急性心肌梗死患者J波的临床研究

目的　研究心电图有 J波的急性心肌梗死 ( AMI)患者的临床情况。方法　选择住院的急性心肌梗死患者 10 2例 ,心电图有 J波者 5 0例为研究组 ,心电图无 J波者 5 2例为对照组 ,比较两组临床情况。结果　心电图有 J波组比心电图无 J波组发生胸闷 ( 3 0 /5 0∶ 2 0 /5 2 ,P<0 .0 5 )、前壁心肌梗死 ( 2 8/5 0∶ 18/5 2 ,P<0 .0 5 )、合并糖尿病 ( 14/5 0∶ 4/5 2 ,P<0 .0 5 )、超声心动图检查发生舒张功能减低 ( 2 4/5 0∶ 14/5 2 ,P<0 .0 5 )、心电图检查发现室性心动过速 ( 11/5 0∶ 1/5 1,P<0 .0 5 )者多。结论　心电图有 J波者比心电图无 J波者临床情况差 ,易于发生严重心律失常     

F wave studies after intrathecal methotrexate administration

Electrophysiological examinations were done on 20 patients aged 40–71 years with recently diagnosed high grade non-Hodgkin's lymphomas. General chemotherapy and intrathecal chemotherapy in order to prevent central nervous system (CNS) involvement were begun. On the first day of chemotherapeutic cycle patients received intrathecally methotrexate (ITMTX) and prednisolone. Electrophysiological study was carried out twice in each subject: before ITMTX injection and a day after injection. The study procedure included: a conventional nerve conduction examination (peripheral conduction velocity and compound muscle action potential amplitude), the F wave latency and amplitude measurement and F ratio (F-M-1/2M) calculation for peroneal and tibial nerve bilaterally. Results of the first and the second examinations were statistically compared by t-Student's test. No significant differences between values of estimated parameters were found. The study revealed no recent alterations in proximal, paraspinal motor conduction and motor neuron excitability due to antidromical activation after single ITMTX administration.     

超声显像诊断下肢深静脉血栓的临床应用

目的：探讨超声诊断下肢深静脉血栓的临床价值。方法：应用ＨＰ８５００多功能彩超仪，７．５ＭＨｚ线阵探头，外周血管软件检查临床疑下肢深静脉血栓３２例，另取１２例正常人２４条下肢深静脉作对照。２ＤＵＳ显示形态学改变，ＣＶＩ及ＰＷ模式观察血流状态。结果：超声检出下肢深静脉血栓形成２５例，除外血栓形成７例。２ＤＵＳ显示血栓形成部位血管内径明显增大，与患者健侧同水平深静脉内径进行配对ｔ检验，ｔ＝１３．８２，Ｐ     

Validity of Electrode Placement at Fpz to Detect Alpha Wave

Abstract: The possibility on placing electrodes at Fpz-A₂ instead of C₃-A₂ was investigated to obtain a more stable configuration avoiding obstruction by the hair. Our original system of alpha wave detection by a microcomputer was used, and a total of 22 all-night hypnograms of five healthy young students waa recorded. Pearson's moment correlation coefficients of alpha wave % between the two positions were 0.780–0.948. Except for one subject, alpha wave % taken at Fpz-A₂ tended to be 3–5% lower than that at C₃-A₂. The above analysis indicates that using EEG electrode position of Fpz-A₂ is valid and useful as a stable electrode configuration for a long-time monitoring.     

血流频谱分析在乳腺肿块鉴别诊断中的价值

目的：检验血流频谱分析在鉴别乳腺原发性肿块良恶性方面的价值并确立最佳的数值标准。方法：使用彩色多普勒血流显像和能量多普勒显像分别引导脉冲多普勒频谱分析，检查了１０４例乳腺原发性包块（良性５５例６３个病灶，恶性４９例６４个病灶），测量指标包括肿块周边与内部血流收缩期峰速、搏动指数及阻力指数，并分别绘制受试者工作曲线确定各自的最佳阈值。结果，以ＣＤＦＩ状态取频谱，乳癌病灶周边及内部血流的平均ＰＳＶ，Ｐ     

