全文获取类型
收费全文 | 42939篇 |
免费 | 3464篇 |
国内免费 | 1318篇 |
专业分类
耳鼻咽喉 | 307篇 |
儿科学 | 252篇 |
妇产科学 | 209篇 |
基础医学 | 2502篇 |
口腔科学 | 558篇 |
临床医学 | 3996篇 |
内科学 | 2839篇 |
皮肤病学 | 451篇 |
神经病学 | 1739篇 |
特种医学 | 1323篇 |
外国民族医学 | 7篇 |
外科学 | 1803篇 |
综合类 | 9744篇 |
现状与发展 | 5篇 |
预防医学 | 5426篇 |
眼科学 | 661篇 |
药学 | 8564篇 |
507篇 | |
中国医学 | 4883篇 |
肿瘤学 | 1945篇 |
出版年
2024年 | 158篇 |
2023年 | 603篇 |
2022年 | 1394篇 |
2021年 | 1921篇 |
2020年 | 2043篇 |
2019年 | 1092篇 |
2018年 | 1111篇 |
2017年 | 1600篇 |
2016年 | 2190篇 |
2015年 | 1951篇 |
2014年 | 4067篇 |
2013年 | 3691篇 |
2012年 | 3192篇 |
2011年 | 2936篇 |
2010年 | 2262篇 |
2009年 | 1915篇 |
2008年 | 1782篇 |
2007年 | 1878篇 |
2006年 | 1622篇 |
2005年 | 1372篇 |
2004年 | 1040篇 |
2003年 | 966篇 |
2002年 | 821篇 |
2001年 | 724篇 |
2000年 | 567篇 |
1999年 | 535篇 |
1998年 | 437篇 |
1997年 | 365篇 |
1996年 | 343篇 |
1995年 | 329篇 |
1994年 | 295篇 |
1993年 | 235篇 |
1992年 | 247篇 |
1991年 | 219篇 |
1990年 | 197篇 |
1989年 | 200篇 |
1988年 | 191篇 |
1987年 | 143篇 |
1986年 | 143篇 |
1985年 | 173篇 |
1984年 | 135篇 |
1983年 | 90篇 |
1982年 | 103篇 |
1981年 | 74篇 |
1980年 | 59篇 |
1979年 | 70篇 |
1978年 | 52篇 |
1977年 | 59篇 |
1976年 | 41篇 |
1975年 | 36篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
31.
前列腺癌去雄激素治疗不良反应的预防和处理 总被引:1,自引:0,他引:1
目的观察去雄激素治疗前列腺癌的不良反应,并探讨其预防和治疗。方法回顾性分析1998年7月-2006年1月112例去雄激素治疗晚期前列腺癌的临床资料。结果112例患者中,97例完成了不良反应的调查。随访3-36月,去雄激素治疗后潮热、性功能障碍、病理性骨折发生率分别为46%、75%、4%;患者潮热、精神疲乏、四肢乏力、纳差症状明显加重(P<0.05);性功能明显减退(P<0.05)。12例潮热症状严重者使用抗抑郁药博乐欣(25mg,tid)1-2周症状减轻。7例有骨转移性疼痛或严重骨质疏松患者,应用唑来膦酸4mg静脉滴注,每45d一次,骨痛症状缓解。结论去雄激素对前列腺癌患者生活质量有一定影响。博乐欣可减轻患者潮热症状,唑来膦酸可预防和治疗去雄激素相关的骨质疏松并发症。 相似文献
32.
目的 研究羊柄菜多糖复方制剂对γ射线照射小鼠的抗辐射作用.方法 将小鼠分为空白对照组、模型对照组及羊栖菜多糖复方制剂低[0.692g/(kg·d)]、中[2.075g/(kg·d)]、高[4.150g/(kg·d)]3个剂量组,以方格星虫提取物为阳性对照组,每天灌胃给药1次,灌胃2周后用60Co γ射线进行1次全身照射.测定小鼠外周血白细胞(WBC)、血小板和血细胞计数,以及脾指数(TI)、胸腺指数(SI)、骨髓有核细胞计数(BMWC)、血清超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量等指标.结果 3个剂量组小鼠与模型组比较,WBC均有上升趋势,但仅中剂量组在照后第14天与模型组差异有统计学意义(P<0.05).3个剂量组TI均明显高于模型组(P<0.05),SI和BMNC仅中、高剂量组明显高于模型组(P<0.05),SOD低、中剂量组明显高于模型组(P<0.05),MDA中、高剂量组低于模型组(P<0.05或P<0.01).结论 羊栖菜多糖复方制剂能有效提高小鼠的抗辐射能力. 相似文献
33.
34.
