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71.
Preserved cortical asymmetry despite thinner cortex in children and adolescents with prenatal alcohol exposure and associated conditions
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Dongming Zhou Carmen Rasmussen Jacqueline Pei Gail Andrew James N. Reynolds Christian Beaulieu 《Human brain mapping》2018,39(1):72-88
Prenatal alcohol exposure (PAE) is associated with reduced overall brain volume. Although this has been reported consistently across studies, the status of cortical thickness after PAE is more variable. The cortex is asymmetric in typical controls, but it is unclear whether the left and right counter parts of the cortical gray matter are unevenly influenced in postpartum brain development after PAE. Brain MRI was acquired in a newly recruited sample of 157 participants (PAE: N = 78, 5.5–18.9 years, 40 females and controls: N = 79, 5.8–18.5 years, 44 females) across four Canadian sites in the NeuroDevNet project. The PAE group had other confounds such as psychiatric co‐morbidity, different living environment, and so on, not present in the control group. In agreement with previous studies, the volumes of all brain structures were reduced in PAE compared to controls, including gray and white matter of cerebrum and cerebellum, and all deep gray matter including the hippocampus, amygdala, thalamus, caudate, putamen, and pallidum. The PAE group showed reductions in global and regional cortical thickness, while the pattern and degree of cortical thickness asymmetry were preserved in PAE participants with the greatest rightward asymmetry in the lateral parietal lobe and the greatest leftward asymmetry in the lateral frontal cortex. This persistent asymmetry reflects that the homologous left and right cortical regions followed typical relative developmental patterns in the PAE group despite being thinner bilaterally than controls. Hum Brain Mapp 39:72–88, 2018. © 2017 Wiley Periodicals, Inc. 相似文献
72.
我国儿科铜绿假单胞菌耐药及其对策 总被引:2,自引:0,他引:2
黄敬孚 《中国实用儿科杂志》2010,25(1):22
<正>铜绿假单胞菌(PAE)俗称绿脓杆菌,1872年由Schreeter命名,为无芽孢端生单鞭毛革兰阴性小杆菌。该菌广泛分布在水、空气、土壤、医院环境及动物和人体的皮肤、呼吸道、肠道中,为条件致病菌。可通过水源、土壤、接 相似文献
73.
Leandro Cardarelli-Leite Andre M. de Assis Airton M. Moreira Alberto A. Antunes Giovanni G. Cerri Miguel Srougi Francisco C. Carnevale 《Journal of vascular and interventional radiology : JVIR》2019,30(2):228-232
Purpose
To compare the 12-month post-prostatic artery embolization (PAE) clinical outcomes of patients who were and were not taking 5-alpha-reductase inhibitors (5ARIs) at the time of PAE.Materials and Methods
A retrospective review was conducted of patients who underwent PAE from 2010 to 2017 due to lower urinary tract symptoms, secondary to benign prostatic hyperplasia (BPH). One hundred fifty-five patients were included and divided in 2 groups; these groups did not present statistically significant differences in their baseline characteristics—those taking 5ARIs (Y-5ARIs, n = 40) and those not taking 5ARIs (N-5ARIs, n = 115). International Prostate Symptom Score (IPSS), the sub-item Quality of Life (QoL), and the incidence of clinical failure were used as primary endpoints. Secondary endpoints included mean prostate volume reduction and mean peak flow rate (Qmax) improvement. Clinical failure or recurrence was defined as absence of symptomatic improvement (IPSS ≥ 8 or QoL ≥ 3) or the need for invasive BPH treatment (PAE or transurethral resection of the prostate) during the 12-month follow-up period.Results
After 12-month follow-up, IPSS, QoL, and prostatic volume were significantly lower compared to baseline in both groups, and Qmax showed a significant increase. No statistically significant differences were observed in outcomes between N-5ARIs and Y-5ARIs, and the clinical failure rate for both groups was approximately 20%.Conclusions
The use of 5ARIs did not show a detrimental effect on clinical outcomes of PAE, in either subjective (IPSS, QoL, and clinical failure) or objective (prostatic volume and Qmax) parameters. 相似文献74.
John S. DeMeritt Ethan Wajswol Anoop Wattamwar Andrew Osiason Tanya Chervoni-Knapp Stacy Zamudio 《Journal of vascular and interventional radiology : JVIR》2018,29(11):1595-1600.e9
Angiograms and cone-beam computed tomography scans of 36 consecutive prostate artery embolization patients (72 hemipelves) between October 2014 and February 2018 were reviewed. The hemipelves were classified according to the presence of dual central gland (CG) blood supply and the pattern of vascularization: Type 1 with a single CG blood supply (83.3%; n = 60); Type 2 with 2 independent CG arteries with overlapping territories (9.7%; n = 7); and Type 3 with 2 independent CG arteries with isolated territories (7%; n = 5). Up to 20% of pelvic sides may have more than 1 independent CG prostate artery that should be searched for during prostate artery embolization. 相似文献
75.
