多探针多模态PET/MR成像在高学历早发型阿尔兹海默病患者中应用价值

目的 探讨多探针多模态PET/MR成像在高学历早发型阿尔兹海默病(EOAD)患者中的应用价值.方法 选取华中科技大学同济医学院附属协和医院2021年收治的1例高学历EOAD患者为研究对象,将其分别与不同年龄、教育程度、简易精神状态量表(MMSE)评分的AD患者进行比较.所有患者均完成18 F-FDG、11 C-PIB、18 F-APN-1607 PET/MR.应用SPM12和MATLAB 2020b在标准空间中定义感兴趣区,提取各脑区的标准摄取值并计算标准摄取值比值(SUVR),比较各患者的PET/MR结果 .结果 高学历EOAD患者18 F-FDG PET成像显示后顶叶、后扣带回、顶颞叶交界区葡萄糖代谢减低,11 C-PIB PET和18 F-APN-1607 PET显示大脑皮层中广泛β-淀粉样蛋白(Aβ)和tau蛋白沉积.与教育程度和MMSE评分相似的迟发型阿尔茨海默病(LOAD)患者比较,EOAD患者在关键脑区的FDG摄取更低,tau蛋白沉积更明显,Aβ结果 存在不一致;与发病年龄和MMSE评分相似的、教育程度较低的EOAD患者比较,教育程度较高的EOAD患者的FDG摄取更低,Aβ和tau蛋白沉积更明显.结论 多探针多模态PET/MR成像可用于EOAD的诊断,还能够用于临床特征与影像学特征关系可能性的探索.     

MR diffusion-weighed imaging of rabbit liver

AIM: To study the techniques of MR diffusion-weighed imaging (DWI) for normal rabbit liver. METHODS: After 15 normal New Zealand white rabbits and one New Zealand white rabbit implanted with VX-2 tumor were anesthetized with 3% soluble pentobarbitone, DWI was performed respectively for different b values, repetition times (TR) or thicknesses, when other parameters were the same and magnetic resonance imaging (MRI) was performed respectively, or with different field of views (FOV) or coil when other parameters were the same. The distinction between groups was analyzed by SPSS10.0 with apparent diffusion coefficient (ADC), quality index (QI) or signal-noise ratio (SNR). RESULTS: As b value increased, liver ADC, QI and SNR of DWI became smaller and simultaneously (F=292.87, 156.1, 88.23, P<0.01). QI of DWI was high, when b value was 10, 50 or 100 respectively, but the distinction between them was insignificant; when b value was 800, QI and SNR of DWI were low. QI and SNR of DWI had no significant difference between TR=4000, 6000 and 8000. QI of DWI with 2 mm thickness was bigger than that with 5 mm thickness (t=3.04, P<0.01), but SNR of DWI with 2 mm thickness was significantly smaller (t=-17.86, P<0.01). SNR of MRI with knee joint coil was obviously bigger than that with cranium coil [t=-5.77 (T1WI) or -4.02 (T2WI), P<0.01], but QI of MRI was smaller on the contrary [t=7.10 (T1WI) or 3.97 (T2WI), P<0.01]. When FOV was enlarged gradually, SNR of MRI increased [F=85.81 (T1WI) or 221.96 (T2WI), P<0.01], but QI firstly increased, then decreased [F=68.67 (T1WI) or 69.46 (T2WI), P<0.01] and QI of MRI was the biggest when FOV was 20 cm脳15 cm. CONCLUSION: The scanning technique is very important in DWI of rabbit iiver and the overall quality of DWI with b (100 s/mm~2), thickness (2 mm), cranium coils and FOV (20 cm×15 cm) was best in our study, when other parameters were the same.     

