Identification of histiocytic reticulum cells by the immunohistochemical demonstration of factor XIII (F-XIIIa) in human lymph nodes

Morphologically and enzyme histochemically distinguishable tissue macrophages and stromal cells of human reactive lymph nodes were characterized by the cytoplasmic presence of the subunit A of factor XIII and by the expression of surface antigenic determinants reacting with monoclonal antibodies directed against monocyte/macrophage populations (Mo 1, Leu M3) and HLA-DR antigens. The distribution of F-XIIIa positive cells was studied on formaldehyde-fixed paraffin-embedded sections with immunoperoxidase techniques. established on cryostat section with double immunofluorescence. Alpha-Naphthyl acetate esterase (ANAE) reaction was The immunophenotype was established on cryostat sections with double immunofluorescence. Alpha-Naphthyl acetate esterase (ANAE) reaction was carried out on these cryostat sections to identify tissue macrophages. The antibody against F-XIIIa detected histiocytes in both intra- and extra-sinusoidal locations which were ANAE+, Mo 1+, Leu M3+ and HLA-DR-. F-XIIIa was also present in fibroblast-like mesenchymal cells with the following phenotypic characteristics: ANAE-, Mo 1+, Leu M3+ and HLA-DR+. The anti F-XIIIa antibody did not stain lymphoid cells, granulocytes, epithelial cells, endothelial cells and mast cells. The immunohistochemical detection of F-XIIIa works on formaldehyde-fixed paraffin-embedded sections. The most promising application seems to be the identification of histiocytes in lymphoid and histiocytic proliferations.     

Malignant epithelioid haemangioendothelioma of the liver: a clinicopathological and histochemical study of 12 cases

We describe the clinicopathological findings in 12 cases of hepatic epithelioid haemangioendothelioma in order to identify diagnostic and prognostic features of this unusual vascular neoplasm. Three main tumour patterns were observed histologically: (1) a peripheral pattern with neoplastic cells scattered between fairly normal liver cell plates; (2) a cellular pattern showing a confusing admixture of pleomorphic tumour cells and atrophied hepatocytes set in a small amount of fibrous stroma; and (3) a scarred pattern with sparse tumour cells in a dense fibrous matrix. There were two types of vascular invasion: tuft-like intravascular proliferations of epithelioid cells and fibro-thrombotic venous occlusions. Awareness of these different aspects is important, as they are variably sampled by biopsy needles. The clinical course in this series was less favourable than that previously reported. Eight patients have died, in six instances of liver failure within 4-41 months of diagnosis. Extensive involvement of both lobes of the liver heralds imminent hepatic failure. The slow growth of metastases may justify liver transplantation in order to prolong life.     

Autonomic Correlates of Sensation Seeking and Monoamine Oxidase Activity: Using Confirmatory Factor Analysis on Psychophysiological Data

A negative relationship between platelet monoamine oxidase (MAO) activity and Sensation Seeking (SS) has been reported in several studies. This study evaluates the possible contribution of autonomic nervous system (ANS) activity to this relationship. Additionally, confirmatory factor analysis was used to create models of ANS concepts from a larger number of psychophysiological variables. Skin conductance (SC) and heart rate (HR) were recorded from 46 men and 49 women during a two-session protocol that included rest periods, a balloon stress, a series of tones, and two tasks: two-flash threshold and tachistoscopic recognition. Results showed that the best-fitting models for both rest and task periods included concepts of SC base levels (“arousal”), SC lability, and HR, and were quite similar for men and women. MAO activity correlated positively with SC concepts, most strongly for women. Women showed negative relationships between sensation seeking and both SC arousal and HR concepts. In contrast, men showed evidence of positive relationships between SC concepts and an active life style. The sex differences and response specificity in these relationships make it unlikely that ANS activity mediates the negative MAO-SS relationship.     

A patient with an interstitial deletion of the short arm of chromosome 6

The clinical history and subsequent progress of a child with an interstitial deletion in the short arm of chromosome 6 is described. This abnormality coupled with a reduced Hageman factor (Factor XII) led to an earlier publication which suggested that this gene was localized to the breakpoint region involved. A review of similar phenotypes from the literature is presented.     

胰岛素样生长因子(IGF)与子宫内膜异位症关系的研究进展

本文对IGF家族的组成、结构、在多种肿瘤中的作用机制及其在内异症中的研究进展作一综述,旨在为内异症的诊治提供新的依据。其中研究较明确的是IGF-I和IGFBP-3。IGF-I促进甾体激素的生成、促进细胞增殖、抑制细胞凋亡,与多种肿瘤的发生有关。IGF-I促进异位子宫内膜生长,与内异症形成有关。IGFBP-3作用与IGF-I相反,可能是通过与IGF-I的结合而实现。     

西藏6个高海拔县藏族人群骨质疏松患病现状及其影响因素研究

目的 了解西藏地区6个高海拔县藏族成年人骨质疏松的患病现状及其影响因素。方法 采用多阶段分层随机抽样,从西藏地区6个高海拔县随机抽取1 309名藏族居民作为研究对象,采用χ2检验和logistic回归方法分析该地区骨质疏松检出率情况及影响因素。结果 西藏地区6个高海拔县成年女性骨质疏松的检出率为3.8％,男性为3.0％;60岁及以上女性骨质疏松的检出率为16.7％,男性为12.8％。Logistic回归分析结果显示:在女性群体中,年龄、从事农牧活动、BMI、绝经与骨质疏松的发生有关。在男性群体中,年龄与骨质疏松的发生有关。结论 西藏地区6个高海拔县60岁及以上男性和女性的骨质疏松的检出率偏低。增龄是该地区藏族成年女性、男性骨质疏松发生的独立危险因素。绝经、BMI偏低是该地区成年女性骨质疏松发生的独立危险因素。从事农牧活动是该地区成年女性骨质疏松发生的保护因素。     

