聚丙烯／尼龙6原位复合材料的形态与表面,界面特性

以聚丙烯为基体、尼龙６为分散相共混得到分散相成纤的原位复合材料。显微形态观察发现在考察的浓度范围内微纤的直径基本与分散相含量无关。提高拉伸作用和增大剪切作用使微纤变细。当分散相含量越大，纤维数目越多时，水在复合材料表面的接触角越小，材料的吸水率越高。     

胆管癌细胞核形态学与其生物学行为的关系

本研究利用ＱＵＡＮＴＩＭＥＴ—９７０图象分析仪对２６例胆管癌细胞核形态学进行了测定。并探讨了胆管癌细胞核形态学与其ＴＮＭ分期、组织病理学分级、肿块大小、浸润性和淋巴转移等生物学行为的关系。研究结果表明：胆管癌细胞核内ＤＮＡ含量和异型性的大小可作为判断其预后的客观指标；胆管癌肿块的大小与其癌细胞核内ＤＮＡ含量成正比，且与ＤＮＡ分布有关；胆管癌细胞核的异型性和ＤＮＡ分布为探讨不同性别患者的胆管癌发病率提供了一个线索；胆管癌细胞核ＤＮＡ倍体与其术后生存率的关系尚需进一步研究。     

中药木香类的显微鉴定研究

对木香Aucklandia lappa Decne.及川木香属(Dolomiaea)植物共8种木香类药材的性状、组织造和粉末特征进行了鉴定研究,各种间有一定的区别。川木香属部分植物的根极度偏心生长,有的成木内韧皮部。     

Somatomedin activity in plasma from burned patients with observations on plasma cortisol

The somatomedin activity (SMA) was assayed in 108 plasma samples from 12 patients with burns which varied in surface area from 10 to 51 per cent. The plasma SMA was greatly reduced or eliminated within 2 days post burn and remained reduced for a period of 1–9 days. The activity then slowly increased in the patients who recovered. The duration of depression of SMA significantly correlated with the area of the burns and with the volume of fluids transfused relative to the patient's blood volume. Four patients died and their plasma had little or no SMA in the days, or weeks before death. The plasma cortisol concentrations were elevated in all but one patient within 2 days of burning and remained high for between 1 and 4 days.

By mixing plasma taken soon after burning with normal human serum it was shown that the low SMAs were unlikely to be due to an inhibitor(s) of somatomedins (SMs). Some of these plasmas lacked SMA, possibly due to the degradation of SMs and/or the binding of SMs to damaged tissues. Others showed ‘latent SMA’, suggesting that these plasmas lacked a ‘permissive agent(s)’ required for SMs to act on the cartilage.     

Beitrag zur Morphologie und Enzymhistochemie experimenteller Tumoren des Zentralnervensystem der Ratte

Zusammenfassung Bei zwei Gruppen von je 80 adulten Sprague-Dawley-Ratten beiderlei Geschlechts wurden wöchentlich 50 mg/kg KG Phenyl-dimethyl-triazen s.c. (Gruppe A) und zweimal wöchentlich 6 mg/kg KG N-Methyl-N-nitroso-harnstoff p.o. (Gruppe B) appliziert. Nach einer durchschnittlichen Induktionszeit von 185 bzw. 430 Tagen entwickelten die Tiere 116 ZNS-Tumoren, die mit Ausnahme von fünf vorläufig unklassifizierten Tumoren als primär isomorphe Gliome (29), primär heteromorphe Gliome (Mischgliome) (48), polymorphe Gliome (27) und Ependymome (7) klassifiziert werden konnten. Das morphologische bzw. biologische Verhalten dieser Tumoren wird erörtert und die Frage des Verhaltens des subependymären Glialagers unter Einwirkung neurotroper Carcinogene diskutiert.

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Morphology and enzyme histochemistry of experimental brain tumors in ratsI. Morphological findings

Summary CNS-tumors were induced experimentally in two groups of adult Sprague-Dawley-rats, each consisting of 80 animals, by s. c. administration of 50 mg/kg/week phenyldimethyl-triacene (group A) and per os administration of 6 mg/kg twice weekly 1-methyl-1-nitrosourea (group B). The average induction period in group A was about 185 days, in group B, however, about 430 days. Based upon morphological and biological criteria the tumors were grouped into a) primary isomorphic gliomas (29), b) primary heteromorphic gliomas [mixed gliomas (48)], c) polymorphic gliomas (27) and d) ependymomas (7). The relationship between subependymal cell layers, carcinogenic influences, and blastomatisation was taken into special consideration.

     

Die Morphologie der unteren Speiseröhre nach endoskopischer Varicenverödung

Zusammenfassung Submucöse Injektion von 5%igem Phenolerdnußöl in die untere Speiseröhre kann ohne bedeutende Komplikationen eine Blutung aus Oesophagusvaricen stillen. Mikroskopische Untersuchungen an 14 menschlichen Oesophaguspräparaten zeigen, daß Phenol in Öl im Gegensatz zu anderen Verödungslösungen nur eine milde, blande verlaufende Entzündung im Gewebe auslöst. Tiefe Schleimhautulceration, Wandperforationen, phlegmonöse Entzündungen oder Mediastinitiden wurden nicht beobachtet. Dennoch entsteht unter der intakten Oesophagusschleimhaut eine ausreichende Bindegewebsvermehrung, die eine Verödung der Varicen bewirkt.

