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Ulf Kristoffersson Sverre Heim Nils Mandahl Lennart Sundkvist Jan Szelest Inga Hägerstrand 《Clinical genetics》1987,32(3):169-171
A child with multiple anomalies, including growth retardation, a left-sided diaphragmatic hernia with lung hypoplasia, and cerebral malformations is described. Cytogenetic investigation demonstrated a deletion of the distal part of one chromosome 15, del(15)(q24qter), an aberration not previously described. Family studies revealed that the mother had a balanced translocation, t(6;15)(p25;q24). Two of her subsequent pregnancies resulted in abortions after prenatal diagnosis: one fetus was trisomic for 15q24→qter, while the other had monosomy 15q24→qter and a left-sided diaphragmatic hernia similar to the first child. 相似文献
94.
M. E. De Paepe Konstantinos Papadakis Brian D. Johnson Francois I. Luks 《Virchows Archiv : an international journal of pathology》1998,432(1):7-16
Tracheal occlusion in utero has been shown to cause accelerated fetal lung growth and is now being considered as a therapeutic
modality for pulmonary hypoplasia. We report the effects of tracheal ligation on the surfactant-producing type II pneumocyte
population. Three groups of fetal lambs underwent tracheal ligation of 2 weeks’, 4 weeks’ and 6 weeks’ duration, respectively,
and all were sacrificed at 136 days’ gestation (9 days pre-term). Nonoperated twins served as controls. The type II pneumocyte
population was studied morphometrically using a combination of anti-surfactant protein B immunohistochemistry and computer-assisted
stereologic morphometry at light and electron microscopic levels. Single-factor ANOVA was used for statistical analysis. Two
weeks of tracheal ligation resulted in doubling of the total lung volume as a result of airspace distension and, to lesser
extent, growth of the tissue compartment. With increasing duration of tracheal ligation, there was no additional lung growth.
However, more prolonged tracheal occlusion was found to result in significant reduction of the surfactant system, as reflected
in the marked decrease of total pneumocyte type II volume (3.14 cm3, 0.95 cm3, and 0.46 cm3, after 2, 4, and 6 weeks of ligation, compared with 5.96 cm3 for controls) and total pneumocyte type II number (13.9 × 109, 3.8 × 109, and 2.4 × 109, compared with 53.2 × 109 for controls). Ultrastructural analysis of the type II cells in obstructed lungs showed vacuolar degenerative changes that,
after 6 weeks of ligation, were apparently irreversible. In utero tracheal ligation causes fetal lung hyperplasia, but results
in reduction of and injury to the surfactant-producing cell population. Before tracheal occlusion can find widespread clinical
application, its pathophysiology needs to be further elucidated.
Received: 30 April 1997 / Accepted: 10 July 1997 相似文献
95.
P. Vergnes D. Midy J. M. Bondonny H. Cabanie 《Surgical and radiologic anatomy : SRA》1985,7(4):257-265
Summary This paper begins with a review of the embryology of the inguinal region. The authors then point out the special morphological and topographical features of the inguinal canal in male children. These observations were based on the study of 50 inguinal canals from male children. From the anatomical observations described in this study guidelines are proposed for the surgical approach and dissection of the spermatic cord used in the treatment of congenital hernias or abnormal descent of the testis.
Bases anatomiques de la chirurgie inguinale de l'enfant
Résumé Après une étude embryologique de la région inguinale, les auteurs décrivent les particularités morphologiques et topographiques du canal inguinal en croissance de l'enfant de sexe masculin, se basant sur l'étude de 50 cas. De ces notions anatomiques découlent des règles chirurgicales sur la voie d'abord et la dissection du cordon spermatique lors des cures de hernies congénitales ou d'anomalies de migration testiculaire.相似文献
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Respiratory failure from pulmonary hypoplasia continues to be the major cause of death in newborn infants with diaphragmatic hernia. Recent investigations have suggested that postnatally induced pulmonary injury can result from excessive positive or negative intrathoracic pressure and contribute to the respiratory deterioration. Therefore, the method of thoracic drainage on the side of the diaphragmatic hernia is critical in controlling and maintaining normal intrathoracic pressure in both intrathoracic spaces. No chest tube or an ipsilateral chest tube connected to water seal, can result in either excessive negative or positive intrathoracic pressure and, therefore, both methods should be avoided. Recently, we employed a "balanced" intrathoracic drainage system which maintains the ipsilateral intrathoracic pressure within the normal physiologic range of +2 to -8 cm H2O regardless of the degree of pulmonary hypoplasia, presence of an ipsilateral pulmonary air leak, straining by the infant, or mechanical ventilation. This system is simple, requires no suction apparatus, and is easily assembled with equipment readily available within the hospital. This technique has been utilized in 18 newborn infants with diaphragmatic hernia and pulmonary hypoplasia. There have been no complications which specifically could be related to the balanced drainage system. 相似文献
98.
苏宏伟 《中国卫生标准管理》2021,(7):165-168
目的探析腹腔镜与传统手术治疗小儿腹股沟斜疝的临床效果。方法集合本院2016年1月-2019年9月期间接收小儿腹股沟斜疝(年龄<13周岁)234例,以实际治疗术式来分组,传统手术组201例,腹腔镜组33例,对比组行传统手术,腹腔镜组予以腹腔镜手术治疗,对比两组术中失血量、住院时间、初次下床活动时间、术后禁食时长、治疗费用,统计术后并发症并行组间对比。结果此次研究显示腹腔镜组术中失血量更少、术后禁食时长及初次下床活动时间更短(P<0.05),住院时间及、治疗费用组间对照中,腹腔镜组住院时间显著更短但治疗费用显著更高(P<0.05),术后并发症统计显示,腹腔镜组并发症发生率显著更低(P<0.05)。结论在小儿腹股沟斜疝治疗中腹腔镜手术虽费用较高,但患儿术后并发症更少,恢复更快,可优先选用。 相似文献
99.
Christos Doudakmanis Christina Kolla Konstantinos Bouliaris Matthaios Efthimiou Georgios D Koukoulis 《World Journal of Methodology》2022,12(4):193-199
Inguinal hernias are amongst the most common conditions requiring general surgical intervention. For decades, the preferred approach was the open repair. As laparoscopy became more popular and available and more surgeons became familiarized with this modality, laparoscopic inguinal hernia repair became an alternative. The aim of this study is to assess the effectiveness of laparoscopic inguinal repair, with a focus on bilateral inguinal hernias. Initial reports have shown promising clinical outcomes compared to those of conventional repair of bilateral hernias. However, there are only a few studies concerning laparoscopic repair of bilateral hernias. It is yet to be proven that laparoscopy is the “gold standard” in the treatment of bilateral inguinal hernias. So far, the choice of an inguinal hernia repair technique has been up to each surgeon, depending on their expertise and available resources after taking into consideration each patient’s needs. 相似文献
100.
目的:探讨腰椎间盘突出症合并神经根管狭窄的临床诊断和手术治疗。方法:对1996-1999年间,因腰椎间盘突出症合并神经根管狭窄38例行手术治疗,术中均行神经根管探查并彻底松解受压神经根。结果:术后随访38例,优20例,良15例,一般2例,差1例,优良率92.11%。结论:神经根管扩大和神经根探查彻底减压是手术成功的关键。 相似文献