Sipan Mathevosian Adam N. Plotnik Justin P. McWilliams 《Journal of vascular and interventional radiology : JVIR》2019,30(11):1820-1823
Eight patients with giant prostatic enlargement > 200 mL and lower urinary tract symptoms who underwent bilateral prostatic artery embolization (PAE) were reviewed. Mean prostate volume decreased from 318.2 mL to 212.2 mL (P < .01). At 5-month mean follow-up, International Prostate Symptom Score decreased by 16.7 points (P < .05), and urinary quality of life improved by 3.0 points (P < .01). Three of 4 catheter-dependent patients no longer needed catheterization after the procedure. No major complications were encountered. Preliminary results suggest PAE is safe and effective in patients with giant prostatic enlargement > 200 mL. 相似文献
76.
目的:对比研究氟罗沙星(FLRX)与其它氟喹诺酮类药物对临床分离致病菌的体内外抗菌活性及抗生素后效应(PAE)。方法:应用琼脂平板稀释法测定最低抑菌浓度(MIC),微量稀释法测定血清杀菌效价(SBA),吸光度法测定PAE。结果:FlRX对金葡菌、大肠埃希菌、肺炎克雷伯菌、绿脓假单胞菌均具很强的体内外抗菌活性,与氧氟沙星(OFLX)相似,而强于洛美沙星(LFLX);FLRX对上述受试菌的峰时SBA与OFLX和LFLX相似,但谷时SBA多在1:1以上,高于OFLX和LFLX。FLRX无论对革兰阳性或阴性菌均具较长的PAE,呈显著的浓度依赖性,除金葡菌外,对其它受试菌的PAE均长于OFLX。结论:FLRX抗菌谱广,体内外抗菌活性强,具有较长时间的PAE,临床可采取每日1次给药方案治疗各类细菌感染。 相似文献
77.
目的 研究夫西地酸对临床分离的葡萄球菌的体外抗菌作用,为夫西地酸的临床合理应用提供依据.方法 采用琼脂二倍稀释法测定夫西地酸的最低抑菌浓度(MIC),以夫西地酸的MIC为基础,根据抗生素后效应理论,应用光密度法测定了夫西地酸对1株ATCC 29213、2株表面葡萄球菌和4株金黄色葡萄球菌(包括2株耐甲氧西林的金黄色葡萄球菌和2株甲氧西林敏感的金黄色葡萄球菌)的体外PAE.结果 87.7%的葡萄球菌对夫西地酸敏感,耐药菌主要为耐甲氧西林的凝固酶阴性葡萄球菌;夫西地酸对上述7株葡萄球菌的抗生素后效应(PAE)的范围为0.14~1.54 h.结论 夫西地酸对各种葡萄球菌,包括耐甲氧西林的金葡菌具有良好的抗菌作用;夫西地酸对葡萄球菌具有较短的PAE,且随药物浓度的不同,PAE也不一样. 相似文献
78.
Jhih-Wei Chen Ji Hoon Shin Teng-Fu Tsao Heung-Gyu Ko Hyun-Ki Yoon Ki-Chang Han Somrach Thamtorawat Bumsik Hong 《Journal of vascular and interventional radiology : JVIR》2017,28(2):295-301
Nine patients with advanced prostate cancer (stage T4) underwent prostatic arterial embolization (PAE) for refractory prostatic hematuria. Angiograms showed prostatic neovascularity in all cases, and complete PAE was achieved in 8 cases (89% technical success rate). Gross hematuria ceased after PAE in 6 cases, translating to a 67% clinical success rate. There were no PAE-related complications. At 3-month follow-up, 2 cases showed recurrent hematuria, 4 patients had died from PAE-unrelated etiologies, and only 3 patients survived and were without gross hematuria. PAE could represent an alternative option for patients with advanced prostate cancer to control hematuria. 相似文献
79.
80.
《Journal of vascular and interventional radiology : JVIR》2014,25(6):875-879
In 9 of 491 patients (1.8%) who underwent prostatic arterial embolization (PAE) for benign prostatic hyperplasia from March 2009–November 2013, prostatic arteries arose from the external iliac artery via an accessory obturator artery (AOA). Computed tomography angiography performed before the procedure identified the variant and allowed planning before the procedure. The nine AOAs were catheterized from a contralateral femoral approach. Bilateral PAE was technically successful in the nine patients. There was a mean decrease in international prostate symptom score of 6.5 points and a mean prostate volume reduction of 15.1% (mean follow-up, 4.8 mo) in the nine patients. 相似文献