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Morphology of the lower esophagus after endoscopic varicosclerosation

Summary Submucous injection of 5 p.c. phenol in arachis oil in the lower esophagus can stop a bleeding from esophageal piles without considerable complications. Microscopical examinations on 14 human esophagal specimens demonstrate that phenol in oil as opposed to other sclerosing solutions produces only a mild, bland running inflammation in the tissue. Deep mucosal ulcerations, perforations of the wall, phlegmonous inflammations or mediastinitis could not be observed. Nevertheless, under the intact esophageal mucosa a sufficient production of collagen fibres develops, which is effecting a varicosclerosation.

Herrn Prof. Dr. F. Stelzner zum 60. Geburtstag gewidmet     

Arterioläre Hyalinose in Hodenbiopsien

Zusammenfassung Das häufige Vorkommen arteriolärer Hyalinosen in Hoden verstorbener Patienten ist bekannt. Gleiche Gefäßveränderungen können auch in Hodenbiopsien und operativ entfernten Hoden gefunden werden. Um uns ein Bild über die Häufigkeit machen zu können, untersuchten wir eine Serie von 2400 Hodenbiopsien und einzelnen operativ entfernten Hoden systematisch lichtmikroskopisch, teils auch histochemisch und elektronenoptisch im Hinblick auf arterioläre Hyalinosen. Dabei konnten in 3,75% der Patienten typische Herde nachgewiesen werden (Durchschnittsalter 34 Jahre). An Hodengrundkrankheiten findet man vor allem tubuläre Atrophien (58%) oder Kryptorchismus (22% der Fälle mit Gefäß Veränderungen). Die histochemischen Reaktionen lassen vermuten, daß der Hauptteil der eingelagerten Substanz aus Lipoiden, besonders Lecithinen besteht. Daneben sind auch Mukopolysaccharide abgelagert. Elektronenoptisch handelt es sich vorwiegend um fein granuläre Depots mit Vakuolen und seltenen Myelinfiguren. In späteren Stadien ist subendothelial ferner elastinartiges Material zu sehen, an der Peripherie der Herde sind Kollagenfasern nachweisbar. Die pathogenetische Bedeutung dieser arteriolären Hyalinoseherde und ihre Ursache sind unklar.

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Arteriolar hyalinosis in testicular biopsies

Summary Arteriolar hyalinosis is a common post mortem finding in the testes of even young men. Identical arteriolar hyalinoses can be demonstrated in testicular biopsies of patients with infertility or in patients operated on for cryptorchidism. In a series of such biopsies from 2400 patients, the frequency of arteriolar hyalinosis was examined. In 7 cases with positive findings, histochemical studies were carried out and in an additional 14 biopsies electron microscopy was performed. Arteriolar hyalinosis was found in 3.75% of the 2,400 patients with disturbances of fertility or cryptorchidism. The mean age of these patients was 34 years. In 58% of the cases with arteriolar hyalinosis the basic testicular lesion was tubular atrophy, in 22% cryptorchidism. The arteriolar lesions were due to deposits of lipoids and mucopolysaccharides. Electron microscopy revealed a granular material with vacuoles and rarely myelin bodies below the endothelial layer and between myocytes and fibrocytes of the arteriolar wall. In later stages elastin-like material could be demonstrated in the vicinity of the endothelial cells and collagen fibers at the periphery of these deposits. The etiology of testicular arteriolar hyalinosis and its pathogenetic significance are not yet clear.

     

Noradrenaline-refractoriness in cultured glioma cells

Summary Rat glioma cells in culture (subclone C6-SK71) respond to 0.1 mM noradrenaline by a 100 fold elevation of the intracellular cyclic AMP concentration, and by a subsequent change in morphology. The glioma cells extend multiple processes to resemble the morphology of normal astrocytes in brain tissue. Evidence is presented that the responses are mediated by way of a -adrenergic receptor. Both the biochemical and the morphological responses to noradrenaline are visible within minutes, but the cells revert to the untreated condition within 8 hours. Addition of fresh noradrenaline does not alter the sequence of events. A refractory period in which neither effect could be evoked by a subsequent exposure to noradrenaline was observed to last about 50 hours and was not correlated with a change in the rate of cell growth.     

Discharge patterns evoked by depolarizing current injection in basal optic nucleus neurons of the pigeon

The nucleus of the basal optic root of the accessory optic system in birds is involved in optokinetic nystagmus, which stabilizes images on the retina by compensatory movements of the eyes. The present paper studies the physiological and morphological properties of basal optic neurons in the pigeon by using a brain slice preparation and intracellular recordings. Sixty-one cells examined could be categorized into six types based on their firing patterns in response to depolarizing current injection. Type I cells (54%) fire spontaneously and more spikes as current intensity is increased. Type II cells (15%) discharge regular spikes with similar interspike intervals. Type III cells (5%) show an early burst followed by tonic firing. Type IV cells (5%) fire regular bursts with similar interburst intervals. Type V cells (16%) fire a few spikes in a cluster only at onset of current application. Type VI cells (5%) produce a hump-like depolarization or a single spike depending on current intensities. Seventeen cells stained with Lucifer yellow have multipolar or piriform perikarya (15-28 microm) with two to eight primary dendrites. In some cases, an axon is observed to originate from the cell body, traveling dorsolaterally or dorsally. The physiological significance of these findings is discussed.