全文获取类型
收费全文 | 299708篇 |
免费 | 26571篇 |
国内免费 | 11258篇 |
专业分类
耳鼻咽喉 | 1872篇 |
儿科学 | 7399篇 |
妇产科学 | 4312篇 |
基础医学 | 58071篇 |
口腔科学 | 5267篇 |
临床医学 | 21281篇 |
内科学 | 55163篇 |
皮肤病学 | 4992篇 |
神经病学 | 20272篇 |
特种医学 | 5487篇 |
外国民族医学 | 64篇 |
外科学 | 19921篇 |
综合类 | 38420篇 |
现状与发展 | 51篇 |
一般理论 | 1篇 |
预防医学 | 21450篇 |
眼科学 | 3349篇 |
药学 | 34047篇 |
66篇 | |
中国医学 | 10500篇 |
肿瘤学 | 25552篇 |
出版年
2024年 | 752篇 |
2023年 | 4541篇 |
2022年 | 9564篇 |
2021年 | 12181篇 |
2020年 | 10499篇 |
2019年 | 10957篇 |
2018年 | 10442篇 |
2017年 | 10594篇 |
2016年 | 10803篇 |
2015年 | 12450篇 |
2014年 | 18358篇 |
2013年 | 19944篇 |
2012年 | 18278篇 |
2011年 | 21270篇 |
2010年 | 17549篇 |
2009年 | 16879篇 |
2008年 | 16199篇 |
2007年 | 14983篇 |
2006年 | 13432篇 |
2005年 | 11517篇 |
2004年 | 9976篇 |
2003年 | 8542篇 |
2002年 | 6726篇 |
2001年 | 5980篇 |
2000年 | 4974篇 |
1999年 | 4473篇 |
1998年 | 3940篇 |
1997年 | 3665篇 |
1996年 | 3232篇 |
1995年 | 2893篇 |
1994年 | 2610篇 |
1993年 | 2220篇 |
1992年 | 1870篇 |
1991年 | 1635篇 |
1990年 | 1404篇 |
1989年 | 1199篇 |
1988年 | 1086篇 |
1987年 | 882篇 |
1986年 | 820篇 |
1985年 | 1408篇 |
1984年 | 1295篇 |
1983年 | 894篇 |
1982年 | 943篇 |
1981年 | 772篇 |
1980年 | 636篇 |
1979年 | 557篇 |
1978年 | 438篇 |
1977年 | 345篇 |
1976年 | 315篇 |
1975年 | 186篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
13.
Behzad Emadi Mojtaba Ghahraman Rezaieh Mansour Sedighi 《Transfusion and apheresis science》2021,60(3):103132
Transfusion transmissible infections (TTIs) have been a public health challenge for the accessibility, quality and safety of blood transfusion. The present study aimed to consider the prevalence and the trends of hepatitis B virus (HBV), hepatitis C virus (HCV), Human T-cell leukemia virus type 1 (HTLV-1), human immunodeficiency virus (HIV) and syphilis across the ten years among retrospective blood donors. A retrospective investigation of blood donors’ data covering the period from 22 May 2009 to 22 May 2019 was done. Data was accumulated and analyzed from Blood Transfusion Center records, pertaining to all donors who were screened for various TTIs using respective immunological techniques. Out of the 682,171 screened donors in the 2009–2019 study period, 2470 (0.36 %) were infected with at least one infectious agent. The overall prevalence of HBV, HCV, HTLV-1, HIV and syphilis were 1700 (0.25 %), 184 (0.027 %), 335 (0.05 %), 4 (0.0.05 %) and 247 (0.036 %), respectively. The study showed male dominated donor pool (96.79 %) with higher prevalence (0.34 %) of TTIs compared to female donors (0.02 %) with 3.21 % population. Despite the low prevalence of TTIs in our study, HBV, HCV, syphilis and HIV have remained a big threat to safe blood transfusion in Iran. Strict adherence to selection criteria, algorithm of donor screening, use of highly sensitive and specific methods for detection of TTIs, regular consultation and health education programs, prevention and sanitization strategies to reduce the risk of TTIs are recommended to reduce the risk of TTIs and ensure the safety of blood transfusion for recipient. 相似文献
14.
《Cancer cell》2021,39(9):1214-1226.e10
- Download : Download high-res image (204KB)
- Download : Download full-size image
15.
16.
