Transepithelial photorefractive keratectomy (tPRK) promotes faster re-epithelialization which in turn can reduce the risk of infectious keratitis in the postoperative period. We present a case of a 22-year-old man with infectious keratitis in his left eye 8 days after an uneventful bilateral tPRK. A 2 mm × 5 mm anterior stromal area of corneal infiltration with a same sized overlying epithelial defect was noted at the time of presentation. His uncorrected distance visual acuity was 20/63 in his left eye. Corneal scrapings showed Bordetella bronchiseptica. The infection responded to intensive treatment with topical levofloxacin 0.5% eye drops. The final visual acuity was 20/20 in the left eye. 相似文献
This was a novel, prospective and interventional animal study designed to develop and evaluate a new infliction device for the experimental burn model.Four paired sets of contact burns measuring 36 mm diameter were inflicted on the dorsum of an anesthetized pig using a stainless steel round bar heated up to 80–110 °C. The bar was applied using a push–pull force gauge designed to control 1 kgf mechanical force applied to the skin for a period of 20 s. The left dorsum was used for macroscopic observation and the right dorsum was used for histopathological evaluation. A total of eight burns were covered with moist saline dressings and given daily treatments of xylocaine (lidocaine HCl) gel. This procedure was followed for a period of 24 days. Full-thickness biopsies were obtained for histologic analysis to determine the extent of injury.Statistical analysis showed a high correlation between the exposure temperature and histopathological assessment. The results found the depth of injury to the collagen (Seg1) correlated with the temperature (Ti) at which the burns was inflicted, Seg1 = 0.038Ti − 2.57 (r = 0.973, P < 0.05). Also, the histological studies show a high correlation between the depth of collagen denaturation in wounds and the exposure temperature, Seg1 = 0.0268Ti − 0.165 (r = 0.991, P < 0.05). This model is useful to assess more closely the therapeutic agents used for wound healing in experimental burn wounds. 相似文献
This article outlines the physical principles underlying peripheral nerve stimulation and depth of anaesthesia monitoring in relation to anaesthesia. The patterns of nerve stimulation most commonly used in clinical practice are described including train-of-four, double burst stimulation and tetanic stimulation, as well as methods used to measure motor response. The key technologies currently used to monitor level of consciousness during anaesthesia are also described, namely methods based on electroencephalography and stimulus evoked potentials, including limitations of their use. Published clinical guidelines on the use of both nerve stimulators and level of consciousness monitors are also discussed. 相似文献