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131.
M. Flesch A. Sachinidis Y. D. Ko K. Kraft H. Vetter 《Journal of molecular medicine (Berlin, Germany)》1994,72(12):944-950
In recent years there have been many studies demonstrating a correlation between increased arterial blood pressure and altered lipid profiles, and there has been an especially positive correlation between high cholesterol levels and blood pressure. There are differences between the various reports that are important. In our study the lipid distribution in 105 hypertensive patients with mild or moderate arterial hypertension according to WHO criteria without clinically or ultrasonographically apparent atherosclerosis was compared to the lipid distribution in 65 age-matched healthy persons. On the epidemiological level a significant, positive association was found between LDL serum levels (P 0.001), Apo B serum levels (P 0.001), serum triglyceride levels (P 0.05) and VLDL serum levels (P 0.01) and arterial hypertension. However, in contrast to recent reports, no significant difference was found between total serum cholesterol levels in normotensives and hypertensives, and there was no difference in HDL serum levels. No evidence could be found for a significant increase in lipoprotein (a) serum levels in hypertensives.Abbreviations LDL
low density lipoprotein
- VLDL
very low density lipoprotein
- HDL
high density lipoprotein
- Apo B 100
apolipoprotein B 100
- Apo A I
apolipoprotein A I
Correspondence to: H. Vetter 相似文献
132.
Larson IA Ordovas JM Sun Z Barnard Lohrmann J Feussner G Lamon-Fava S Schaefer EJ 《Clinical genetics》2002,61(6):430-436
The effects of apolipoprotein (apo) A-IV genotype on serum glucose, total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, triglyceride and glucose concentrations were ascertained in a population of 373 men and 361 women with a mean age of about 57 years. Subjects were evaluated at entry into a lifestyle intervention program. Apolipoprotein A-IV genotype variations at residues 347 and 360 were examined, as these mutations affect the sequence of apo A-IV, a major protein constituent of intestinal triglyceride-rich lipoprotein and HDL. With regard to the apo A-IV 360 mutation, 16.4% of the females and 13.4% of the males carried the apo A-IV 2-allele, almost entirely in the heterozygous state. No effect of the apo A-IV 1/2 genotype was observed in either men or women on total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, the total cholesterol (TC)/HDL ratio, or on A-I, A-IV and apo B levels. This was also the case for the apo A-IV 347 mutation. However, women with the apo A-IV 360 1/2 genotype had significantly (p < 0.005) higher glucose levels (105.5 mg/dl) compared with the 1/1 wild-type (94.0 mg/dl). All analyses were also adjusted for age, body mass index, medications, alcohol use and cigarette smoking. The prevalence of the 347 mutation was somewhat higher than the 360 mutation, with 29% of the females and 32.0% of the males being heterozygous for this mutation, and 3.9% of the females and 5.4% of the males being homozygous for this mutation. These data are consistent with the concept that the apo A-IV 360 and 347 genotypes have no significant effect on apo A-IV levels and other lipid parameters in either gender. However, apo A-IV 360 1/2 genotype did have a significant effect on serum glucose levels in women. 相似文献
133.
134.
目的 观察低密度脂蛋白(LDL)免疫吸附疗法对高脂血症的治疗效果.方法73例高脂血症患者接受LDL免疫吸附治疗.比较1次治疗前后各项血脂指标的变化.部分病例1个月后复查血脂各项指标.总结LDL免疫吸附疗法的安全性和副作用.结果①所有患者经1次LDL免疫吸附后血甘油三脂、胆固醇和低密度脂蛋白均有明显下降(p<0.01).高密度脂蛋白略有下降(p>0.05).患者临床症状改善.②治疗后1个月复查,血脂各项指标恢复到治疗前水平(p>0.05).③3例药物治疗不能控制的乳糜微粒血症患者经LDL免疫吸附治疗后血脂明显下降,但仍达不到正常范围.其中1例治疗后继续服用原降脂药物,药物疗效较前提高.④30例患者治疗过程出现低血压.结论LDL免疫吸附能有效降低血甘油三脂、胆圃醇和低密度脂蛋白水平,对高密度蛋白无明显影响.1次治疗所能维持血脂于低水平的时间短暂.部分患者临床症状改善.低血压是主要并发症. 相似文献
135.