颈动脉斑块MR高分辨成像在脑卒中高危人群筛选中的应用价值研究

目的:探究颈动脉斑块MR高分辨成像在脑卒中高危人群筛选中的应用价值。方法:选取2019年2—12月在我院接受颈动脉斑块M R高分辨成像检查的脑卒中高危人群84例,所有高危人群均接受M R高分辨成像及DSA造影检查,以DSA造影检查为金标准,对比MR高分辨成像与DSA造影的诊断结果,分析MR高分辨成像检测技术的诊断价值。结果:DSA造影检查84例;以病DSA造影检查诊断结果为“金标准”,MR高分辨成像诊断颈动脉斑块的灵敏度为91.94%,特异度为22.73%,准确度为88.10%,阳性预测值为91.84%,阴性预测值为77.27%;MR高分辨成像诊断颈动脉斑块与DSA造影具有极好一致性(Kappa=0.772);高危患者共发现斑块62处MR高分辨成像检出率(48.81%)与D S A造影检出率(52.38%)相比,差异无统计学意义(P>0.05)。结论:颈动脉斑块M R高分辨成像在脑卒中高危人群筛选中效果较好,血管狭窄检出率与准确率均较高,可以作为临床脑卒中高危人群筛选的诊断依据。     

CT及MR诊断腰椎间盘突出的效果观察及检出率分析

目的:观察腰椎间盘突出诊断中C T及M R的诊断效果,对腰椎间盘突出征象检出率进行比较分析。方法:从2019年11月—2020年11月在我院接受腰椎间盘突出诊疗的患者中选取100例进行研究。所有患者均接受CT诊断、MR诊断,以手术病理诊断结果为标准,分析CT诊断、MR诊断效果。结果:MR诊断灵敏度95.92%,特异度100.00%,阳性预测值100.00%,阴性预测值33.33%,误诊率0.00%,漏诊率4.08%,诊断符合率96.00%;C T诊断的灵敏度、特异度、阳性预测值、阴性预测值、误诊率、漏诊率、诊断符合率分别为86.73%、50.00%、98.84%、71.43%、50.00%、13.27%、85.00%;M R诊断的征象检出率高于C T诊断,且除神经根压迫检出率差异无统计学意义(P>0.05),其他征象检出率差异均有统计学意义(P<0.05)。结论:在腰椎间盘突出诊断中,CT及MR诊断均具有较高灵敏度、符合率,但相对而言MR诊断效果更好,可更好检出腰椎间盘突出征象,为临床诊疗提供可靠依据,值得推广使用。     

胰腺体尾部来源的黏液性囊性肿瘤及浆液性囊腺瘤:MR成像特点

<正>目的评估有助于鉴别胰腺体尾部来源黏液性囊性肿瘤(MCN)与浆液性囊腺瘤(SCA)的MRI及MRCP的影像征象。材料与方法该回顾性研究获得了机构伦理委员会     

多参数MR成像评估前列腺癌体积到底有多精确?

<正>目的评估影响多参数MR成像估算前列腺癌组织学体积(Vh)精确性的因素。方法对202例病人组成的前瞻性数据库进行回顾性研究,这些病人在行根治性前列腺切     

MR成像评估质子密度脂肪比例对非酒精性脂肪肝进行组织硬化分级

摘要目的评估之前提出的高特异性MR成像评估质子密度脂肪比(PDFF)临界值对肝硬化分级的诊断能力。用组织学征象作为参考标准,硬化≥1级(6.4%的PDFF临界     

新OPTN/UNOS分级系统用于MR检出的肝硬化结节:对肝细胞肝癌的检出和肝移植分配的影响

摘要目的在肝硬化并行肝动态对比增强MR成像的病人中,评估新的器官获取和移植网络(OPTN)/联合器官分配网络(UNOS)的政策对肝细胞肝癌(HCC)检出和肝移植分     

糖尿病足的非增强MR成像血管灌注区域

摘要目的本研究的摘要目的是开发一种非对比MRI方法来评估以足部的血管灌注区域为基础的糖尿病足的骨骼肌肉灌注情况。方法对5例健康志愿者和5例无外周动脉疾