Estimation of instantaneous flow from the indicator-dilution curve after bolus injection of indicator

The indicator-dilution technique is commonly used to determine mean flow estimates. The estimation of instantaneous flow from the shape of an indicator-dilution curve is the objective of this study. Based on a mixing chamber approach to the flow system, a mathematical relationship is derived to reconstruct momentary flow from an indicator-dilution curve. This relationship is verified in a model setup both with only constant flow and with a sinusoidal flow variation superimposed. This method proved to give good flow estimates for limited values of flow parameters. Also, some preliminary experiments were performed in a pulsating flow system simulating heart action. The results were promising although the method proved to be very sensitive to baseline offset.     

The differential effect of optic nerve disease on pattern and focal electroretinograms

We studied nine cases of retrobulbar neuritis with confirmed multiple sclerosis and six cases of optic atrophy from other causes. Pattern and focal electroretinograms (macular ERGs) were recorded with high (400 cd/m²) and low (40 cd/m²) intensity stimuli. Contrast sensitivity was also measured with a simple printed test.Luminance was not markedly important. High spatial frequency contrast sensitivity was significantly correlated with pattern ERG amplitude. Pattern and focal ERG amplitude ratio was usually reduced, but the effect was not correlated with contrast sensitivity or large enough to be useful clinically.In optic atrophy the pattern ERG (PERG) was clearly more severely reduced than the focal ERG (FERG). In retrobulbar neuritis both ERGs were equally and more severely reduced even though the visual losses were less. In unilateral cases the PERG increased then decreased after the initial attack, as previously described (Arden et al., 1982). The results suggest that retinal layers beyond the ganglion cells may be affected in retrobulbar neuritis, but proximally generated, pattern-specific ERG components are selectively lost in optic atrophy.     

In vitro evaluation of ablation parameters of normal and fibrous aorta using smooth excimer laser coronary angioplasty

A modified exeimer laser energy delivery system was used to irradiate 100 segments of normal and fibrous aorta in vitro. The laser beam was scanned into 8 fiber bundles consisting of 50 fibers each resulting in a reduction of the applied pulse energy. The total repetition rate was increased to 150 Hz in order to keep the repetition rate per fiber bundle close to 20 Hz and to minimize thermal injury. The results demonstrate that effective ablation (etch rate per 8 pulses > 2.0 μm) occurred at an energy fluency of 50 mJ/mm² in both normal and fibrous aorta. Tissue damage (carbonization, tissue separation, fissures, cracks, and vacuolization) was in a range of 100 ± 28 to 152 ± 30 μm for normal aorta and in a range of 57 ± 35 to 110 ± 39 μm for fibrous aorta. We conclude that effective ablation of normal and fibrous human aorta can be achieved by the application of smooth excimer laser coronary angioplasty. This improvement of excimer laser technology may result in a reduction of shock wave- and cavitation-induced damage leading to a reduction of tissue injury. However, this awaits further in vitro and in vivo confirmation. © 1993 Wiley-Liss, Inc.     

42.3GHz毫米波电场治疗大鼠脊髓损伤的实验研究

研究毫米波对损伤脊髓修复的生物效应。方法采用频率４２．３ＧＨｚ，波长７．１ｍｍ，同功率密度２ｍＷ／ｃｍ＾２，７ｍＷ／ｃｍ＾２，２０ｍＷ／ｃｍ＾２的毫米波治疗大鼠损伤脊髓，３０ｍｉｎ，２次／ｄ＊２０，观察组织学及皮层体感诱发电位、运动诱发电位变化。     

动脉波形分析计算心排出量及临床应用

动脉波形分析技术用于测量心排出量(arterial pressure-based cardiac output,APCO)和每搏输出量变异指数(stroke volume variation,SVV)是一项新的微创血流动力学技术,它能够连续通过对外周动脉的波形特征结合患者的基本信息(年龄、性别、身高、体重等)进行分析测定心排出量(CO),并且不需要通过其他方法来校准.临床上已经显示出可以接受的准确性和良好的即时性和方便性,但也存在一定的局限性,如在一些心脏疾病如主动脉返流、二尖瓣返流或给予α1受体激动药,APCO并不能准确反映心排血量.