Computed tomographic findings in cerebral toxoplasmosis in adults

The clinical and computerized tomographic (CT) findings in 10 patients with cerebral toxoplasmosis are reviewed. All patients with cerebral toxoplasmosis were homosexuals and/or intravenous drug users, and all patients had other manifestations of AIDS. Two presented with focal seizures, 4 presented with focal neurological deficit which progressively worsened, and 4 had evidence of diffuse neurological dysfunction (altered consciousness, generalized seizures). CT showed a single lesion in 3 patients and multiple lesions in 7 patients. Two patients had hypodense nonenhancing lesions(s). Eight patients had hypodense lesions with peripheral or nodular enhancement. The lesions were more commonly located in the cerebral hemispheres and subcortical gray matter nuclear masses (thalamus, basal ganglia). The finding of a hypodense lesion with a central slightly hyperdense noncalcified region that showed dense nodular homogeneous enhancement was quite characteristic of cerebral toxoplasmosis, but this pattern may also be seen in other neurological conditions including brain lymphomas.     

中国西部地区儿童甲状腺肿大率、尿碘、盐碘变异程度的分析

目的 研究影响或导致儿童甲状腺肿大率(甲肿率)、尿碘、盐碘三项指标变异程度的因素。方法 用设计效率(DEFF)作为评价变异程度的指标。结果 在西部12省中，儿童甲肿率的DEFF在3．0左右的有9个省，占75．0％；尿碘水平的DEFF在1．0～3．5之间的有6个省，占50．0％；合格碘盐食用率的DEFF有11省在3．0以上。有4个省加碘盐覆盖率的DEFF在3．0左右。结论 除了充分考虑非抽样因素对甲肿率、尿碘、盐碘三项指标变异程度的影响外，还应对西部监测中样本的数量作进一步的推算，使样本量这一影响指标变异程度的主要因素更加科学、合理，从而为全国的碘缺乏病监测工作提供科学依据。     

慢性胃炎结节状改变的临床研究

目的 研究萎缩性胃炎和结节性胃炎的结节状改变的特征.方法 在2004年4月至2005年3月之间,通过临床特征、内镜及病理结果,来对比分析胃镜检查中发现的慢性胃炎的结节状改变.结果 本次研究显示慢性胃炎的结节状改变分为结节类型A（结节性胃炎）和B（萎缩性胃炎的结节状改变）.结节性胃炎的胃镜下表现为结节具有大小均一、分布密集的特点,多发生于年轻女性,几乎都以上腹部疼痛为主诉,并且感染了幽门螺杆菌,病理检查有淋巴滤泡而没有萎缩和肠上皮化生.而萎缩性胃炎的结节类型B,胃镜下表现为结节大小不一、分布松散,多发生于50岁以上男性,主诉具有多样性的特点,并且幽门螺杆菌检测部分阴性,病理的结果发现有中、重度萎缩和肠上皮化生,而少有淋巴滤泡.结论 拥有结节状改变类型A的结节性胃炎是一种新的特殊胃炎,不同于萎缩性胃炎的结节状改变,应该引起重视.     

结节性甲状腺肿及其非典型结节与甲状腺癌细胞核DNA定量研究

作者对结节性甲状腺肿及其非典型结节与甲状腺癌细胞核直径、面积及 DNA 含量检测,发现核直径与面积的(?)和 S 为甲状腺癌组>非典型结节组>对照组(P<0.01);随着细胞增生异型程度的加重,核直径、面积及离散程度随之增加、DNA 含量也显著增加,显示Ⅲ级 DNA 含量细胞出现频率越高恶性的可能性就越大;同时发现各组细胞核不同 DNA 含量的核直径、面积均明显增加,与对照组相比差异生非常显著(P<0.01)。     

Graves病患者血清可溶性白介素2受体的探讨

对２８例Ｇｒａｖｅｓ病的可溶性白介素２受体（ｓＩＬ２Ｒ）和各种甲状腺激素以及甲状腺自身抗体治疗前后比较，并进行逐步回归，结果表明：治疗后Ｇｒａｖｅｓ病患者除ＴＳＨ外，各种甲状腺激素及甲状腺自身抗体显著降低（Ｐ＜００１），并对ｓＩＬ２Ｒ的上升与下降呈显著相关。     

