氯丙嗪剂量、给药方式与副反应的关系研究

调查1997年4月至1997年9月出院病例服用氯丙嗪的精神病患者389例,出现药物副反应的为200例(51.4％),其中心电图改变者131例(65.5％),锥体外系副反应57例(28.6％),SGPT升高52例(26.0％),脑电图改变26例(13.0％),皮疹22例(11.0％),胃肠道副反应16例(8.0％),造血系统副反应12例(6.0％),体位性低血压9例(4.5％),内分泌系统副反应4例(2.0％),其他12例(6.0％)。对上述副反应发生的原因和处理作了分析。     

消炎痛灌肠降温疗效观察

对体温在３８．５℃以上的患儿进行了消炎痛灌肠与安痛定肌注降温疗效观察。结果表明：消炎痛灌肠组的显效率为７８％，安痛定肌注组的显效率为３４％。     

50例肺癌患者中西医结合治疗后舌脉象参数的变化

目的:观察肺癌患者中西医结合治疗后其舌脉象参数变化情况,探讨舌脉象参数变化在肺癌患者中西医结合治疗过程中的临床意义。方法:于2015年1月至2016年4月,选取该阶段内我院采取中西医结合疗法治疗的50例肺癌患者作为此次研究的对象,分别于治疗前、治疗后1个月、治疗后2个月,采用舌脉象数字化分析仪对肺癌患者的舌象图片和关部脉图进行检测,比较治疗前、治疗后1个月、治疗后2个月患者的舌象参数、脉象参数。结果:与治疗前相比,治疗后1个月、治疗后2个月肺癌患者脉象参数中的PSR1明显增高(P0.05),PSR2明显降低(P0.05);与治疗后1个月相比,治疗后2个月肺癌患者脉象参数中的PSR1明显降低(P0.05),PSR2、PSR3均明显增高(P0.05);治疗前与治疗后相比,肺癌患者的脉象参数CSR1、CSR2、CSR3均未出现明显改变(P0.05)。与治疗前相比,治疗后1个月肺癌患者的舌象润燥指数、腐腻指数、裂纹指数均明显增高(P0.05),厚薄指数明显降低(P0.05);与治疗后1个月相比,治疗后2个月肺癌患者的裂纹指数明显降低(P0.05),厚薄指数明显增高(P0.05),润燥指数和腐腻指数未发生明显改变(P0.05)。结论:在肺癌患者采用中西医结合疗法治疗的过程中,舌脉象参数的变化可有效反映肺癌患者的中西医结合治疗效果,可作为中西医结合治疗肺癌的疗效评估指标。     

搜风通络汤治疗PEID术后20例神经根症状临床研究

目的:通过临床对比研究,分析搜风通络汤对腰椎间盘突出症经皮椎间孔镜技术(PEID)术后神经根症状恢复情况的影响,并与肌松药盐酸乙哌立松功效作比较。方法:选择腰椎间盘突出症PEID术后患者60例,随机分成基础组、治疗组、对照组各20例,基础组予地塞米松抗炎止痛联合甘露醇脱水治疗,治疗组加服搜风通络汤,对照组加用盐酸乙哌立松,分别在术后3 d、术后1周、术后4周三个时间点用JOA评分和VAS评分评价三组治疗效果。结果:术后3 d,三组之间JOA及VAS评分差异无统计学意义(P0.05);术后1周、术后4周,三组之间JOA及VAS评分差异有统计学意义(P0.05),治疗组与对照组疗效优于基础组,且治疗组疗效优于对照组;结论:搜风通络汤对腰椎间盘突出症PEID术后遗留神经根症状有持续改善效果,并且临床疗效优于盐酸乙哌立松。     

重楼替代药材丫蕊花研究进展

百合科(Liliaceae)丫蕊花属植物具有和重楼属十分相似的化学成分及药理活性。丫蕊花和重楼活性成分主要为甾体皂苷,具有抗菌、止血、抗肿瘤等药理作用,因此丫蕊花具有替代重楼的药效物质基础,可在一定程度上缓解重楼资源危机。综述丫蕊花的研究进展,以期为加快丫蕊花的研究开发和利用提供参考。     

Physiology of the normal heart

The mechanical events of the cardiac cycle provide the circulation with normal cardiac output and blood pressure. This requires an appropriate venous return, regulation of outflow resistance, a normal myocardial contractile state and heart rate control, together with an adequate supply of oxygenated blood via the coronary circulation. Other neural influences contribute to cardiac regulation, including natriuretic peptides and the renin–angiotensin system. The atria and ventricles are richly supplied with adrenergic nerves that may augment cardiac function, particularly with increased cardiac output during exercise. Inhibitory vagal fibres are largely confined to the sinus and atrioventricular nodes. Exercise causes increased sympathetic outflow, with a decrease in peripheral vascular resistance and increased cardiac output, heart rate, systolic blood pressure and venous return. Regular rhythmic exercise has a training effect, which enhances cardiac performance. This is important for the maintenance of many aspects of cardiovascular health.     

Role of dexamethasone in the long‐term functional maturation of MSC‐laden hyaluronic acid hydrogels for cartilage tissue engineering

The purpose of study was to investigate the maturation of mesenchymal stem cells (MSC) laden in HA constructs with various combinations of chemically defined medium (CM) components and determine the impact of dexamethasone and serum on construct properties. Constructs were cultured in CM with the addition or withdrawal of media components or were transferred to serum containing media that partially represents an in vivo‐like condition where pro‐inflammatory signals are present. Constructs cultured in CM+ (CM with TGF‐β3) and DEX? (CM+ without dexamethasone) conditions produced robust matrix, while those in ITS/BSA/LA? (CM+ without ITS/BSA/LA) and Serum+ (10% FBS with TGF‐β3) produced little matrix. While construct properties in DEX? were greater than those in CM+ at 4 weeks, properties in CM+ and DEX? reversed by 8 weeks. While construct properties in DEX? were greater than those in CM+ at 4 weeks, the continued absence or removal of dexamethasone resulted in marked GAG loss by 8 weeks. Conversely, the continued presence or new addition of dexamethasone at 4 weeks further improved or maintained construct properties through 8 weeks. Finally, when constructs were converted to Serum (in the continued presence of TGF‐β3 with or without dexamethasone) after pre‐culture in CM+ for 4 weeks, GAG loss was attenuated with addition of dexamethasone. Interestingly, however, collagen content and type was not impacted. In conclusion, dexamethasone influences the functional maturation of MSC‐laden HA constructs, and may help to maintain properties during long‐term culture or with in vivo translation by repressing pro‐inflammatory signals. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1717–1727, 2018.