《Digestive and liver disease》2022,54(11):1486-1493
BackgroundCold snare polypectomy (CSP) is a promising technique for the removal of sessile serrated polyps (SSPs) ≥ 10 mm. However, the efficacy and safety of this technique remain undetermined.AimsWe aimed to comprehensively evaluate the efficacy and safety of CSP for SSPs ≥ 10 mm.MethodsPubMed, EMBASE, Web of Science and Cochrane Library were searched up to January 2021.ResultsA total of 10 studies consisting of 1727 SSPs (range, 10–40 mm) from 1021 patients were included. The overall rates of technical success, adverse events (AEs) and residual SSPs were 100%, 0.7% and 2.9%, respectively. Subgroup analysis showed that the rates of technical success and AEs were comparable between CSP and cold endoscopic mucosal resection (EMR) (99.9% vs. 100% and 1.3% vs. 0.5%, respectively), between the proximal and distal colon (100% vs. 99.9% and 0.3% vs. 0, respectively), and between polyps of 10–19 mm and ≥20 mm (99.8% vs. 100% and 0.9% vs. 0, respectively). However, subgroup analysis showed that the rate of residual SSPs was slightly lower in CSP compared with cold EMR (1.3% vs. 3.9%), as well as in polyps of 10–19 mm compared with those ≥20 mm (3.1% vs. 4.7%).ConclusionCSP was an effective and safe technique for removing SSPs ≥ 10 mm. 相似文献
17.
Major depressive disorder and other neuropsychiatric disorders are often managed with long-term use of antidepressant medication. Fluoxetine, an SSRI antidepressant, is widely used as a first-line treatment for neuropsychiatric disorders. However, fluoxetine has also been shown to increase the risk of metabolic diseases such as non-alcoholic fatty liver disease. Fluoxetine has been shown to increase hepatic lipid accumulation in vivo and in vitro. In addition, fluoxetine has been shown to alter the production of prostaglandins which have also been implicated in the development of non-alcoholic fatty liver disease. The goal of this study was to assess the effect of fluoxetine exposure on the prostaglandin biosynthetic pathway and lipid accumulation in a hepatic cell line (H4-II-E-C3 cells). Fluoxetine treatment increased mRNA expression of prostaglandin biosynthetic enzymes (Ptgs1, Ptgs2, and Ptgds), PPAR gamma (Pparg), and PPAR gamma downstream targets involved in fatty acid uptake (Cd36, Fatp2, and Fatp5) as well as production of 15-deoxy-Δ12,14PGJ2 a PPAR gamma ligand. The effects of fluoxetine to induce lipid accumulation were attenuated with a PTGS1 specific inhibitor (SC-560), whereas inhibition of PTGS2 had no effect. Moreover, SC-560 attenuated 15-deoxy-Δ12,14PGJ2 production and expression of PPAR gamma downstream target genes. Taken together these results suggest that fluoxetine-induced lipid abnormalities appear to be mediated via PTGS1 and its downstream product 15d-PGJ2 and suggest a novel therapeutic target to prevent some of the adverse effects of fluoxetine treatment. 相似文献
18.
《Vaccine》2022,40(32):4296-4300
Advanced computational methodologies suggested SARS-CoV-2, nonstructural proteins ORF1AB, ORF3a, as the source of immunodominant peptides for T cell presentation. T cell immunity is long-lasting and compatible with COVID-19 pathology. Based on the supporting clinical data, nonstructural SARS-CoV-2 protein vaccines could provide global immunity against COVID-19. 相似文献
19.
20.
[摘要]?目的?结合环介导等温扩增技术(loop-mediated isothermal amplification, LAMP)和微流控芯片技术,建立一种适合现场快速检测登革病毒的方法。方法?利用RT-LAMP,针对登革病毒基因组中3’非编码区中特异性序列进行扩增,建立基于微流控芯片技术的LAMP检测方法,优化检测体系,并对该方法的灵敏性和特异性进行评估。结果?基于LAMP 和微流控芯片技术的登革病毒检测方法,通过对病毒模板进行扩增,发现与其他病毒无交叉反应,特异性良好;同时,结果显示该方法对登革病毒检测灵敏性可达61.2 pg/μl,与实时荧光定量PCR仪所达到的检测灵敏性一致。结论?基于LAMP和微流控芯片技术的登革病毒检测方法具有操作简单、快速、对设备要求低等优势,并且灵敏性、特异性均较好,是一种便于开展现场快速检测的方法。 相似文献