流动人口住院费医保报销现状及影响因素分析

目的 了解流动人口住院费医保报销现状及其影响因素,为减轻流动人口医疗经济负担提供参考。方法 利用2018年全国流动人口卫生计生动态监测数据,运用χ2检验和logistic回归分析流动人口住院费医保报销现状及其影响因素。结果 3 364名调查对象中,2 346名（69.7%）流动人口报销住院费,其中有18人重复报销,报销总人次为2 364次。2 346名报销者中,66.5%在流入地报销住院费。从报销总人次来看,不同参保类型的流动人口住院费报销情况不同,参加城镇职工医疗保险的报销率最高,为82.2%;而报销地点上,参加城乡居民医保、城镇居民医保、城镇职工医保的选择在流入地报销分别占76.1%、79.9%和89.8%。多因素结果显示,年龄为35～44岁（OR = 1.474,95%CI:1.083～2.007）、45～54岁（OR = 2.223,95%CI:1.587～3.115）、55～64岁（OR = 2.320,95%CI:1.562～3.446）、65岁及以上（OR = 4.179,95%CI:2.576～6.778）,受教育层次为高中（OR = 1.397,95%CI:1.077～1.811）、大专（OR = 1.887,95%CI:1.390～2.562）、本科及以上（OR = 2.427, 95%CI:1.660～3.548）,流动时间6～10年（OR = 1.282,95%CI:1.058～1.554）、10年以上（OR = 1.264,95%CI:1.018～1.570）,省内流动（OR = 1.483,95%CI:1.234～1.781）、市内流动（OR = 1.883,95%CI:1.502～2.360）,异地养老（OR = 2.305,95%CI:1.052～5.052）,流入西部（OR = 1.283,95%CI:1.061～1.551）是流动人口报销住院费的保护因素;从事商业及服务业 （OR = 0.429,95%CI:0.301～0.611）、生产及运输业（OR = 0.645,95%CI:0.431～0.966）、其他（OR = 0.421,95%CI:0.295～0.600）是流动人口报销住院费的危险因素。结论 流动人口住院费医保报销仍有较大的提升空间。应提高医保区域统筹层次,优化医保报销流程,加强对流动人口医保政策宣传,做好流动人口医保报销工作。     

宁夏川区和山区妇女抑郁情绪现状及影响因素分析

目的了解宁夏川区和山区妇女抑郁情绪现状及影响因素的差异,为制定基于地区的妇女抑郁防控措施提供依据。方法2020年7—8月以方便抽样法选取调查对象,采用自制一般人口学问卷、患者健康问卷(PHQ-9)及精神卫生与心理保健知识问卷对1816名妇女进行面对面问卷调查。结果川区和山区妇女抑郁总分分别为(5.04±3.55)分和(4.20±3.49)分,情感维度得分分别为(3.11±2.33)分和(2.69±2.28)分,身体症状维度得分分别为(1.93±1.60)分和(1.51±1.49)分,差异均有统计学意义(t=4.892,3.766,5.510,均P<0.05)。多元线性回归分析结果显示:影响川区妇女抑郁得分的因素包括年龄、文化程度、家庭年收入、精神卫生与心理保健知识水平(均P<0.05);影响山区妇女抑郁得分的因素包括户籍、年龄、职业及家庭常住人口数(均P<0.05)。结论宁夏川区妇女抑郁情绪比山区妇女更突出,川区和山区妇女抑郁情绪的影响因素有一定差异。今后应基于川区和山区社会环境的差异评估妇女抑郁情绪的流行状况,开展监测与差异化干预。     

粤西某市城区寄宿学校中学生不良饮食行为现状与影响因素分析

目的 了解粤西某市城区寄宿的中学生饮食行为现状与影响因素,为探索干预方法提供依据。方法 自编调查问卷,2021年10月对某城区全部有食宿条件的10所中学,用分层抽样法现场调查547名初一至高二学生,对5种饮食行为与相关因素进行描述分析和logistic回归分析。结果 饮食的5种行为不良率从高到低依次为:吃外卖(49.0%)、不吃早餐(31.7%)、喝奶茶(24.3%)、吃夜宵(11.8%)、零食代餐(1.3%);“学生可支配费用少于100元/星期”“学校饭堂饮食口味评价——不满意”两个因素均能促成5种不良饮食行为发生(P<0.05),“饮食重要性感知意识——不重要”因素对“喝奶茶”“吃夜宵”行为影响强度最大(OR=4.386,P=0.019;OR=5.780,P=0.006);女生能促成“吃外卖”(OR=1.586,P=0.015)和“喝奶茶”(OR=1.770,P=0.010),“每星期可支配消费超过200元以上”能促成“吃外卖”和“吃夜宵”(OR=2.346,P=0.001;OR=2.585,P=0.009)。结论 城区寄宿学校中学生不良饮食行为问题突出,不满学校饭堂饮食口味对促发不良饮食行为影响最广,“认为饮食不重要”是促发不良行为产生的最强因素,亟须加强寄宿中学饮食支持条件的管理,加强学生饮食健康教育,控制当前城市寄宿学校中学的学生不健康饮食行为。