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951.
甲型流流感病毒鼠肺适庆型75-39株治疗S37腹水型荷瘤小鼠,存活率达93.3%。体外实验观察流感病毒感染S37肿瘤细胞,到3天时S37细胞经胎盘蓝染色,100%的S37细胞死亡,而对照组肿瘤细胞染色率只有10%左右。 相似文献
952.
VE缺乏组、1/3需要量组、需要量组、3倍需要量组、20倍需要量组的初断奶小鼠喂养8周后观察T淋巴细胞转化及M中诱导IL-1反应。结果表明,VE增强半合适、合适剂量ConA诱导的胸腺、脾脏T淋巴细胞转化,且半合适剂量诱导的反应高于合适剂量,VE增强合适剂量PHA诱导的脾T细胞反应,但不影响其诱导胸腺T细胞反应。VE还提高MΦ诱导IL-1生成。上述实验以缺乏组反应最弱,3倍量组反应最强,而20倍量组反有下降趋势。 相似文献
953.
以分离的细胞膜为受体制剂,对大鼠卵巢及睾丸人绒毛膜促性腺激素(HCG)受体进行比较研究,发现二者的受体结合特性有一定差异;同时将大鼠寒丸膜及睾丸匀浆作对比,友现睾丸膜制剂较睾丸匀浆更能准确地体现睾丸HCG受体的真正特性。 相似文献
954.
刘国普 《广州中医药大学学报》1990,(1)
本文通过对364例溃疡病患者的住院系统治疗观察,认为溃疡病的主要病机是脾虚。活动期与肝郁及胃热有关;迁延难愈多因胃络瘀阻;胃酸增高为本病的普遍现象。故本病治疗应以健脾胃,佐以疏肝活血、清热、制酸之法。方药如用四君子汤加黄芪、白芍、郁金、三棱、蒲公英、乌贼骨等为基础方加减;对有胆汁返流者,则应配以疏肝清胆,降逆通腑之品。临床近期治愈率可达82.4%。 相似文献
955.
We describe the pathological findings in two fatal cases of neonatal infection with herpes simplex virus. One had an encephalitis caused by herpes simplex virus type 2 (HSV-2); the other had a disseminated infection with herpes simplex virus type 1 (HSV-1). Confirmation of the diagnosis was obtained by use of the polymerase chain reaction to amplify viral DNA from paraffin sections of autopsy tissues. By using primers which amplify fragments of the HSV-1 thymidine kinase gene and HSV-2 glycoprotein gene respectively it was possible to discriminate between infection with HSV-1 and HSV-2. In contrast, immunohistochemistry and in situ hybridization using commercially available reagents did not distinguish between HSV-1 and HSV-2 infection. However, immunohistochemistry and in situ hybridization are probably more reliable than the polymerase chain reaction for assessment of the distribution of virus in different tissues. 相似文献
956.
957.
Leon A. Weisberg Jack Greenberg Antonio Stazio 《Computerized medical imaging and graphics》1988,12(6):379-383
The clinical and computerized tomographic (CT) findings in 10 patients with cerebral toxoplasmosis are reviewed. All patients with cerebral toxoplasmosis were homosexuals and/or intravenous drug users, and all patients had other manifestations of AIDS. Two presented with focal seizures, 4 presented with focal neurological deficit which progressively worsened, and 4 had evidence of diffuse neurological dysfunction (altered consciousness, generalized seizures). CT showed a single lesion in 3 patients and multiple lesions in 7 patients. Two patients had hypodense nonenhancing lesions(s). Eight patients had hypodense lesions with peripheral or nodular enhancement. The lesions were more commonly located in the cerebral hemispheres and subcortical gray matter nuclear masses (thalamus, basal ganglia). The finding of a hypodense lesion with a central slightly hyperdense noncalcified region that showed dense nodular homogeneous enhancement was quite characteristic of cerebral toxoplasmosis, but this pattern may also be seen in other neurological conditions including brain lymphomas. 相似文献
958.
Nerve biopsy findings in Niemann-Pick type II (NPC) 总被引:1,自引:0,他引:1
A. F. Hahn J. J. Gilbert C. Kwarciak J. Gillett C. F. Bolton C. A. Rupar J. W. Callahan 《Acta neuropathologica》1994,87(2):149-154
The severe infantile form of Niemann-Pick disease type II was diagnosed in a 4-year-old girl and confirmed by demonstrating in cultured skin fibroblasts a deficiency of low-density lipoprotein-stimulated cholesterol ester synthesis of < 5% of normal. Electrodiagnostic studies revealed changes of a predominantly demyelinating motor and sensory polyneuropathy. Light microscope and ultrastructural examination of a peroneal nerve biopsy showed unique changes. Compacted myelin sheaths were disproportionately thin with marked globular irregularities in single teased nerve fibres and evidence of chronic demyelination. The majority of axons were preserved but axonal spheroids and cytoskeletal abnormalities akin to neuroaxonal dystrophy were noted. Membrane-bound multilobulated lysosomal inclusions of floccular and electron-dense material were present in Schwann cells (SC), endoneurial fibroblasts, macrophages, pericytes and endothelial cells. SC of myelinated fibres were stuffed with whorls of concentric osmiophilic membranous profiles and electron-lucent material. The findings are diagnostic and differ from those of classical Niemann-Pick disease. 相似文献
959.
39例慢性肝炎患者,其中乙型肝炎12例,丙型肝炎27例,接受人α_1型基因工程干扰素治疗(rHIFNα_1)。10例丙型肝炎病人rHIFNα_1每日肌注1×10 ̄6U,连用90天,17例丙型肝炎病人和乙型肝炎rHIFNα_1每日肌注3×10 ̄6U,连用90天。治疗后乙型肝炎组HBeAg和HBVDNA的阴转率均为41.67%;丙型肝炎用1×10 ̄6U/d和3×10 ̄6U/d组HCVRNA阴转率分别为50%和64.7%,两个剂量组阴转率比较差异无显著性(P>0.05),治疗期间不良反应发生率较低,远期疗效尚待观察。 相似文献
960.
Jos A. Brieva Ernesto Roldn Carmen Rodríguez Gloria Navas 《European journal of immunology》1994,24(2):362-366
Human B cells capable of spontaneous IgG secretion are commonly found in circulation and in lymphoid tissues such as tonsil and bone marrow (BM). The present study compares the mechanisms that regulate tonsil, blood and BM B cells capable of spontaneous IgG secretion. The BM cell subset produced IgG during a markedly longer period of time (14 days) than did tonsil and blood cell subsets (2–3 days). Blood and BM, but not tonsil, B cell IgG secretion depended on the presence of adherent cells, as demonstrated by adherent cell depletion and re-addition experiments. Stromal BM cells supported linear IgG secretion by non-adherent BM cells for 2 weeks, but were unable to prolong the short-term IgG secretion by tonsil and blood cells. Different factors induced IgG secretion in each of the three B cell populations as optimal IgG secretion by tonsil, blood or BM cell subsets required either tumor necrosis factor-α, interleukin-6 or fibronectin + interleukin-6, respectively. Finally, these populations also showed differences in the expression of adhesion molecules; the tonsilar cell subset was PNA+/? CD44+ CD49d+ CD49e? Leu-8+/?, the blood cell subset was PNA? CD44+/? CD49d+ CD49e? Leu-8+ and the BM cell subset was PNA? CD44+/? CD49d+ CD49e? Leu-8?. These results suggest that the mechanisms controlling the final differentiation and the expression of adhesion molecules in these B lymphocytes exhibit territorial specificity. 相似文献