三次抛物线配合方法在碘缺乏病区居民患病率分析中的应用

<正>在碘缺乏病区,居民甲状腺肿患病率在年鹅分布上的特征,可用二次抛物线加以描述[l].根握资料类型的不同,可选择更为适合的三次抛物线来描述.根据现场调查资料,本文采用三次抛物线方法进行配合,并将配合结果与二     

A novel variety of atypical pneumocystis carinii infection after long-term prophylactic pentamidine inhalation in an AIDS patient: large lower lobe pneumocystoma

Summary Atypical pulmonary manifestations of Pneumocystis carinii infection and fair numbers of extrapulmonary and disseminated infections have lately been documented in patients with human immunodeficiency virus infection treated prophylactically with inhalative pentamidine. We report the case of a 32-year-old homosexual patient who was assessed for complaints of night sweats, weight loss, and progressive malaise. The patient denied any respiratory tract symptoms such as cough, sputum production, pleuritic chest pain, or shortness of breath. Chest X-ray revealed two large round noncavitating lesions in the lower lobe of the right lung. Pneumocystomas were diagnosed by fine-needle aspiration. A 3-week course of intravenous high-dose cotrimoxazole resulted in amelioration of symptoms but no change in the radiographic appearance of the pulmonary lesions. Four months later the patient is alive and stable and is being treated with pentamidine inhalation of 300 mg per 2 weeks and two tablets of pyrimethamine sulfadoxine per week.Abbreviations PcP Pneumocystis carinii pneumonia - Pc Pneumocystis carinii - AIDS acquired immunodeficiency syndrome - HIV human immunodeficiency virus     

Reciprocal/dichotomic expression of vimentin and B cell differentiation antigens in Reed-Sternberg's cells

Summary An immunohistochemical study of 63 cases of Hodgkin's disease was undertaken using formalin-fixed paraffin embedded tissue sections. The antibodies used were against L26, LN-1, LN-2, EMA (epithelial membrane antigen), Leu-M1, Vimentin, UCHL-1, S-100, and lysozyme. Hodgkin's disease could be divided into three groups: the first group was LN-1+/L26+/vimentin-, the second LN-1-/L26+/vimentin+, and the third LN-1-/L26-/vimentin+). Sixteen cases of follicular lymphomas were also examined and were all positive for LN-1 and L26 and negative for vimentin. Thus the vimentin negativity of the first group, including 7 nodular lymphocyte-predominant cases, gives further evidence of their germinal center B-cell origin. Since vimentin is expressed mainly in the immature stage of B-lymphocytes, the second group of Hodgkin's disease may represent immature B-cell Hodgkin's disease. In the third group, vimentin was present in Reed-Sternberg's (RS) and Hodgkin's (H) cells in 45 of the 48 cases (92.5%). In none of 48 cases were these cells positive for S-100 or lysozyme, but strong vimentin-positivity still suggested monocytic or histiocytic origin. The results of our study suggest, at least, divergent origin of RS's and H's cells.     

误诊为肉瘤的结节性筋膜炎之临床病理研究

目的：探讨结节性筋膜炎被误诊为肉瘤的原因,方法观察７４例被误诊为肉瘤的结节性筋膜炎临床病理及免疫组化特点,其中对６２例采用ＡＢＣ、ＬＳＡＢ法行免疫组化染色。结果７４例病人临床表现均为良性经过,但镜下组织学极似肉瘤形态,６８例获随访,结果均存活,复发率不足１％,６２例做了免疫组织化学染色,梭形细胞Ｖｉｍｅｎｔｉｎ阳性,ＭＳＡ,ＳＭＡ和ＫＰ１部分病例阳性,Ｋｅｒａｔｉｎ、Ｓ－１００、Ｄｅｓｉｍｉｎ均为