Grimstone SK Hodges PW 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2003,151(2):218-224
This study evaluated the degree to which the disturbance to posture from respiration is compensated for in healthy normals
and whether this is different in people with recurrent low back pain (LBP), and to compare the changes when respiratory demand
is increased. Angular displacement of the lumbar spine and hips, and motion of the centre of pressure (COP), were recorded
with high resolution and respiratory phase was recorded from ribcage motion. With subjects standing in a relaxed posture,
recordings were made during quiet breathing, while breathing with increased dead-space to induce hypercapnoea, and while subjects
voluntarily increased their respiration to match ribcage expansion that was induced in the hypercapnoea condition. The relationship
between respiration and the movement parameters was measured from the coherence between breathing and COP and angular motion
at the frequency of respiration, and from averages triggered from the respiratory data. Small angular changes in the lumbopelvic
and hip angles were evident at the frequency of respiration in both groups. However, in quiet standing, the LBP subjects had
a greater displacement of their COP that was associated with respiration than the control subjects. The LBP group had a trend
for less hip motion. There were no changes in the movement parameters when respiratory demand increased involuntarily via
hypercapnoea, but when respiration increased voluntarily, the amplitude of motion and the displacement of the COP increased
in both groups. The present data suggest that the postural compensation to respiration counteracts at least part of the disturbance
to posture caused by respiration and that this compensation may be less effective in people with LBP. 相似文献
136.
137.
Apolipoprotein B gene DNA polymorphisms are associated with macro- and microangiopathy in non-insulin-dependent diabetes mellitus 总被引:2,自引:0,他引:2
Olavi Ukkola Markku J. Savolainen Pasi I. Salmela Kai von Dickhoff Y. Antero Kesäniemi 《Clinical genetics》1993,44(4):177-184
Ukkola O, Savolainen MJ, Salmela PI, von Dickhoff K, Kesäniemi YA. Apolipoprotein B gene DNA polymorphisms are associated with macro-and microangiopathy in non-insulin-dependent diabetes mellitus. Clin Genet 1993: 44: 177–184. © Munksgaard, 1993 The relationship between diabetic macroangiopathy or microangiopathy and apolipoprotein B (apoB) polymorphism was studied in 139 male and 129 female patients with non-insulin-dependent diabetes (NIDDM) mellitus, comprising consecutive patients with poor diabetic control (HBA1 13.2%\pm2.7 (SD)) referred to our hospital. Plasma cholesterol and triglyceride concentrations were higher in the patients who were homozygous for the X2 allele (presence of Xba I cleavage site). Patients with the X1 allele (absence of Xba I cleavage site) tended to have a higher frequency of macroangiopathy, although the differences were not statistically significant. There was no difference in the prevalence of microangiopathy between the groups. In subjects with only an R1 allele (= R +; homozygous for the presence of EcoR I cleavage site) the prevalence of coronary heart disease (CHD) was observed to be high (61.9%) as compared to the subjects possessing an R2 allele (= R —; homozygous or heterozygous for the absence of the EcoR I cleavage site) (46.7%; p<0.02). When the polymorphisms Xba I (subjects homozygous for the absence of the cutting site = X +; subjects homozygous or heterozygous for the presence of the cutting site = X —) and EcoR I were combined, the prevalence of macroangiopathy was observed to be high in X + R + (80.0%) as compared with X + R- (44.2%), X-R+ (56.8%) and X-R- (50.0%) (p<0.03). The prevalence of macroangiopathy tended to be particularly high in patients with the apoprotein E4 allele (phenotype E4\4 or E4/3), combined with either X+ or R +. Our findings suggest that variation at the apoB locus is one of the factors involved in predisposing diabetic patients to the development of arterial disease. As in previous studies the effect of the variation at the apoB gene on circulating lipid levels was observed. The data also support a role for the e4 allele of the apolipoprotein E gene as an important determinant of macroangiopathy in NIDDM. 相似文献
138.
