle biopsy specimens taken before and after training and tapering were analysed for carnitine palmityltransferase (CPT), citrate synthase, ß-hydroxyacyl CoA dehydrogenase (HOAD), cytochrome oxidase (CYTOX), lactate dehydrogenase, glycogen and protein. Significant increases inVO2max (6%), a 60-min endurance cycle test (34.5%), oxidative enzymes (77–178%), glycogen (35%) and protein (34%) occurred following training. After the taper, HOAD and CPT decreased 25 % (P<0.05) and 26% respectively, in the CON. Post-taper CYTOX values were different (P<0.05) for 4D and 8D compared with CON. Muscle glycogen levels were increased (P<0.05) after tapering in the 4D, 8D and CON, but decreased in NOTAPER. Similarly, power output at ventilation threshold was significantly increased in the 4D (27.4 W) and 8D (27 W) groups, but decreased (22 W) in the NOTAPER. These findings suggest that tapering elicited a physiological adaptation by altering oxidative enzymes and muscle glycogen levels. Such an adaptation may influence endurance cycling during a laboratory performance test. 相似文献
49.
50.
施地瑞玛生理性海水鼻腔喷雾器治疗小儿干燥性鼻炎的临床观察 总被引:1,自引:0,他引:1
目的:探讨施地瑞玛生理性海水鼻腔喷雾器治疗小儿干燥性鼻炎的疗效。方法:将58例患儿随机分成2组,2组均不使用其他药物。治疗组给予施地瑞玛生理性海水鼻腔喷雾器喷鼻;对照组给予生理性盐水滴鼻液滴鼻,观察2组治疗前后症状、体征及有效率。结果:根据2组的主要症状、体征及疗效,治疗组优于对照组(P<0.05)。结论:生理性海水鼻腔喷雾器治疗小儿干燥性鼻炎,可以缩短病程,改善鼻腔功能,疗效确切,且使用安全、舒适、方便,可以作为治疗小儿干燥性鼻炎的理想药物。 相似文献