丙泊酚和丙泊酚联合芬太尼在无痛人工流产术中的应用比较

[目的]比较丙泊酚和丙泊酚联合芬太尼在无痛人工流产术中的安全性及有效性.[方法]随机将行无痛人工流产术的60例患者分为丙泊酚麻醉组(A组)和丙泊酚+芬太尼麻醉组(B组).观察比较两组患者麻醉前后心率(HR)、平均动脉压(MAP)和血氧饱和度(SpO2)变化,麻醉效果及术后不良反应发生率.[结果]A组患者HR、MAP和SpO2变化程度高于B组,且两组比较差异具有显著性(P<0.05).A组药效初始发挥时间、药效作用时间均长于B组,且差异有显著性(P<0.05).A组患者总有效率为30%(9/30)低于B组83.33%(25/30)(P<0.05).A组嗜睡和恶心呕吐等不良反应发生率均高于B组,且差异有显著性(P<0.05).[结论]对于无痛人工流产术,芬太尼+丙泊酚麻醉的效果更为满意,值得临床推广.     

丁苯酞联合长春西汀治疗椎动脉优势型后循环缺血性眩晕的疗效及安全性分析

【目的】探讨丁苯酞联合长春西汀治疗椎动脉优势型后循环缺血性眩晕（PCIV）的有效性与安全性。【方法】将本院2014年1月至2015年10月收治的椎动脉优势型PCIV患者82例随机分为观察组及对照组两组,每组各41例。对照组应用篝春西汀治疗,观察组应用丁苯酞联合长春西汀治疗,对比两组的临床疗效与副作用。【结果】观察组治愈率及总有效率（48．78％、92．68％）显著高于对照组（29．27％、80．49％）;治疗后观察组的双侧椎动脉（LVA、RLA）、双侧大脑后动脉（LPCA、RPCA）及基底动脉（BA）的平均血流速度（Vm）显著高于对照组,而血液流变学指标（WBV、PV、PAI）显著低于对照组,差异均具有统计学意义（P〈0．05）。【结论】丁苯酞联合长春西汀治疗PCIV疗效确切且用药安全,能够有效改善患者的血液流变学以及后循环缺血症状。     

Local microwave hyperthermia (43° C) and stimulation of the macrophage and T-lymphocyte systems in treatment of Guerin epithelioma in rats

Summary Rats bearing Guerin epithelioma were exposed to 3 or 6 sessions of local microwave hyperthermia (LMwH) (2450 MHz, tumor temperature 43° C, time of exposition 45 min) on the 3rd or 5th week after implantation of tumor cells. In some of the animals LMwH was combined with the administration of immunopotentiating (IP) substances—purified Streptolysin S (SLS) (1 mg/kg b.w.) or Corynebacterium parvum (CP) (1 mg/kg b.w., intratumorally)-injected 3 times weekly on the 4th and 6th weeks after implantation of tumor cells. All the animals were immunized with bovine serum albumine (BSA) 2 and 3 weeks after tumor implantation. Size of tumors was measured each 4 days and the growth curves were analysed. Eight weeks after implantation all the animals were killed and the following tests were performed: weight of tumors, BSA antibodies titre (passive hemagglutination test using BSA-glutaraldehyde coupled sheep red blood cells), ³H-leucine and ³H-uridine incorporation to phytohemagglutinin (PHA)-stimulated spleen lymphocytes and to mixed tumor cell-lymphocyte cultures, cytotoxicity of isolated spleen lymphocytes and peritoneal macrophages to ⁵¹Cr-labeled primary cultures of Guerin tumor cells, lysozyme (muramidase) activity in blood serum.LMwH inhibited growth of Guerin tumors and the effect was enhanced by combined treatment with IP substances. Combined application of LMwH and CP resulted in complete disappearance of 9 of 12 tumors, while LMwH and IP applied separately led to eradication of 2–5 tumors of 12.LMwH stimulated reactivity of the T-lymphocyte and macrophage systems enhancing both non-specific (increased production of BSA antibodies, high reactivity of spleen lymphocytes to PHA, increased serum lysozyme levels) and specific (increased cytotoxicity of lymphocytes and macrophages to cultured tumor cells and higher reactivity of lymphocytes to mitomycin-inhibited tumor cells) immune responses.The role of immunostimulation by LMwH is stressed as an important factor in tumor-inhibiting effect of hyperthermia in addition to the well known selective heat killing of neoplastic cells.This work was supported by research grants 05-339-C from the US Public Health Service and PR-6-210-02 from the Polish Governmental Program     