The apolipoprotein (apo) B gene Xba I polymorphism is associated with alterations in serum lipids. Disturbances in serum lipids may be a risk factor for cholesterol gallstone disease. However, the relation between the Xba I polymorphism and cholesterol gallstones is unknown. This study was aimed at characterizing the polymorphism of the apo B gene Xba I in patients with gallbladder stones and the association of Xba I polymorphism with serum lipids. Xba I genotypes were measured by PCR-RFLP, and serum lipids assayed in 190 patients with gallbladder stones and 441 control subjects. The frequency of the X+/- genotype (20.63 vs. 7.94%) and X+ allele (10.79 vs. 3.97%) was significantly higher in the patient group than in the control group. Patients with the X+/- genotype had a significantly higher concentration of total cholesterol, low-density lipoprotein (LDL)-cholesterol, and apo B in serum than patients with the X-/- genotype. The X+ allele of the apo B gene is characterized by a higher cholesterol concentration and a higher LDL-cholesterol concentration in serum, and it may be a marker for increased risk of cholesterol gallstone disease. 相似文献
139.
Tessitore L Batetta B Vizio B Mulas MF Marengo B Dessi S 《International journal of experimental pathology》2000,81(4):241-248
Sexual dimorphism exists in the response of rats to lead nitrate, liver hyperplasia occuring earlier and being more pronounced in males. Excess dietary choline in females shifted the growth pattern towards that of males. To determine whether phosphatidylcholine-induced growth modulations could be related to a derangement of cholesterol metabolism, liver accumulation of cholesterol esters and plasma lipoprotein patterns were investigated. In males, lead-induced liver hyperplasia was associated with increased total cholesterol hepatic content, accumulated cholesterol esters and reduced concentration of plasma High Density Lipoprotein (HDL) cholesterol. Females were less responsive to the liver mitogenic signal of lead nitrate; there was no elevation of cholesterol content nor any marked accumulation of cholesterol esters. This is consistent with the lack of change in the plasma levels of HDL cholesterol. Continuous choline feeding displaced the liver cholesterol ester pattern and plasma HDL cholesterol levels in females, and in parallel that of DNA synthesis, towards those of males. Choline was not observed to have any effect in males. These results suggest that the derangement of phosphatidylcholine metabolism induces growth-related changes in cholesterol turnover; they are consistent with the proposal that the intracellular content of cholesterol esters may have a role in regulating liver growth rates. 相似文献
140.
Tarmi-Mattsson M Keskinen S Korhonen TT Lapinleimu H Tuominen J Niinikoski H Viikari J Ronnemaa T Välimäki I Simell O 《International journal of behavioral medicine》1997,4(4):310-322
Interventions aimed at decreased exposure of children to known atherosclerosis risk factors may have untoward behavioral side
effects. We examined how children’s behavior or parent’s perception of the behavior of the children at 3 years of age was
influenced by the intervention in a prospective randomized trial that began in infancy and effectively decreased scrum cholesterol
concentration. This Special Turku coronary Risk factor Intervention Project for babies (STRIP) began when the infant was 7
months old. Half of 1.062 children received individualized dietary counseling at 1-to 3-month intervals during the first 2
years of age and then half-yearly; the other half had an unrestricted diet. At 3 years of age a standardized questionnaire
of the child’s behavior was sent to 791 families (76% returned the questionnaire). At the onset of the trial the sociodemographic
data of the families and scrum lipid values of the intervention and control children were similar. Later, mean serum cholesterol
values of the intervention children remained constantly at a level 6% to 10% below the values of the control children. At
3 years of age the parental perceptions of the child’s behavior suggested minimal differences between the intervention and
control children. The intervention children were slightly less jealous and more active and creative, but showed slightly more
negative signs of behavior (bed-wetting, problems in falling asleep, fears) than the controls. We conclude that long-term,
individualized dietary and lifestyle intervention that begins in infancy slightly influences children’s behavior or parent’s
recognition of the behavior of the children at the age of 3 years.
This work was supported in part by grants from the Varsinais-Suomi Regional Fund of the Finnish Cultural Foundation, the Mannerheim
League for Child Welfare, the Academy of Finland, and the Alli Paasikivi Foundation. 相似文献