Assessment of inflammatory bowel disease educational videos for increasing patient engagement and family and friends’ levels of understanding

ObjectiveWe developed five educational videos through a user-centered approach for patients with inflammatory bowel diseases (IBD) and their families and friends. Here, we assessed if IBD patient activation and family and friends’ abilities to understand IBD patients’ thoughts, feelings, and behaviors (i.e., perspective taking) changed after watching the videos.MethodsThrough a pre-post survey, we assessed patient activation and perspective taking levels in people with a self-reported IBD diagnosis and their family and friends, respectively, before and after watching one of the videos.ResultsAmong 767 participants with IBD, patient activation scores increased significantly after watching each video. In regression analyses, patient activation levels were less likely to increase in biologic-naïve participants after viewing the coping video. Among 232 people who knew someone with IBD, perspective taking scores increased significantly in 8/9 domains, which was more likely to occur among women.ConclusionsEducational videos developed through a user-centered approach were associated with higher self-reported IBD patient activation scores and perspective taking levels among family and friends.Practice implicationsThese videos, which are now widely disseminated on social media, serve as a model for how to create educational materials for improving patient activation and empathy in the social media era.     

炎症性肠病患者病耻感体验的质性研究

目的探索炎症性肠病患者的病耻感体验,揭示患者的病耻感经历及其影响因素,为医护人员开展针对性心理护理提供理论依据。方法采用目的抽样法,选取2017年3月—2019年7月在浙江省3家三级甲等医院消化内科门诊就诊和病房住院的16例炎症性肠病患者为研究对象,采用描述性质性研究的方法,对患者进行面对面半结构式访谈,运用传统内容分析法分析资料。结果分析得出炎症性肠病患者病耻感体验的4个主题,分别为感知病耻感、实际病耻感、内化病耻感及影响病耻感产生的因素。结论受疾病、治疗、自身心理状态及社会风俗文化等因素的影响,多数炎症性肠病患者确诊疾病后存在病耻感体验,但其具体表现形式及程度存在差异。医护人员应在了解患者病耻感体验的基础上,提供个体化的照护,并给予可行的病耻感应对策略。     

Poor efficacy of TNF inhibitors in non-radiographic axial spondyloarthritis in the absence of objective signs: A bicentric retrospective study

Objective

To compare BASDAI 50 response rate to TNFi in axial spondyloarthritis (axSpA) depending on the presence or not of objective signs of axSpA and to look for predictive factors of TNFi efficacy.

眼眶炎性假瘤超声显像及其病理基础初探

本文初步探讨了眼眶炎性假瘤的超声显像及其病理基础.结果:眼眶炎性假瘤的声像图表现无特异性,易与眼眶内真性肿瘤相混淆,但其声像图结合临床表现有助于此病的诊断.眼眶内炎性假瘤不同的声像图表现取决于其不同的病理组织结构含量.超声显像是诊断眼眶炎性假瘤的首选方法之一.     

巨噬细胞中钙调蛋白2的缺失可缓解小鼠炎症性关节炎

目的研究探讨抑制巨噬细胞中钙调蛋白2的表达治疗炎症性关节炎的作用和相关机制。方法取野生型小鼠(wild type,WT)和钙调蛋白2敲除(knock out, KO)小鼠构建胶原诱导炎症性关节炎模型(collagen induced arthritis,CIA),检测炎症相关因子TNF-α、IL-1β、IL-6和TGF-β的mRNA及蛋白表达变化、小鼠足趾肿胀容积变化以及炎症组织细胞大小和增殖变化。进一步在293T细胞中检测钙调蛋白2和CCL3(macrophage inflammatory protein 1-α, MIP-1α)的结合情况。在骨髓单核巨噬细胞(bone marrow macrophages,BMMs)细胞中转染钙调蛋白2过表达和抑制慢病毒,检测钙调蛋白2潜在下游CCL3的表达。最后,使用抑制钙调蛋白2的慢病毒进行炎症性关节炎小鼠的治疗作用探索,进行上述病理性检测。结果荧光定量PCR和免疫印迹实验显示,钙调蛋白2 KO小鼠关节炎组织炎症因子分泌明显降低;足趾肿胀容积明显减小;炎症组织细胞明显变大,细胞增殖明显增多。荧光素酶实验和染色质免疫共沉淀实验结果显示,钙调蛋白2...     

The evolving landscape of N6-methyladenosine modification in the tumor microenvironment

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Targeting the tissue-complosome for curbing inflammatory disease

Hyperactivated local tissue is a cardinal feature of immune-mediated inflammatory diseases of various organs such as the joints, the gut, the skin, or the lungs. Tissue-resident structural and stromal cells, which get primed during repeated or long-lasting bouts of inflammation form the basis of this sensitization of the tissue. During priming, cells change their metabolism to make them fit for the heightened energy demands that occur during persistent inflammation. Epigenetic changes and, curiously, an activation of intracellularly expressed parts of the complement system drive this metabolic invigoration and enable tissue-resident cells and infiltrating immune cells to employ an arsenal of inflammatory functions, including activation of inflammasomes. Here we provide a current overview on complement activation and inflammatory transformation in tissue-occupying cells, focusing on fibroblasts during arthritis, and illustrate ways how therapeutics directed at complement C3 could potentially target the complosome to unprime cells in the tissue and induce long-lasting abatement of inflammation.     

过氧化物酶体增殖剂活化受体与心肌重塑

过氧化物酶体增殖剂活化受体是一类核转录因子 ,具有多种有益的生理作用 :参与心脏能量代谢 ,增加胰岛素敏感性 ,阻断过度激活的肾素 血管紧张素系统和胰岛素抵抗形成的恶性循环 ,抑制炎症反应 ,改善心功能 ,提高血管顺应性、降低后负荷 ,对抗心肌重塑。缺血 /再灌注时过氧化物酶体增殖剂活化受体激动剂抑制心肌组织炎症细胞浸润 ,减轻心肌缺血 /再灌注损伤而保护心脏。     

Acute dermatomyositis associated with generalized subcutaneous edema

Generalized subcutaneous edema is an uncommon manifestation of inflammatory myopathy. We report a 48-year-old female patient who presented with severe generalized edema, an erythematous skin rash, dysphagia and proximal muscle weakness. She was diagnosed with dermatomyositis from the clinical signs, increased muscle enzymes, electromyographic findings and a muscle biopsy. Magnetic resonance imaging revealed increased signal intensity in the muscular and subcutaneous layers. The conditions causing generalized edema were excluded. It was concluded that the generalized edema was secondary to dermatomyositis. Aggressive treatments with high-dose glucocorticoids and immunosuppressive agents were used to control the severe subcutaneous edema.