Plasma concentrations and bioavailability of propranolol by oral, rectal, and intravenous administration in man 总被引:2,自引:0,他引:2
E Cid F Mella L Lucchini M Cárcamo J Monasterio 《Biopharmaceutics & drug disposition》1986,7(6):559-566
Eight normal male volunteers received 80 mg doses of propranolol by the oral and rectal routes and 2.2 mg by intravenous administration in a crossover fashion. Plasma concentrations of propranolol were measured by a gas chromatographic method using an electron capture detector. Individual subject concentration-time data were analysed and results indicated that the data fit a two compartment model with first order absorption. An approximately two-fold higher plasma propranolol concentration was observed after rectal administration as compared with oral dosing. Statistical analysis of the difference in the total AUCs indicates a significantly higher bioavailability of propranolol administered by the rectal route. The reduced bioavailability after oral administration indicates a substantial first pass effect but that it is possible to bypass the liver, at least partially, by giving the drug rectally to man. 相似文献
35.
Thomas Abel William C. Cockerham Guenther Lueschen Gerhard Kunz 《Social science & medicine (1982)》1989,28(12):1269-1274
This paper examines whether American males with a high degree of control over their work situation pursue healthy lifestyles and rate their physical health more positively than those who score low on occupational self-direction. That is, are persons who control their work more likely to also try to control their health through living in a particularly healthy manner? We found that there was no support for a spillover effect from high occupational self-direction to enhanced participation in health lifestyles or more positive self-rated health. The findings suggest health lifestyles have spread throughout occupational work groups in the U.S. and support research that maintains such lifestyles have spread across social strata in America. 相似文献
36.
目的:观察高压氧结合针灸治疗脑外伤患者的疗效。方法:对96例脑外伤患者采用高压氧、针灸配合药物进行综合治疗。同时,对83例对照组患者根据病情给予降颅压、抗感染、改善脑供血、保护脑细胞等治疗,有手术指征者行清除血肿、减压和清创术。结果:出院时两组患者功能比较,治疗组明显优于对照组,有显著性差异(P<0.O1),疗效治疗组也明显好于对照组。结论:高压氧结合针灸治疗能够明显提高脑损伤患者疗效,对肢体功能有明显提高。 相似文献
37.
38.
目的 评价善宁对顽固性大咯血的疗效。方法 将55例传统药物抢救无效或有禁忌的大咯血分为治疗组(善宁)与对照组(立止血组),观察24—72h的止血效果。结果 治疗组总有效率为92%,对照组为70%,两组比较有显著差异p〈0.05(x^2=4.125)。结论 善宁治疗大咯血疗效显著,使用安全,不良反应少,值得临床推广应用。 相似文献
39.
Two experiments investigated the effects of haloperidol (0.1 mg/kg) on the partial reinforcement extinction effect (PREE). In experiment 1 two groups of rats were trained to run in a straight alley using six trials/day with an intertrial interval (ITI) of 5–8 min. The continuously reinforced (CRF) group received food reward on every trial. The partially reinforced (PRF) group was rewarded on a quasi-random 50% schedule. All animals were then tested in extinction. Haloperidol was administered in a 2 × 2 design, i.e., drug-no drug in acquisition and drug-no drug in extinction. In experiment 2 two groups of rats were trained to press a lever in an operant chamber using a discrete trial procedure of ten trials/day with an ITI of 60 s. The CRF group was rewarded on each trial and the PRF group was rewarded on a quasi-random 50% schedule. Haloperidol was administered for 22 days prior to the start of the PREE procedure as well as throughout acquisition and extinction. The PREE, i.e., increased resistance to extinction of PRF as compared to CRF animals, was obtained in both experiments in all drug conditions. In both experiments haloperidol increased the rate of extinction. Experiment 1 revealed that this effect was entirely dur to the administration of the drug in extinction, independently of the drug condition in acquisition. In contrast to previous results in a one trial/day procedure, the administration of haloperidol to CRF animals did not increase resistance to extinction, failing to support the notion that neuroleptics attenuate the rewarding properties of reinforcement. 相似文献
40.
C. H. van der Meyden J. F. K. de Villiers B. D. Middlecote J. Terblanchè 《Neuroradiology》1994,36(3):221-223
A 9-year-old boy presented with a subacute history of optic neuritis followed by brainstem involvement, with fever and a lymphocytic pleocytosis in the cerebrospinal fluid. Gadolinium-enhancing ring lesions were demonstrate in the white matter of the cerebrum, brainstem and cerebellum on day 17 of the illness, all appearing simultaneously as part of a monophasic illness. A parietal lesion exerted mass effect. Needling and biopsy yielded no evidence of a pyogenic lesion, tumour or tuberculosis and showed vasculitis. There was insufficient material for myelin staining. Dexamethasone therapy lead to rapid improvement of the radiological lesions: MRI and CT on day 34 of the illness showed complete clearing of the lesions except for residual abnormality at the biopsy site. 相似文献