替罗非斑治疗老年糖尿病足0级病变的临床效果观察

【目的】观察替罗非斑治疗老年糖尿病足0级病变的临床效果。【方法】将58例老年糖尿病足0级病变的患者随机分办试验组和对照组。对照组实施常规糖尿病治疗,活血化瘀治疗。试验组在常规治疗基础上给予替罗非斑静滴。观察治疗后临床症状、血液流变学以及血液动力学改善情况。【结果】与治疗前比较,试验组治疗后病人临床症状,血液流变学以及血流动力学改善明显（P〈0．05）;试验组改善亦优于对照组（P〈0．05）。【结论】替罗非斑对老年糖尿病足0级病变的疗效显著、安全。     

干扰素超声雾化法对呼吸道合胞病毒肺炎的疗效观察

我科于1988年冬春季节收治呼吸道合胞病毒肺炎患儿60例(均由病原学确诊),随机分为两组,均常规应用综合治疗,治疗组另加用干扰素雾化吸入。对比观察主要症状、体征和胸片。结果治疗组发热及其它症状改善时间均比对照组明显缩短(P<0.05、p<0.01).同时对干扰素的用法及用量进行了讨论。     

Inactivation of AH-130 ascites tumour cells by exposure to a haematoporphyrin derivative and microwaves

The cytotoxic effects of a haematoporphyrin derivative and microwave irradiation on AH-130 ascites tumour cells were examined. The tumour cells were incubated for 120 min in rat ascites fluid with 50 μg/ml of the haematoporphyrin derivative and then exposed to microwave irradiation at 2450 MHz at a power of 20 mW. Irradiation for 30 s with a 30-s pause was repeated 20 times. Treatment with the haematoporphyrin derivative and then microwaves resulted in a significant increase in the frequency of tumour cells showing degenerative changes and a significantly longer survival of rats bearing tumour cells. Phase-contrast and electron microscopic studies showed that the cytotoxicity was associated with mitochondrial damage, dilatation of the rough endoplasmic reticulum, and alteration of the nuclear membrane. The temperature did not rise above 39 °C during irradiation. Neither dye alone nor microwaves alone had any effect. Superoxide dismutase prevented the cytotoxic effects on tumour cells resulting from exposure to haematoporphyrin and microwave irradiation. Thus oxygen radicals may be related to the cytotoxicity of this system.     

Note on the oscillations of collapsible tubes

Evidence that the conditions downstream of an elastic constriction can strongly influence the frequency and existence of oscillations in collapsible tubes is presented. A lumped negative resistance model is used to describe oscillations in collapsible tubes. An extension of the existing theory is presented which takes into account the influence of distributed loads on the collapsible tube.     

192例剖宫产术前应用头孢噻肟钠预防术后感染的观察

对１９２例剖宫产病人在抗菌毒的选择及用药方法上进行前瞻性研究。将剖宫产病人随机分为两组，术前用头孢噻肟钠组４１例；术后传统联合用药组１５１例。通过对两组术后感染率的分析，术前用药组与常规术后用药组对术后感染的预防作用无显著差异，但术前用药系一次性用药，且副作用少、简便、不影响婴儿早吸吮，故值得推广。     

Antigen specific in vitro activity of lymphocyte subpopulations from Mantoux positive and negative subjects assessed by lymphocyte proliferation assay

A micromethod for the lymphocyte proliferative assay and multifactorial analysis of stimulation indices classified according to subjects, lymphocyte combinations and antigens was used to elucidate deficient Mantoux (Mx) reactions in BCG-vaccinated subjects. It was possible to group each of the factors so that interactions between the two latter factors were not present within but only between groups. Comparisons between the subject groups showed a clear association between results of this in vitro test with PPD antigen and the Mx test carried out with 1 TU. The in vitro test had the advantage of being more sensitive and of not introducing the immune reactions occasionally seen with the Mx test. Thymus-processed lymphocytes were the cells responsible with functions both as effector and regulator cells, B lymphocytes had only regulatory properties.     

维生素E对烧伤后心室肌受损之保护作用的观察

本实验对30％、Ⅲ°体表烧伤后24h的大鼠心室肌组织匀浆丙二醛含量与心室肌形态进行检测与观察,结果发现自由基是烧伤后心室肌受损的因素之一,伤前应用自由基清除剂(维生素E)对烧伤后心室肌有明显的保护作用。