银屑病治疗不当致汞中毒临床分析

目的了解银屑病治疗不当导致汞中毒的临床特点。方法分析总结北京朝阳医院14例因银屑病治疗不当导致汞中毒患者的临床特点,包括临床症状和体征、实验室检查指标以及治疗效果。结果 14例汞中毒患者均为使用中药偏方引起,其中熏蒸吸入者5例,口服者4例,外用者2例,口服联合外用者3例。汞中毒患者主要出现神经衰弱征候群、消化道症状、周围神经损害和肾脏损害。汞中毒的临床表现及化学检测结果均有其特异性。早期诊断和使用特效解毒剂治疗,多数患者能取得良好疗效。结论对银屑病进行规范治疗,避免治疗误区,对防止患者汞中毒的发生有重要意义。     

代谢组学实验技术在中医药科研中的应用

代谢组学是关于生物体代谢物质种类、数量及其变化规律的学科,它可以应用现代分析技术方法对某一生物、细胞在一特定生理时期内所有代谢产物进行定性和定量分析。随着代谢组学在医疗、卫生领域的广泛应用,中医药与代谢组学技术的有机结合成为必然,给中医药的发展研究提供了强有力的手段。运用代谢组学方法在阐明中医整体思维、辨证论治及中药的疗效、安全性等方面展示了优势地位,对于研究中药的整体调节作用,多成分、多靶点作用等有巨大的潜力。     

《中药鉴定学》“说课”实例与体会

经验"说课"是一种新兴的教研形式,它是指教师在特定的场合,在精心备课的基础上,面对评委、同行或教研人员系统地口头表述自己对某节课(或某单元)的教学设计及其理论依据,然后由听者评议,     

Nitrosamine Contamination in Pharmaceuticals: Threat,Impact, and Control

Nitrosamine-contaminated medicinal products have raised safety concerns towards the use of various drugs, not only valsartan and all tetrazole-containing angiotensin II receptor blockers, but also ranitidine, metformin, and other medicines, many of which have been recalled and prone to shortage. At any stages, from drug substance synthesis throughout each product's lifetime, these impurities may evolve if an amine reacts with a nitrosating agent coexisting under appropriate conditions. Consequently, drug regulatory authorities worldwide have established stringent guidelines on nitrosamine contamination for all drug products in the market. This review encompasses various critical elements contributing to successful control measures against current and upcoming nitrosamine issues, ranging from accumulated knowledge of their toxicity concerns and potential root causes, precise risk evaluation, as well as suitable analytical techniques with sufficient sensitivity for impurity determination. With all these tools equipped, the impact of nitrosamine contamination in pharmaceuticals should be mitigated. An evaluation aid to tackle challenges in risk identification, as well as suitable industry-friendly analytical techniques to determine nitrosamines and other mutagenic impurities, are among unmet needs that will significantly simplify the risk assessment process.     

建立香港中药不良反应监测系统,发挥中医药在药物滥用防治中的作用

药物滥用是造成药物不良反应的重要原因之一,我国将滥用麻醉药品等称为"吸毒",是形成药物依赖性的主要原因。药物依赖性包括生理依赖和     

稀土元素与人体健康

本文讨论了稀土元素的代谢、生物效应和医药保健作用，研究稀土元素对人体健康和生物医学等方面具有的重要意义。     

Hospital inpatient self-administration of medicine programmes: a critical literature review

Aim The Department of Health, pharmaceutical and nursing bodies have advocated the benefits of self- administration programmes (SAPs), but their implementation within UK hospitals has been limited. Perceived barriers are: anticipated increased workload, insufficient resources and patient safety concerns. This review aims to discover if benefits of SAPs are supported in the literature in relation to risk and resource implications.Method Electronic databases were searched up to March 2004. Published English language articles that described and evaluated implementation of an SAP were included. Outcomes reported were: compliance measures, errors, knowledge, patient satisfaction, and nursing and pharmacy time.Results Most of the 51 papers reviewed had methodological flaws. SAPs varied widely in content and structure. Twelve studies (10 controlled) measured compliance by tablet counts. Of 7 studies subjected to statistical analysis, four demonstrated a significant difference in compliance between SAP and controls. Eight studies (5 controlled) measured errors as an outcome. Of the two evaluated statistically, only one demonstrated significantly fewer medication errors in the SAP group than in controls. Seventeen papers (11 controlled) studied the effect of SAPs on patients’ medication knowledge. Ten of the 11 statistically analysed studies showed that SAP participants knew significantly more about some aspects of their medication than did controls. Seventeen studies (5 controlled), measured patient satisfaction. Two studies were statistically analysed and these studies suggested that patients were satisfied and preferred SAP. Seven papers studied pharmacy time, three studied nursing time but results were not compared to controls.Conclusions The paucity of well-designed studies, flawed methodology and inadequate reporting in many papers make conclusions hard to draw. Conclusive evidence that SAPs improve compliance was not provided. Although patients participating in SAPs make errors, small numbers of patients are often responsible for a large number of errors. Whilst most studies suggest that SAPs increase patient’s knowledge in part, it is difficult to separate out the effect of the educational component of many SAPs. Most patients who participated in SAPs were satisfied with their care and many would choose to take part in a SAP in the future. No studies measured the total resource requirement of implementing and maintaining a SAP.     

黔东南自治州侗药物种多样性研究

黔东南地区由于地理位置的独特性，保育着多种多样的药用物种。本文从该地区侗族药物物种成分、珍稀濒危药物、植被类型等方面分析阐述了黔东南地区侗族药物的多样性，并提出了保护黔东南地区侗族药物多样性的措施。     

中药防治动脉粥样硬化研究现状述评

简要评述中药防治动脉粥样硬化的研究现状，研究证实多种中药通过调节脂质代谢、保护血管内皮细胞、抑制脂质过氧化、抑制血管平滑肌增殖、调节增殖与凋亡之间的平衡、抗炎症反应等一系列途径和环节，干预和治疗由A軎病变所引起的心脑血管疾病。     

突发性耳聋的疗效探索

目的 探索突发性耳聋的有效治疗方案。方法 将我科近年来收治的394例突聋患者分为5组。第一组中西医结合治疗40例。在此基础上，第二组加体外反搏治疗44例，第三组加高压氧舱治疗46例，第四组加光量子血液疗法46例；第五组加声信息治疗52例。与之比较相应各组的中西医结合组分别为42例、44例、40例和40例。结果 第一组有效率70．0％，第二组有效率86．4％，第三组有效率89．1％，第四组有效率93．5％，第五组有效率88．5％。第一组与其余4组的疗效差异有显著性意义（P＜0．05）。结论 药物治疗的同时加用各种特殊治疗，均将取得更好的疗效。